Alexander Hart

Topography of Regional Cerebral GABA A Receptor Availability in Parkinson's Disease Patients With Freezing of Gait

Alexander Hart, Prabesh Kanel, Jaimie Barr, Giulia Carli et autres

ABSTRACT We aimed to explore the relationship between regional gamma‐aminobutyric acid (GABA A ) receptor availability, measured with [ 11 C]‐flumazenil brain positron emission tomography (PET) and freezing of gait in patients with Parkinson's disease. Freezing of gait is a significant mobility …

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Characterizing patients with chronic scrotal content pain: a retrospective review of clinical presentations

Jacob Lam, Emily Solsrud, Alexander Hart, Abigail E. Moore et autres

Background: Men with chronic scrotal content pain (CSCP) commonly present to various providers within the healthcare system. Despite its prevalence, little research has been done to understand risk factors for the development of CSCP. In many cases, the cause of pain is …

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Association of Terazosin, Doxazosin, or Alfuzosin Use and Risk of Dementia With Lewy Bodies in Men

Alexander Hart, Georgina M. Aldridge, Qiang Zhang, Nandakumar S. Narayanan et autres

BACKGROUND AND OBJECTIVES: Terazosin, doxazosin, and alfuzosin (Tz/Dz/Az) are α-1 adrenergic receptor antagonists that also bind to and activate a key adenosine triphosphate (ATP)-producing enzyme in glycolysis. It is hypothesized that the increase in energy availability in the brain may slow or …

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Rurality modifies the association between symptoms and the diagnosis of amyotrophic lateral sclerosis

Alexander Hart, Andrea Swenson, Nandakumar Narayanan, Jacob E. Simmering

OBJECTIVE: We utilized national claims-based data to identify the change in odds of diagnosis of ALS following possible-ALS-symptoms-and whether the change varies in urban/rural areas. METHODS: Insurance claims were obtained from the Merative MarketScan databases, 2001-2021 in the United States. Individuals with …

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Lower risk of dementia with Lewy bodies among users of glycolysis enhancing drugs in a new user, active comparator design

Alexander Hart, Georgina M. Aldridge, Qiang Zhang, Nandakumar S. Narayanan et autres

Abstract Background Terazosin, doxazosin, and alfuzosin (Tz/Dz/Az) are α-1 adrenergic receptor antagonists that also bind to and activate a key ATP-producing enzyme in glycolysis. Recent work has suggested a potentially neuroprotective effect of use of Tz/Dz/Az in Parkinson’s disease in both animal …

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Rurality Modifies the Association Between Symptoms and the Diagnosis of Amyotrophic Lateral Sclerosis

Alexander Hart, Andrea Swenson, Nandakumar S. Narayanan, Jacob E. Simmering

Abstract Objective We utilized national claims-based data to identify the change in hazard of diagnosis of ALS following a possible ALS-related diagnosis (e.g., falls) and whether the change in hazard varies whether the patient lives in an urban or rural area. Methods …

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Vernix caseosa peritonitis: a novel case with colonic perforation

Mavis Orizu, Alexander Hart, Andrew MacLachlan, Matthew James McGuinness et autres

The New Zealand Medical Journal (NZMJ) is the principal scientific journal for the medical profession in New Zealand. The Journal has become a fundamental resource for providing research and written pieces from the health and medical industry.

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Patterns of Care and Outcomes of Rectal Cancer Patients from the Iowa Cancer Registry: Role of Hospital Volume and Tumor Location

Paolo Goffredo, Alexander Hart, Catherine G. Tran, Amanda R. Kahl et autres

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COVID-19 Increased Residency Applications and How Virtual Interviews Impacted Applicants

Alex M. Meyer, Alexander Hart, Jerrod N. Keith

Background The number of residency applications submitted by medical students has risen at an alarming rate, causing increased cost of applications and subsequent interview travel. These both contribute to increased cost for medical students. In light of these concerns, specialty governing bodies …

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Association between preoperative serum albumin levels with risk of death and postoperative complications after bariatric surgery: a retrospective cohort study

Alexander Hart, Yangbo Sun, Tyler J. Titcomb, Buyun Liu et autres

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A Genotype–Phenotype Analysis of Glutathione Peroxidase 4 in Human Atrial Myocardium and Its Association with Postoperative Atrial Fibrillation

Islam A. Berdaweel, Alexander Hart, Andrew J. Jatis, Nathan Karlan et autres

Heterogeneity in the incidence of postoperative atrial fibrillation (POAF) following heart surgery implies that underlying genetic and/or physiological factors impart a higher risk of this complication to certain patients. Glutathione peroxidase-4 (GPx4) is a vital selenoenzyme responsible for neutralizing lipid peroxides, mediators …

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Surgical management for giant bladder leiomyosarcoma

Alexander Hart, Charles H. Schlaepfer, Neha Dhungana, Mohammed Milhem et autres

While urothelial carcinoma is the most common histologic type of bladder cancer in the United States, leiomyosarcoma is a rare and aggressive variant. The rarity of bladder leiomyosarcoma results in uncertainty regarding the optimal treatment pathway. We report on a patient with …

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