Enqiang Mao

Unfractionated Heparin and Low‐Molecular‐Weight Heparin in Sepsis: Anti‐Inflammatory and Anticoagulant Effects Versus No Anticoagulation—A Propensity Score‐Matched Analysis

Peili Chen, Yi Yao, Bing Zhao, Yuan An et autres

BACKGROUND: Given the controversy surrounding anticoagulation therapy in sepsis, this study evaluated the efficacy of unfractionated heparin (UFH) and low-molecular-weight heparin (LMWH) compared with no anticoagulation in sepsis management, considering their potential benefits beyond anticoagulation. METHODS: In this retrospective cohort study, 1362 …

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[Expression of Concern] lncRNA FLVCR1‑AS1 drives colorectal cancer progression via modulation of the miR‑381/RAP2A axis

Yi Han, Xiaoyan Wang, Enqiang Mao, Boyong Shen et autres

Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that, regarding the TUNEL assay experiments shown in Fig. 2E on p. 5, the Merge panels for the shFLVCR1‑AS1 experiments shown for the Caco‑2 and …

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Bulk RNA-seq of skeletal muscle reveals the role of ZBED6 in sepsis-induced muscle atrophy in minipigs

Huan Liu, Wen Shi, Yanjun Zheng, Yihui Wang et autres

Sepsis is a severe disease and induces skeletal muscle atrophy, which has a significant impact on patients. Moreover, the onset and severity of muscle atrophy can vary across different anatomical regions during sepsis. Our previous study demonstrated that ZBED6 knockout not only …

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International Association of Pancreatology Revised Guidelines on Acute Pancreatitis 2025: Supported and Endorsed by the American Pancreatic Association, European Pancreatic Club, Indian Pancreas Club, and Japan Pancreas Society

Andrea Párniczky, Alexandra Mikó, Aliye Uç, Anand Narayan Singh et autres

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Development and validation of a prediction model for in‐hospital mortality in patients with sepsis

Wen Shi, Mengqi Xie, Enqiang Mao, Zhitao Yang et autres

BACKGROUND: Sepsis, a life-threatening condition marked by organ dysfunction due to a dysregulated host response to infection, involves complex physiological and biochemical abnormalities. AIM: To develop a multivariate model to predict 4-, 6-, and 8-week mortality risks in intensive care units (ICUs). …

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Impact of metagenomics next-generation sequencing on etiological diagnosis and early outcomes in sepsis

Feixiang Xu, Chen Chen, Su Lu, Mingming Xue et autres

BACKGROUND: Clinical implications of metagenomics next-generation sequencing (mNGS) in sepsis have not been fully evaluated. This study aimed to determine the diagnostic, therapeutic, and prognostic impacts of mNGS in sepsis. METHODS: This multicenter prospective study was conducted at 19 sites in China …

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Global, regional, and national burdens of PUD in women of reproductive age from 1992 to 2021: a trend analysis based on the global burden of disease study 2021

Xiaofeng Wang, Yang Song, Shanzhi Zhao, Zhitao Yang et autres

Background: Peptic ulcer disease (PUD) constitutes a significant global health concern, particularly in women of childbearing age (WCBA), who face elevated risks of severe pregnancy-associated complications. This investigation aimed to map the temporal dynamics and forecast the future incidence of PUD in …

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Metabolic shifts in tryptophan pathways during acute pancreatitis infections

Daosheng Wang, Silei Sun, Qianli Zhao, Bing Zhao et autres

Infectious complications (ICs) in acute pancreatitis (AP) are primarily driven by intestinal bacterial translocation, significantly increasing mortality and hospital stays. Despite this, the role of the gut microenvironment, particularly its metabolic aspects, in AP remains poorly understood. In this study, we investigated …

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Exploring lipidome mediated inflammatory pathways in acute pancreatitis using mendelian randomization

Wenbin Liu, Yang Song, Yuhan Li, Dava Tenzing et autres

Acute pancreatitis (AP) is a severe gastrointestinal condition with an increasing incidence of hyperlipidemic etiology. The investigation employed a two-sample, bidirectional Mendelian randomization method to investigate potential causal relationship between lipidome profiles, inflammatory mediators, and AP. Exploration of genetic variants across the …

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Neutrophil-mediated cordycepin-based nanoparticles for targeted treatment of acute lung injury

Huizhen Fan, YU Sen-yang, Jun Huang, Decui Cheng et autres

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The role of early changes in routine coagulation tests in predicting the occurrence and prognosis of sepsis

Peili Chen, Yan Ge, Huiqiu Sheng, Wenwu Sun et autres

BACKGROUND: This study aimed to explore the importance of routine coagulation tests for the early detection of sepsis and to quickly identify patients at a high risk of mortality.METHODS: This retrospective single-center study collected data from patients meeting the clinical criteria for …

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High-dose intravenous vitamin C reduce C-reactive protein levels, fluid retention, and APACHE II scores in patients with moderately severe acute pancreatitis: a prospective, randomized, double-blinded, placebo-controlled study

Bing Zhao, Wenwu Sun, Yihui Wang, Li Ma et autres

BACKGROUND: The aim of this study was to investigate whether high-dose intravenous vitamin C (HDIVC) could decrease the mortality rate within 28 days among patients moderately severe acute pancreatitis (MSAP) and severe acute pancreatitis (SAP). METHODS: In this randomized, placebo-controlled trial, patients …

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