Shizhu Jin

YTHDF1/SLC39A4 signaling axis promotes gastric cancer cell proliferation by suppressing cuproptosis ex vivo and in vitro

Jingying Su, Jihan Qi, Binhua Xu, Jiaxin Wang et autres

Gastric cancer (GC) continues to be a major contributor to global cancer mortality, underscoring the need to elucidate its molecular mechanisms to develop effective therapies. Cuproptosis, a copper-dependent form of cell death, exhibits tumor-suppressive effects in GC. Clinical specimens revealed elevated expression …

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Unveiling and verification of mitochondria-related genes as potential diagnostic biomarkers in ulcerative colitis based on bioinformatics analysis and experimental validation

Hongliang Chen, Ning Li, Xuerong Liu, Ming-Yu Ran et autres

Immune dysregulation is a pathogenic factor in ulcerative colitis (UC), in which mitochondrial involvement is increasingly recognized. This study aimed to construct a diagnostic model using mitochondria-related genes, identify new target genes, and illuminate the roles of mitochondria-related genes in energy metabolism, …

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Identification and validation of mitochondrial ferroptosis and immune microenvironment-related hub biomarkers in liver cirrhosis by integrated bioinformatics analysis

PengChao Deng, Ram Prasad Chaulagain, Babalola Deborah Oluwaseun, JiaXin Wang et autres

Background Liver cirrhosis represents a significant challenge to global public health. However, reliable biological markers for diagnosing liver cirrhosis are lacking in clinical practice. Methods Transcriptome data from liver cirrhosis patients were acquired from the Gene Expression Omnibus database to identify coexpressed …

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LncRNA SNHG12 promotes EMT and metastasis of colorectal cancer via regulating TGF-β/Smad2/3 signaling pathway

Lei Zhao, Xiaoli Sun, Hongliang Chen, Ning Li et autres

OBJECTIVE: In this study, we aimed to explore the molecular mechanism of SNHG12 promoting colorectal cancer (CRC) progression. METHODS: Bioinformatics technology was utilized to identify SNHG12-targeted mRNA and the correlation with the prognosis of CRC patients. Transfected sequence of knockdown SNHG12 in …

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Identification of Key Gene Related to Matrisome in HBV‐Associated Liver Cirrhosis via Bioinformatics Analysis

Ram Prasad Chaulagain, Yelona Shrestha, Khuzin Dinislam, Shizhu Jin

Background: Hepatitis B virus (HBV)–associated liver cirrhosis, characterized by progressive fibrosis and regenerative nodule formation, remains a critical public health concern due to its high risk of progression to hepatocellular carcinoma (HCC). The matrisome—comprising extracellular matrix (ECM) components such as collagens, laminins, …

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GABPA-Mediated Expression of HPN-AS1 Facilitates Cell Apoptosis and Inhibits Cell Proliferation in Hepatocellular Carcinoma by Promoting eIF4A3 Degradation

Ying Chuan Hu, Xiaoli Sun, Bing Li, Ruilling Xu et autres

Hepatocellular carcinoma (HCC) represents a common neoplasm that presents a substantial worldwide health challenge. Nevertheless, the involvement of HPN-AS1 in HCC remains unknown. The quantitative reverse transcription polymerase chain reaction (qRT-PCR) assay was utilized to measure HPN-AS1 expression in HCC. The GABPA …

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Stimulation by exosomes from hypoxia-preconditioned hair follicle mesenchymal stem cells facilitates mitophagy by inhibiting the PI3K/AKT/mTOR signaling pathway to alleviate ulcerative colitis

Ning Li, Леи Жао, Xinyu Geng, Jingyang Liu et autres

This study revealed a vital role for Hy-Exos in suppressing inflammatory progression in UC and suggested that miR-214-3p is a potential critical target for Hy-Exos in alleviating UC.

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Development and validation of a blood routine-based extent and severity clinical decision support tool for ulcerative colitis

Hongliang Chen, Xindi Lin, Xinyue Pan, Hongyu Xu et autres

Monitoring extent and severity is vital in the ulcerative colitis (UC) follow-up, however, current assessment is complex and low cost-effectiveness. We aimed to develop a routine blood-based clinical decision support tool, Jin's model, to investigate the extent and severity of UC. The …

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BMSCs alleviate liver cirrhosis by regulating Fstl1/Wnt/β-Catenin signaling pathway

Hanjing Zhangdi, Xinyu Geng, Ning Li, Ruiling Xu et autres

Researchers have shown that bone mesenchymal stem cells (BMSCs) can alleviate the progression of liver cirrhosis; however, it is unclear how exactly BMSCs function to cure liver disease. In this study, we used bioinformatics methods to assess differentially expressed genes (DEGs) in …

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From Phenomenon to Essence: A Newly Involved lncRNA Kcnq1ot1 Protective Mechanism of Bone Marrow Mesenchymal Stromal Cells in Liver Cirrhosis

Hanjing Zhangdi, Yanan Jiang, Yang Gao, Shuang Li et autres

Abstract Bone marrow mesenchymal stromal cells (BMSCs) have a protective effect against liver cirrhosis. Long noncoding RNAs (lncRNAs) play crucial roles in the progression of liver cirrhosis. Therefore, it is aimed to clarify the lncRNA Kcnq1ot1 involved protective mechanism of BMSCs in …

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Characterization of the metabolic alteration-modulated tumor microenvironment mediated by TP53 mutation and hypoxia

Kunpeng Luo, Zhipeng Qian, Yanan Jiang, Dongxu Lv et autres

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Targeting EIF5A improves liver fibrosis by inhibiting mitochondrial function of hepatic stellate cells

Yuzhu Di, Yanan Jiang, Fengnan Zhi, Ying Chuan Hu et autres

Abstract Background: Liver fibrosis (LF) is the pathological basis of a majority of chronic liver diseases, characterized by excessive activation of hepatic stellate cells (HSCs), inflammatory disorders and progressive scarring of the hepatic interstitial. Recently, sing-cell RNA sequencing (scRNA-seq) technology highlighted a …

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