Subgenual activation and the finger of blame: individual differences and depression vulnerability
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Le résumé fourni par la source
Abstract Background Subgenual cingulate cortex (SCC) responses to self-blaming emotion-evoking stimuli were previously found in individuals prone to self-blame with and without a history of major depressive disorder (MDD). This suggested SCC activation reflects self-blaming emotions such as guilt, which are central to models of MDD vulnerability. Method Here, we re-examined these hypotheses in an independent larger sample. A total of 109 medication-free participants (70 with remitted MDD and 39 healthy controls) underwent fMRI whilst judging self- and other-blaming emotion-evoking statements. They also completed validated questionnaires of proneness to self-blaming emotions including those related to internal (autonomy) and external (sociotropy) evaluation, which were subjected to factor analysis. Results An interaction between group (remitted MDD v. Control) and condition (self- v. other-blame) was observed in the right SCC (BA24). This was due to higher SCC signal for self-blame in remitted MDD and higher other-blame-selective activation in Control participants. Across the whole sample, extracted SCC activation cluster averages for self- v. other-blame were predicted by a regression model which included the reliable components derived from our factor analysis of measures of proneness to self-blaming emotions. Interestingly, this prediction was solely driven by autonomy/self-criticism, and adaptive guilt factors, with no effect of sociotropy/dependency. Conclusions Despite confirming the prediction of SCC activation in self-blame-prone individuals and those vulnerable to MDD, our results suggest that SCC activation reflects blame irrespective of where it is directed rather than selective for self. We speculate that self-critical individuals have more extended SCC representations for blame in the context of self-agency.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Subgenual activation and the finger of blame: individual differences and depression vulnerability
- Date Crossref
- 25/09/2020
- Éditeur
- Cambridge University Press (CUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Manchester Academic Health Science Centre pays non établi dans la noticeÉtablissement de santé
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University of Manchester pays non établi dans la noticeUniversité ou école supérieure
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MRC Cognition and Brain Sciences Unit pays non établi dans la noticeStructure de recherche
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University of Cambridge MRC Cognition and Brain Sciences Unit pays non établi dans la noticeUniversité ou école supérieure
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D’Or Institute for Research and Education Cognitive and Behavioral Neuroscience Unit pays non établi dans la noticeOrganisation à but non lucratif
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King's College London Institute of Psychiatry pays non établi dans la noticeUniversité ou école supérieure
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South London and Maudsley NHS Foundation Trust National Service for Affective Disorders pays non établi dans la noticeÉtablissement de santé
Manchester Academic Health Science Centre, University of Manchester et MRC Cognition and Brain Sciences Unit, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.