Fayin Li

Efficacy of Dexmedetomidine as an Adjuvant to Ropivacaine for Intercostal Nerve Block in Elderly Patients Undergoing Video-Assisted Thoracoscopic Esophagectomy: A randomized Double-Blinded Trial

Fayin Li, Pengfei Gao, Xianlong Zhang

Background: Esophagectomy is associated with significant postoperative pain and a pronounced perioperative stress response. Dexmedetomidine (DEX) has been widely recognized as an effective adjuvant to regional anesthesia across various surgical procedures. However, its efficacy and safety as an adjuvant to ropivacaine in …

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Inhibitory role of remifentanil in hepatic ischemia-reperfusion injury through activation of Fmol/Parkin signaling pathway: A study based on network pharmacology analysis and high-throughput sequencing

Yisi Chen, Jun Zhang, Fayin Li

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Propofol Relieves Neuropathic Pain Caused by Chronic Contraction Injury in the Spinal Cord

Yisi Chen, Jun Zhang, Fayin Li

The objective of this study is to explore the regulating pathway of propofol in alleviating neuropathic pain caused by chronic contraction injury.Forty-five rats were randomly divided into three groups: blank group (untreated, 3 groups, n=15), isoflurane group (general anesthesia of plantar incision, …

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MiR-122-5p suppresses neuropathic pain development by targeting PDK4

Lanlan Wan, Zhen Su, Fayin Li, Pengfei Gao et autres

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Amorfrutins Relieve Neuropathic Pain through the PPARγ/CCL2 Axis in CCI Rats

Pengfei Gao, Jiayu Wang, Zhen Su, Fayin Li et autres

Neuropathic pain is a public health problem. Although many pharmaceuticals are used to treat neuropathic pain, effective and safe drugs do not yet exist. In this study, we tested nociceptive responses in CCI rats, and ELISA assay was performed to examine the …

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Dexmedetomidine Attenuates Neuroinflammatory–Induced Apoptosis after Traumatic Brain Injury via Nrf2 signaling pathway

Fayin Li, Xiaodong Wang, Zhijie Zhang, Xianlong Zhang

OBJECTIVE: Dexmedetomidine (DEX) exhibits neuroprotective effects as a multifunctional neuroprotective agent in numerous neurological disorders. However, in traumatic brain injury (TBI), the molecular mechanisms of these neuroprotective effects remain unclear. The present study investigated whether DEX, which has been reported to exert …

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Breviscapine provides a neuroprotective effect after traumatic brain injury by modulating the Nrf2 signaling pathway

Fayin Li, Xiaodong Wang, Zhijie Zhang, Pengfei Gao et autres

Breviscapine (BVP) has been widely used in the treatment of several systemic diseases, including those of the cardiovascular and cerebrovascular systems. But, few studies have looked at the neuroprotective effects of BVP and its potential effect in treating traumatic brain injury (TBI). …

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Dexmedetomidine reduces oxidative stress and provides neuroprotection in a model of traumatic brain injury via the PGC-1α signaling pathway

Fayin Li, Xiaodong Wang, Zhi-Kui Deng, Xianlong Zhang et autres

The protective effects of dexmedetomidine (DEX) mediated by reductions of oxidative stress, mitochondrial damage and disintegration have been demonstrated in many injury models. However, whether DEX has a beneficial effect on traumatic brain injury (TBI) remains unknown. In this study, the neuroprotective …

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The miR-31-SOX10 axis regulates tumor growth and chemotherapy resistance of melanoma via PI3K/AKT pathway

Ying Zheng, Yong Sun, Yi Liu, Xianlong Zhang et autres

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PPARγ activation ameliorates postoperative cognitive decline probably through suppressing hippocampal neuroinflammation in aged mice

Zhijie Zhang, Hongmei Yuan, Huatang Zhao, Bin Qi et autres

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Berberine alleviates postoperative cognitive dysfunction by suppressing neuroinflammation in aged mice

Zhijie Zhang, Xiuhua Li, Fayin Li, Lijun An

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Incidence and risk factors of hypotension after spinal anesthesia induction in 1 000 patients

Feng Xu, Fayin Li, Xianlong Zhang

The clinical parameters of 1 000 patients undergoing spinal aesthesia were recorded and analyzed.Hypotension fulfilling the predefined criteria occurred in 173 patients.The logistic regression analysis revealed that the regression coefficients of height, weight and amount of fluid infusion during anesthesia were negative …

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