Prabesh Kanel

Topography of Regional Cerebral GABA A Receptor Availability in Parkinson's Disease Patients With Freezing of Gait

Alexander Hart, Prabesh Kanel, Jaimie Barr, Giulia Carli et autres

ABSTRACT We aimed to explore the relationship between regional gamma‐aminobutyric acid (GABA A ) receptor availability, measured with [ 11 C]‐flumazenil brain positron emission tomography (PET) and freezing of gait in patients with Parkinson's disease. Freezing of gait is a significant mobility …

us, no (code pays fourni par la source)

Pathology and Genetics in a Global Cohort of Parkinsonian Disorders

Lesley Y. Wu, Tessa du Toit, Tatiana Georgiades, Eleanor J. Stafford et autres

Importance: Accurate diagnosis of neurodegenerative movement disorders is challenging because of a lack of in vivo biomarkers, overlapping clinical features, and a delay in the emergence of pathognomonic features. Objective: To evaluate clinicopathological correlation, diagnostic accuracy, genetic association with pathology, and ancestry-related …

gb, us, de, au, it (code pays fourni par la source)

Cholinergic system changes in levodopa-unresponsive freezing of gait and failure of goal-directed motor behavior in Parkinson's disease

Nicolaas I. Bohnen, Stiven Roytman, Giulia Carli, Kelvin L. Chou et autres

Brain cholinergic systems changes are implicated in the pathophysiology of postural instability and gait difficulties in Parkinson's disease. The presence of postural instability and gait difficulties is associated with cholinergic terminal deficits or downregulation of cholinergic neurotransmission. Preservation or upregulation of cholinergic …

us, fr (code pays fourni par la source)

White matter lesions disrupt cholinergic pathways important for cognition in Parkinson’s disease

Giulia Carli, Taylor Brown, Fotini Michalakis, Abigail Biddix et autres

White matter lesions are associated with cognitive impairment in Parkinson's disease, but the underlying neurobiological mechanisms remain unclear. One hypothesis is that strategically located white matter lesions disrupt long-range white-matter pathways crucial for cognitive functioning, particularly cholinergic projections from the basal forebrain, …

us, fr (code pays fourni par la source)

Asymmetric Cholinergic Basal Forebrain Atrophy Marks Freezing of Gait in Parkinson's Disease

Chesney E. Craig, Prabesh Kanel, Nicola J. Ray, Nicolaas I. Bohnen

Freezing of gait (FoG) and falls are among the most disabling symptoms in late-stage Parkinson's disease (PD). While right-lateralised thalamic cholinergic denervation has been linked to FoG and gait impairment, it is unclear whether similar asymmetry exists within the cortically-projecting cholinergic basal …

gb, us (code pays fourni par la source)

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman et autres

ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional …

us (code pays fourni par la source)

Cholinergic substrates of gait and postural impairments in Progressive Supranuclear Palsy

Prabesh Kanel, Giulia Carli, Stiven Roytman, Sygrid van der Zee et autres

us (code pays fourni par la source)

Harmonized Protocol for Subfield Segmentation in the Hippocampal Body on High‐Resolution In Vivo MRI From the Hippocampal Subfields Group ( HSG )

Ana M. Daugherty, Valerie A. Carr, Kelsey L. Canada, Gustaf Rådman et autres

ABSTRACT Hippocampal subfields differentially develop and age, and they vary in vulnerability to neurodegenerative diseases. Innovation in high‐resolution imaging has accelerated clinical research on human hippocampal subfields, but substantial differences in segmentation protocols impede comparisons of results across laboratories. The Hippocampal Subfields …

us, se, de, fr, ca, hu (code pays fourni par la source)

Author response for "Asymmetric Cholinergic Basal Forebrain Atrophy Marks Freezing of Gait in Parkinson’s Disease"

Chesney E. Craig, Prabesh Kanel, Nicola J. Ray, Nicolaas I. Bohnen

Polynomial Progression Subtype Inference Algorithm CodeOcean

August Van Hout, Stiven Roytman, Giulia Carli, Prabesh Kanel et autres

Longitudinal assessments are currently the gold standard for modeling progression of diseases, but they delay prognosis and increase burden on patients and healthcare systems. Cross-sectional inference offers a valuable alternative, enabling earlier patients’ stratification and broader accessibility. Initial success in this direction …

us (code pays fourni par la source)

Harmonized Protocol for Subfield Segmentation in the Hippocampal Body on High‐Resolution In Vivo MRI From the Hippocampal Subfields Group ( HSG )

Ana M. Daugherty, Valerie A. Carr, Kelsey L. Canada, Gustaf Rådman et autres

de (code pays fourni par la source)

Polynomial Progression Subtype Inference Algorithm CodeOcean

August Van Hout, Stiven Roytman, Giulia Carli, Prabesh Kanel et autres

Longitudinal assessments are currently the gold standard for modeling progression of diseases, but they delay prognosis and increase burden on patients and healthcare systems. Cross-sectional inference offers a valuable alternative, enabling earlier patients’ stratification and broader accessibility. Initial success in this direction …

us (code pays fourni par la source)