Min Jiang

[Research Progress on Glycolytic Reprogramming and Lactylation Crosstalk in Tumors].

Yilin Feng, Yu Sun, Xu Hao, H. J. Yang et autres

Metabolic reprogramming is a hallmark of cancer, with the Warburg effect-driven aerobic glycolysis leading to a substantial accumulation of lactate in the tumor microenvironment. For a long time, lactate was considered a mere metabolic end product; however, recent studies have found that …

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o-Phenanthrenequinone-mediated guanidinium nucleophilic attack of tanshinone IIA to Arg145 on Annexin A2 inhibits endothelial-monocyte adhesion and contributes to relieve atherosclerosis

Wenjuan Liu, Yixu Wang, Sihan Xu, Jiawei Li et autres

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SIRT3 regulates PDHA1 acetylation in HUVECs to modulate inflammation and pyroptosis under clinorotation

Min Jiang, Junjie Shao, Kun‐Yi Andrew Lin, Lejian Lin et autres

Microgravity-induced endothelial inflammation contributes to cardiovascular dysfunction in astronauts, but the metabolic mechanisms involved are not fully defined. Sirtuin-3 (SIRT3), a mitochondrial deacetylase, regulates cellular metabolism and redox balance. The results demonstrate that two-dimensional clinorotation-induced simulated microgravity suppresses SIRT3 in human umbilical …

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Curcumin inhibits HIV-1 by modulating FOXP3 and suppressing CCR5 via PI3K/AKT and JAK/STAT pathways

Qing Li, Wenjin Jim Zheng, Qingya Li, Min Jiang et autres

Despite advances in antiretroviral therapy, HIV-1 persistence and immune dysregulation remain unresolved challenges. Here, we demonstrate that curcumin, a low-toxicity natural compound, can inhibit HIV-1 through simultaneous inhibition of the PI3K/AKT and JAK/STAT pathways, leading to downregulation of the viral co-receptor CCR5 …

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Predictive role of neutrophil percentage-to-albumin ratio in acute fulminant myocarditis patients receiving extracorporeal membrane oxygenation

Jingjing Zhou, Junjie Shao, Shuai Yue, Hao-Jie Yan et autres

BACKGROUND: Venoarterial extracorporeal membrane oxygenation induces an inflammatory response upon initiation. The neutrophil percentage-to-albumin ratio is a promising biomarker for predicting mortality in patients with systemic inflammation. This study aimed to investigate the association between neutrophil percentage-to-albumin ratio and in-hospital mortality in …

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Analysis of the Pathogenesis of Secondary Airflow Limitation in Tuberculosis based on ILC3 Chemotaxis

Wei Zhao, Yide Wang, Dan Xu, Jing Jing et autres

Introduction Tuberculosis-associated obstructive pulmonary disease (TOPD) remains poorly understood; accumulating evidence implicates innate lymphoid cells (ILCs), especially group 3 (ILC3), in post-tuberculous airway remodelling. We aimed to clarify whether CXCL13-CXCR5–directed ILC3 chemotaxis contributes to secondary airflow limitation. Methods In a case-control study, …

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Mitochondrial Calcium Uniporter‐Mediated Regulation of the SIRT3 / GSK3β /β‐Catenin Signaling Pathway in Vascular Remodeling

Min Jiang, Lejian Lin, Shuai Yue, Hao-Jie Yan et autres

ABSTRACT Calcium homeostasis plays a crucial role in regulating the phenotype of vascular smooth muscle cells (VSMCs) and vascular remodeling. This study aims to investigate the role of the mitochondrial calcium uniporter (MCU), which facilitates the uptake of Ca 2+ into the …

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Risk factors for complications of tissue expansion: An updated systematic review and meta-analysis

Min Jiang, Xinzhu Liu, Dawei Li, Feng Baigong et autres

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Narrative review of 3D bioprinting for the construction of in vitro tumor models: present and prospects

Jun Wei Zhu, Yi Gao, Min Jiang, Hong Xia Yin

Background and Objective: The conventional in vitro research on tumor mechanisms is typically based on two-dimensional (2D) culture of tumor cells, which has many limitations in replicating in vivo tumorigenesis processes. In contrast, the three-dimensional (3D) bioprinting has paved the way for …

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Functional design of caprolactam for aliphatic polyamide with enhanced flame retardancy, mechanical robustness, and chemical recyclability

Fengming He, Yan‐Fang Xiao, Qin Zhang, Min Jiang et autres

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A Machine Learning Model Predicts Future Infections in Elderly Patients in the Intensive Care Unit Who Carry Carbapenem-Resistant Enterobacteriaceae by Analyzing Easily Accessible Electronic Medical Records.

Fei Sun, Huihui Zhou, Min Jiang, Zhaoxin Xia et autres

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Synergistic Mitochondrial Genotoxicity of Carbon Dots and Arsenate in Earthworms Eisenia fetida across Generations: The Critical Role of Binding

Yuhan Deng, Min Jiang, Maoqiu Wang, Kewei Ren et autres

The escalating utilization of carbon dots (CDs) in agriculture raises ecological concerns. However, their combined toxicity with arsenic remains poorly understood. Herein, we investigated the combined mitochondrial genotoxicity of CDs and arsenate at environmentally relevant concentrations across successive earthworm generations. Iron-doped CDs …

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