Guanhua Li

Impact of a high-profile sudden cardiac death on emergency department utilization: a multi-campus interrupted time series and exploratory phenotyping study

Chenxi Wang, Han Cai, Xiujuan Hu, Jiayu Liu et autres

BACKGROUND: High-profile public health events can be temporally associated with significant shifts in healthcare-seeking behavior. We aimed to quantify the surge in emergency department (ED) volume and characterize the demographic shifts following a high-profile sudden cardiac death (SCD) event of a nationally …

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Retraction: The effects of the M2a macrophage-induced axonal regeneration of neurons by arginase 1

Jieyuan Zhang, Yue Li, Zhaoxia Duan, Jianyi Kang et autres

This article is being retracted from Bioscience Reports at the request of the Editor-in-Chief and the Editorial Board.This follows the receipt of a notification from a reader, alerting the Editorial Board to an instance of high similarity in Figure 1A between the …

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An early prediction model of septic shock in patients with Escherichia coli bloodstream infection based on machine learning

Xinran Qiu, Yi Wu, Wenqi Ouyang, Jin Zhou et autres

Escherichia coli bloodstream infection ( E. coli BSI) is a global clinical challenge with markedly higher mortality once it progresses to septic shock. Current tools are impractical in primary care, creating an urgent clinical need for accessible, laboratory-based early prediction tools. Thus, …

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Multimodal evaluation of 525 nm laser-induced retinal injury in rabbits: structural, functional and cytokine analyses

Ling Guo, 陈魁君, Guanhua Li, Jian Zeng et autres

This study aimed to systematically study the characterize of retinal damage induced by 525 nm laser irradiation at different power densities through multimodal assessment methods, including structural, functional and cytokine analyses. A total of 24 rabbits were exposed to laser irradiation at …

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Unveiling CCL2 and CXCL1: Key biomarkers and therapeutic targets in idiopathic pulmonary fibrosis.

Jing Pan, Guanhua Li, Yuanyuan Pu, Peilin Li et autres

Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive lung disease characterized by fibrosis and impaired lung function. Understanding the molecular mechanisms underlying IPF is crucial for developing effective therapeutic strategies. This study aims to identify differentially expressed genes (DEGs) in alveolar macrophages …

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Role of Golgi stress-induced ferroptosis on vascular dysfunction after traumatic hemorrhagic shock through connexin43-SLC7A11 pathway

Zhu Yingguo, Xiaoyong Peng, Lei Yan, Ling Guo et autres

The results highlight the important role of Golgi stress and ferroptosis in traumatic hemorrhagic shock-induced vascular dysfunction and inhibition of Golgi stress and its target pathway (connexin43-SLC7A11 pathway) may be the potential therapeutic target.

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Engineering triple synergistic coupling effects in g-C₃N₄-supported axially coordinated Ru single atoms/clusters to enhance multienzyme-mimicking activity for delaying osteoarthritis

Shihui Xiao, Guanhua Li, Junxu Yang, Ji Luo et autres

Excessive chondrocyte-derived reactive oxygen/nitrogen species (RONS) disrupt redox homeostasis, leading to osteoarthritis (OA) progression. Nanozymes that mimic antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) offer a promising therapeutic strategy for OA by regulating the redox microenvironment. …

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Enhanced infection prevention and control interventions decreased carbapenem-resistant Acinetobacter baumannii colonization and infection in an intensive care unit: a 4-year retrospective study

Bing Tian Zhao, Q Wang, Jinling Lu, Yue Fu et autres

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FBLN2 promoter hypermethylation: a negative prognostic biomarker and anti-PD-1 response predictor in clear cell renal cell carcinoma via high-throughput CpG Island screening

Wenfeng Liao, Lianzi Yu, Lufang Zhang, Jie Shao et autres

BACKGROUND: Clear cell renal cell carcinoma (ccRCC), with rising incidence globally, shows heterogeneous responses to immune checkpoint blockade (ICB). DNA methylation dysregulation impacts tumor immunity, necessitating predictive CpG methylation biomarkers for ICB efficacy. METHODS: Genome-wide methylation profiling (TCGA/GEO) identified prognostic promoter CpG …

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Rolling bearing fault diagnosis in noisy environments using Channel-Time parallel attention networks

Guanhua Li, Menghan Chen, Yu-Chen Lu, Yuxuan Zhang

In Industry 4.0 intelligent manufacturing, rolling bearings serve as core components of rotating machinery. Their health status directly impacts the safety and reliability of entire manufacturing systems. However, existing fault diagnosis methods face critical challenges in noisy environments, including layer-wise feature information …

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Strategic defect engineering and valence modulation in B-doped CeO2 nanoparticles for highly sensitive and reliable electrochemical detection of p-nitrophenol

Hao-Ran Li, Huan Xu, Zi-Yi Zheng, Guanhua Li et autres

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High electron transfer efficiency accordion-shaped HNiZn heterostructure nanozyme for low-temperature photo-catalytic enhanced therapy of bacterial infection wounds

Hanjie Wang, Xinqi Guo, Ying Tan, Junxu Yang et autres

Bacterial and drug-resistant bacterial infections pose significant challenges to the treatment of skin wounds. Among various non-antibiotic strategies, nanozymes which mimic the activities of natural bioenzymes and possess broad-spectrum antibacterial properties, hold promise for antibacterial therapy in infected wounds. However, the catalytic …

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