Lusiana Darsono

Red Ginger Extract Nanoemulsion Potently Inhibits MCF-7 Breast Cancer Cells and Decreases Inflammation

Didik Priyandoko, Wahyu Widowati, Dwi Davidson Rihibiha, Lusiana Darsono et autres

Breast cancer (BC) known as prevalent cancer, and compounds in red ginger (Zingiber officinale var. rubrum) (RG) have potential as anticancer agents. In developing the potential of RG, developing RG nanoparticles (RGN) increases effectiveness and reduces side effects. A study aimed to …

Post COVID-19 pandemic adaptation on medical education and mental health in Indonesia: challenges and future direction

Yuda Turana, Putu Asih Primatanti, Artha Budi Susila Duarsa, Lusiana Darsono et autres

Introduction: Post-pandemic conditions demand new adaptations to medical students' learning methods for both pre-clinic and clerkship. The COVID-19 pandemic has disrupted educational institutions across the country, leading medical schools to implement online learning systems. We aim to evaluate the impact of the …

Potential of Clitoria ternatea L. Extract Towards Insulin Receptor Expression and Marker of Inflammation in Diabetes Mellitus Rats Model

Djaja Rusmana, Hartini Tiono, Wahyu Widowati, Johan Lucianus et autres

Metabolic abnormalities caused by the accumulation of human, environmental, genetic and lifestyle variables can be found in diabetes mellitus (DM). An increase in blood glucose carried on by a reduction in insulin production can also result in DM. Insulin resistance often occurs …

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Antidiabetic and hepatoprotection effect of butterfly pea flower (Clitoria ternatea L.) through antioxidant, anti-inflammatory, lower LDH, ACP, AST, and ALT on diabetes mellitus and dyslipidemia rat

Wahyu Widowati, Lusiana Darsono, Herry S. Utomo, Adilah Hafizha Nur Sabrina et autres

L.) (CTE) in diabetic and dyslipidemia rat models. Diabetes Mellitus (DM) is a chronic metabolic disorder marked by high levels of blood glucose, which can cause dyslipidemia and liver damage as a result of oxidative stress. CTE, a natural substance, is recognized …

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Antidiabetic potential of Clitoria ternatea flowers against pancreatic ratio, protein expression of a-amylase, and gene expression of pancreatic glucagon in diabetic rats

Johan Lucianus, Lusiana Darsono, Wahyu Widowati, Djaja Rusmana et autres

Diabetes Mellitus (DM) is a hormonal disorder characterized by decreased insulin levels in the blood. The use of synthetic drugs for DM treatment is associated with various adverse effects that can harm patients, leading to an increased demand for herbal remedies. Clitoria …

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Antidiabetic, antidyslipidemia and renoprotector potency of butterfly pea flower extract (Clitorea ternatea L.) in diabetes mellitus and dyslipidemia rats model

Wahyu Widowati, Lusiana Darsono, Maria R Natariza, Novaldo W Waluyo et autres

Background: L.) has phenolic and flavonoid compounds which have the potential as herbal medicines for antidiabetics. Aim: The purpose of this study is to examine the potential of butterfly pea flower extract (BPE) as an antidiabetic, anti-dyslipidemia, and renoprotection. Methods: L.) induced …

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Anti-diabetes mellitus potential of butterfly pea flower (Clitoria ternatea L.) extract based on antioxidant and inhibition of a-amylase and a-glucosidase activities

Johan Lucianus, Lusiana Darsono, Wahyu Widowati, Djaja Rusmana et autres

Type-2 diabetes (T2DM) is a condition that occurs when insulin production is insufficient. The prolonged process of imperfect insulin secretion results in hyperglycemia. Hyperglycemia-induced oxidative stress exacerbates diabetes complications. a-amylase and a-glucosidase also need to be inhibited to reduce blood glucose levels. …

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The Ethanolic Extract of Clitoria ternatea L. Flower Attenuates SMADs and REGs Regulation in Dyslipidemia and Diabetes Mellitus Rat Model

Lusiana Darsono, Wahyu Widowati, Johan Lucianus, Shiela Stefani et autres

Dyslipidemia is a condition of fat metabolism disorders with increased levels of total cholesterol (CHOL), triglycerides (TG), low-density lipoprotein (LDL), and low high-density lipoprotein (HDL). Dyslipidemia is often found in patients with type 2 diabetes mellitus (DMT2) with a higher risk of …

Anti-hyperlipidemic effect of Indonesian mangosteen peel extract in dyslipidemia-induced rats

Lusiana Darsono, Jo Suherman, Wahyu Widowati, Hanna Sari Widya Kusuma

Dyslipidemia, is due to an increase in blood lipid levels, which include cholesterol, triglycerides and low-density lipoprotein. Dyslipidemia is expected to remain as a major risk factor for cardiovascular diseases, diabetic and atherosclerosis. Mangosteen is an antioxidant agent that can exhibit a …

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Butterfly pea flower (Clitoria ternatea L.) extract displayed antidiabetic effect through antioxidant, anti-inflammatory, lower hepatic GSK-3β, and pancreatic glycogen on Diabetes Mellitus and dyslipidemia rat

Wahyu Widowati, Lusiana Darsono, Johan Lucianus, Edwin Setiabudi et autres

Diabetes Mellitus (DM) is hyperglycemic or elevated blood glucose level and deficiency of insulin level. DM treatment using synthetic drugs has several complexities, side effects. Reducing the side effects of synthetic drugs, the utilization of herbal medicines is increasingly in demand. Butterfly …

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REGULATION OF ADIPOGENESIS AND KEY ADIPOGENIC GENE EXPRESSION BY MANGOSTEEN PERICARP EXTRACT AND XANTHONES IN 3T3-L1 CELLS

Wahyu Widowati, Lusiana Darsono, Jo Suherman, Ervi Afifah et autres

Obesity is one of the risk factors for atherosclerosis and its fat occurrence and development are associated with fat accumulation and adipocyte differentiation. Thus, the suppression of adipocyte differentiation can be a potential anti-obesity approach to this health concern. This study examined …

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Anti-inflammatory properties of mangosteen peel extract on the mice gingival inflammation healing process

Khairani Putri, Lusiana Darsono, Henry Yonatan Mandalas

Introduction: Mangosteen (Garcinia Mangostana L.) peel extract has widely used in the pharmaceutical field due to its anticancer, anti-inflammatory, antibacterial, and immunity boost properties. It had been proofed to be able to prevent and reduce the amount of plaque and cure gingivitis. …

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