Faradhina Salfa Nindya

EDUKASI DAN PEMERIKSAAN KULIT: UPAYA MENINGKATKAN KESADARAN MASYARAKAT TENTANG PERAWATAN KULIT

Wahyu Widowati, Teresa Liliana Wargasetia, Mariska Elisabeth, Mathelda Weni Haryanti et autres

Penuaan kulit merupakan proses alami yang tidak dapat dihindari oleh setiap individu. Proses penuaan ini dapat dipengaruhi secara intrinsik maupun ekstrinsik. Faktor penuaan ekstrinsik yang berlebih dapat memberikan pengaruh signifikan pada kesehatan kulit. Di saat bersamaan, sejumlah masyarakat belum mengetahui pentingnya menjaga …

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Innovating Glioma Therapy Using Secretions from Umbilical Cord Mesenchymal Stem Cells to Target Homeobox and Growth Factor Genes

Ahmad Faried, Achmad Adam, Wahyu Widowati, Annisa Firdaus Sutendi et autres

Background: Glioblastoma is a prevalent and challenging malignant brain tumor. Secretome therapy using human umbilical cord mesenchymal stem cells (hUCMSCs) appears to be a promising treatment for glioblastoma. This study analyzed the potential of the hUCMSC secretomes (hUCMSCs-sec) for glioma therapy. Materials …

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Conditioned Medium of IGF1-Induced Human Wharton’s Jelly Mesenchymal Stem Cells Effects on Sox9 Gene Expression and Level of COL2 and IL1β in Osteoarthritic Chondrocytes

Wahyu Widowati, Hanna Sari Widya Kusuma, Rizal Azis, The Fransiska Eltania et autres

Wharton’s jelly mesenchymal stem cells (WJMSCs) hold promises for treating osteoarthritis (OA) due to their great capacity for regeneration and their accessibility. However, obstacles like poor cell survival and differentiation prevent them from being used in transplants. Thus, this study examined WJMSCs’ …

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Antioxidant and inhibitory activities of α-amylase, α-glucosidase, and G6Pase from Smallanthus sonchifolius tuber extract as a potential antidiabetic agent

Wahyu Widowati, Roro Wahyudianingsih, Fen Tih, Penny Setyawati Martioso et autres

Introduction: Diabetes mellitus (DM) is a chronic condition with free radicals and carbohydrate-hydrolyzing enzymes playing key roles in its progression. Yacon or Smallanthus sonchifolius (Poepp.) H.Rob, a low-sugar crop, has shown promising bioactivities. This research aimed to explore the antidiabetic and antioxidant …

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The Potential of Human Wharton’s Jelly Mesenchymal Stem Cells Secretome Based Topical Gel for Therapeutic Application

Wahyu Widowati, Ahmad Faried, Rimonta F. Gunanegara, Fanny Rahardja et autres

Background: Diabetic Foot Ulcer (DFU) might be worsened by neuropathy and vascular issues. This condition can cause 14.3% fatality, stressing the need for effective wound healing therapy. Wound healing is a complex biological process, and human Wharton's Jelly Mesenchymal Stem Cells (hWJMSCs) …

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Wound Healing Potent of Lyophilized-Secretome Gel from Human Wharton’s Jelly Mesenchymal Stem Cells

Wahyu Widowati, Ahmad Faried, Rimonta F. Gunanegara, Fanny Rahardja et autres

Wounds that become infected can lead to serious illness or even death if left untreated. Unfortunately, current wound healing treatments don’t always work well. Achieving optimal wound healing involves the coordination of diverse cellular events facilitated by numerous growth factors, cytokines, and …

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ANTIOXIDANT POTENTIAL OF TEMULAWAK (CURCUMA XANTHORRHIZA) EXTRACT GEL AS A CANDIDATE FOR WOUND HEALING

Reghita Claudia Malau, Sri Wahyuni Nasution, Ali Napiah Nasution, Wahyu Widowati et autres

Background: The complete treatment of chronic wounds remains a significant unmet medical need. To expedite the healing of chronic wounds, numerous studies have begun to utilize gels, including hydrogels or sol-gels, which incorporate a combination of antioxidant properties. Curcuma xanthorrhiza is known …

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Potency of Clitoria ternatea L. Ethanol Extract Against IFNγ and GLUT4 Protein in Type 2 Diabetes Mellitus Rat Model

Philips Onggowidjaja, Rita Tjokropranoto, Richard Gunawan, Wahyu Widowati et autres

Diabetes Mellitus (DM) is a chronic disease caused by genetics, lifestyle, and immunology. Type 2 DM is caused by resistanceto insulin, which causes blood sugar to not be stored in glycogen. Clitoria ternatea L. (Fabaceae) flower contains a lot ofanthocyanins and has …

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Antidiabetic potential of Clitoria ternatea flowers against pancreatic ratio, protein expression of a-amylase, and gene expression of pancreatic glucagon in diabetic rats

Johan Lucianus, Lusiana Darsono, Wahyu Widowati, Djaja Rusmana et autres

Diabetes Mellitus (DM) is a hormonal disorder characterized by decreased insulin levels in the blood. The use of synthetic drugs for DM treatment is associated with various adverse effects that can harm patients, leading to an increased demand for herbal remedies. Clitoria …

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Anti-diabetes mellitus potential of butterfly pea flower (Clitoria ternatea L.) extract based on antioxidant and inhibition of a-amylase and a-glucosidase activities

Johan Lucianus, Lusiana Darsono, Wahyu Widowati, Djaja Rusmana et autres

Type-2 diabetes (T2DM) is a condition that occurs when insulin production is insufficient. The prolonged process of imperfect insulin secretion results in hyperglycemia. Hyperglycemia-induced oxidative stress exacerbates diabetes complications. a-amylase and a-glucosidase also need to be inhibited to reduce blood glucose levels. …

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Valorization of Salmo salar Skin Waste for the Synthesis of Angiotensin Converting Enzyme-1 (ACE1) Inhibitory Peptides

Heli Siti Halimatul Munawaroh, Gun Gun Gumilar, Selmi Fiqhi Khoiriah, Faradhina Salfa Nindya et autres

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Green Synthesis and Antibacterial Activity of Silver Nanoparticles: A Review

Asep Bayu Dani Nandiyanto, Annisa Moza Nabila, Faradhina Salfa Nindya, Nur'aini Berliana et autres

The purpose of this study was to determine the effect of silver nanoparticles (AgNPs) from different green synthesis medium and their various particle sizes on antibacterial activity. The article review method compares the results of 11 studies obtained from the PubMed database, …

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