Metabolic shifts in tryptophan pathways during acute pancreatitis infections
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Le résumé fourni par la source
Infectious complications (ICs) in acute pancreatitis (AP) are primarily driven by intestinal bacterial translocation, significantly increasing mortality and hospital stays. Despite this, the role of the gut microenvironment, particularly its metabolic aspects, in AP remains poorly understood. In this study, we investigated a cohort of patients with AP, and conducted supplemental murine studies, to explore the relationship between the gut metabolome and the development of ICs. Metabolomic analysis revealed that disruptions in gut tryptophan metabolism - especially reductions in serotonin and indole pathways - are key features associated with IC occurrence. Additionally, elevated plasma levels of tryptophan metabolites within the kynurenine pathway were identified as valuable predictive biomarkers for ICs. Mechanistic studies in murine models demonstrated that an impaired intestinal Th17 response, modulated by these tryptophan metabolites, plays a critical role in IC development. Serotonin supplementation enhanced Th17 responses, reducing IC incidence, while administration of kynurenic acid, a kynurenine metabolite, exacerbated pancreatic infections, potentially through immunosuppressive effects. These findings highlight the pivotal role of tryptophan metabolites in AP pathogenesis, emphasizing their potential as both predictive markers and therapeutic targets in IC management.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Metabolic shifts in tryptophan pathways during acute pancreatitis infections
- Date Crossref
- 10/03/2025
- Éditeur
- American Society for Clinical Investigation
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Shanghai Jiao Tong University Department of Critical Care Medicine pays non établi dans la noticeUniversité ou école supérieure
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Ruijin Hospital pays non établi dans la noticeÉtablissement de santé
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Department of Emergency pays non établi dans la noticeInstitution
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Department of Laboratory Medicine pays non établi dans la noticeStructure de recherche
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Faculty of Medical Laboratory Science pays non établi dans la noticeUniversité ou école supérieure
Department of Critical Care Medicine — Shanghai Jiao Tong University, Ruijin Hospital et Department of Emergency, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.