Hung‐Yi Chiou

Neutrophil extracellular trap levels in the prediction of adverse outcomes for hyperglycemia ischemic stroke patients

Hongyu Lin, Li-Kai Huang, Yu-Ling Li, Chung‐Fen Tsai et autres

Hyperglycemia (HG) affects nearly 50% of acute ischemic stroke (AIS) patients, regardless of diabetes mellitus (DM) status, and is associated with an adverse prognosis. Conventional HG treatments have not significantly improved prognosis, suggesting an unclear underlying mechanism. This study explores novel biomarkers …

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Sibling influence on childhood neurodevelopmental disorders: A cohort study in Taiwan

Yi-Yu Su, Chi‐Jen Chen, Mei‐Huei Chen, Ching‐Chun Lin et autres

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Analgesic Prescribing Trends of Opioids, Nonsteroidal Anti-Inflammatory Drugs, and Paracetamol in Taiwan (2001‐2020): Age-Period-Cohort Cross-Sectional Study

Chun-Ji Lin, Chia-Shuan Chang, Chih-Yi Wu, Jiun‐Yi Wang et autres

Background: Despite ongoing global changes in analgesic prescribing practices, long-term trends accounting for age, period, and cohort effects remain poorly understood in Asian populations, where opioid and nonopioid prescribing trajectories differ from those observed in Western nations. Objective: This study aimed to …

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Rising Incidence and Mortality of Colorectal Cancer Among Younger Adults: A Population‐Based Study in Taiwan, 1994–2018

Yun‐Chen Tsai, C L Wu, Tsung-I Hung, Hung‐Yi Chiou

Colorectal cancer (CRC) incidence and mortality have increased significantly in the Asia-Pacific region over the past three decades. Taiwan is not reported but presents one of the globally highest age-standardized EOCRC incidence and mortality rates. This population-based study in Taiwan from 1994 …

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AIZEN Digital Meditation Intervention for Caregiver Burnout in Taiwan—A Pilot Randomized Trial

Ying‐Erh Chen, Chia-Chun Liu, Yi-Chun Chen, Yu-Ping Hsiao et autres

Caregiver stress is a global health issue, particularly acute in Taiwan due to demographic and cultural factors. While mindfulness meditation is effective for burnout, research on culturally adapted, digitally delivered interventions for Taiwanese caregivers is lacking. This study aimed to evaluate the …

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Current status and challenges of artificial intelligence application in managing Children’s emotions and attention

Yi-Ling Fan, Ying-Ying Tsai, Ching‐Han Hsu, Hui-Ju Chen et autres

Machine learning (ML), a core component of artificial intelligence (AI), is increasingly being used to assess children's emotions and attention, with potential applications in developmental monitoring and early identification of neurodevelopmental conditions such as autism spectrum disorder (ASD) and attention deficit hyperactivity …

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Public-oriented personalized long-term care service recommendation using machine learning

Shuo-Chen Chien, Yu-Hung Chang, Chia-Ming Yen, Ying‐Erh Chen et autres

Background Long-term care prediction models often rely on large multidomain assessments, which can limit interpretability and reuse across multiple service outcomes. Objective To determine whether a common reduced predictor set could support prediction of 20 later recorded long-term care service-use outcomes while …

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Clinical efficacy and safety of allogeneic adipose-derived stem cells ELIXCYTE in chronic kidney disease: a phase I/II study

Yi‐Cheng Lin, Yi-Pei Hung, Ya-Chung Tian, Ming-Ju Wu et autres

Chronic kidney disease (CKD) poses a significant global health burden by reducing quality of life and increasing mortality. Current therapies remain inadequate in halting its progression, necessitating novel treatments to improve outcomes. Adipose-derived stem cells (ADSCs) have emerged as a promising therapeutic …

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Automatic Classification of Toddler Gross Motor Development Based on Gait Feature Analysis

Jia-An Tsai, Tun‐Wen Pai, Hui-Ju Chen, Mary Ko et autres

Current diagnoses of developmental delays in toddlers often rely on clinical observations, and the processes are time-consuming and easy to be biased by subjective interpretation. These limitations possess particular challenges in resource-limited or rural areas where pediatric specialists are limited. This study …

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Impact of ALDH2 genotypes and alcohol consumption on age at first‐ever ischemic stroke: A cohort study in Taiwan

Yueh‐Feng Sung, Jiunn‐Tay Lee, Chaur‐Jong Hu, Jiann‐Shing Jeng et autres

BACKGROUND: The ALDH2*2 allele, common in East Asians, impairs aldehyde metabolism and leads to acetaldehyde accumulation during alcohol consumption. Whether this variant interacts with alcohol use to influence the age at ischemic stroke onset remains unclear. We evaluated the associations between ALDH2*2 …

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Real‐World Data as External Control in Assessing the Efficacy of Allogeneic Adipose‐Derived Stem Cells Therapy for Advanced Chronic Kidney Disease

Yi‐Chun Lin, Yi‐Pei Hung, Ya‐Chung Tian, Ming‐Ju Wu et autres

Chronic kidney disease is a progressive condition with limited therapeutic options in its advanced stages. Adipose-derived stem cell therapy has shown potential in preclinical studies for renal repair. This study evaluated the short-term stability of renal function in patients with moderate to …

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Exogeneous arsenic exposure estimation from urinary arsenic species measurements and prenatal exposure threshold for asthma in children

Chu‐Chih Chen, Yin-Han Wang, Chien Wen Sun, Huei‐Ju Liu et autres

Exposure to inorganic arsenic (iAs, arsenite As 3+ and arsenate As 5+ ) is associated with many adverse health effects, such as skin lesions, cancer, and developmental and neurotoxicity. Using urinary measurement of iAs as an exposure metric may not be precise, …

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