Jennifer A. Gethin

Reduced alpha power predicts recurrence risk in major depressive disorder

Amy Tong, Roland Zahn, Jennifer A. Gethin, Wael El-Deredy et autres

Background: A high proportion of individuals with major depressive disorder (MDD) develop recurrent episodes. A better understanding and the identification of markers of recurrence risk are needed to develop prophylactic treatments and to support treatment decisions. Electroencephalography (EEG) is a scalable approach …

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Subgenual cingulate-amygdala functional disconnection and vulnerability to melancholic depression

Clifford I. Workman, Karen E. Lythe, Shane McKie, Jorge Moll et autres

The syndromic heterogeneity of major depressive disorder (MDD) hinders understanding of the etiology of predisposing vulnerability traits and underscores the importance of identifying neurobiologically valid phenotypes. Distinctive fMRI biomarkers of vulnerability to MDD subtypes are currently lacking. This study investigated whether remitted …

gb, br (code pays fourni par la source)

A novel resting-state functional magnetic resonance imaging signature of resilience to recurrent depression

Clifford I. Workman, Karen E. Lythe, Shane McKie, Jorge Moll et autres

Background: A high proportion of patients with remitted major depressive disorder (MDD) will experience recurring episodes, whilst some develop resilience and remain in recovery. The neural basis of resilience to recurrence is elusive. Abnormal resting-state connectivity of the subgenual cingulate cortex (sgACC) …

gb, br (code pays fourni par la source)

Subgenual activation and the finger of blame: individual differences and depression vulnerability

Karen E. Lythe, Jennifer A. Gethin, Clifford I. Workman, Matthew A. Lambon Ralph et autres

Abstract Background Subgenual cingulate cortex (SCC) responses to self-blaming emotion-evoking stimuli were previously found in individuals prone to self-blame with and without a history of major depressive disorder (MDD). This suggested SCC activation reflects self-blaming emotions such as guilt, which are central …

gb, br (code pays fourni par la source)

Early life stress explains reduced positive memory biases in remitted depression

Jennifer A. Gethin, Karen E. Lythe, Clifford I. Workman, A.R. Mayes et autres

BACKGROUND: There is contradictory evidence regarding negative memory biases in major depressive disorder (MDD) and whether these persist into remission, which would suggest their role as vulnerability traits rather than correlates of mood state. Early life stress (ELS), common in patients with …

gb, br (code pays fourni par la source)

Ventral striatal volumes correlate with individuals’ regret related to pleasure rather than duty

Tanja Jaeckle, Steven Williams, Clifford I. Workman, Karen E. Lythe et autres

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your …

A novel resting-state functional magnetic resonance imaging signature of resilience to recurrent depression

Clifford I. Workman, Karen E. Lythe, Shane McKie, Jorge Moll et autres

BACKGROUND: A high proportion of patients with remitted major depressive disorder (MDD) will experience recurring episodes, whilst some develop resilience and remain in recovery. The neural basis of resilience to recurrence is elusive. Abnormal resting-state connectivity of the subgenual cingulate cortex (sgACC) …

gb, br (code pays fourni par la source)

A novel resting-state functional MRI signature of resilience to recurrent depression

Clifford I. Workman, Karen E. Lythe, Shane McKie, Jorge Moll et autres

BACKGROUND: A high proportion of patients with remitted major depressive disorder (MDD) will experience recurring episodes, whilst some develop resilience and remain in recovery. The neural basis of resilience to recurrence is elusive. Abnormal resting-state connectivity of the subgenual cingulate cortex (sgACC) …

Subgenual Cingulate–Amygdala Functional Disconnection and Vulnerability to Melancholic Depression

Clifford I. Workman, Karen E. Lythe, Shane McKie, Jorge Moll et autres

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Electrophysiological and neurocognitive correlates of self-blame and associated vulnerability to major depression

Jennifer A. Gethin

Self-blame–Selective Hyperconnectivity Between Anterior Temporal and Subgenual Cortices and Prediction of Recurrent Depressive Episodes

Karen E. Lythe, Jorge Moll, Jennifer A. Gethin, Clifford I. Workman et autres

IMPORTANCE: Patients with remitted major depressive disorder (MDD) were previously found to display abnormal functional magnetic resonance imaging connectivity (fMRI) between the right superior anterior temporal lobe (RSATL) and the subgenual cingulate cortex and adjacent septal region (SCSR) when experiencing self-blaming emotions …

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The role of self-blame and worthlessness in the psychopathology of major depressive disorder

Roland Zahn, Karen E. Lythe, Jennifer A. Gethin, Sophie M. Green et autres

BACKGROUND: Cognitive models predict that vulnerability to major depressive disorder (MDD) is due to a bias to blame oneself for failure in a global way resulting in excessive self-blaming emotions, decreased self-worth, hopelessness and depressed mood. Clinical studies comparing the consistency and …

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