Dipankor Chatterjee

Abstract 63: Intratumoral Candida albicans associates with hypoxia and poor outcomes in non small cell lung cancer (NSCLC).

Dipankor Chatterjee, Dennis J. Grencewicz, Alexander Loncar, Ruohan Wu et autres

Abstract Resistance to radiation, chemotherapy, and immunotherapy remains a major challenge in non-small cell lung cancer (NSCLC), and emerging evidence suggests tumor-resident microbes may influence therapeutic response. To address this, we combined patient-level modeling with mechanistic studies in preclinical models. We first …

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ShinyEvents: harmonizing longitudinal data for real-world survival estimation

Alyssa Obermayer, Joshua Davis, Divya Priyanka Talada, Mingxiang Teng et autres

Longitudinal data analysis of the patient's treatment course is critical to uncovering variables that influence outcomes. However, existing tools have significant limitations in integrating multilayered time-series data, particularly in linking treatment events with survival outcomes. Here, we developed ShinyEvents, a web-based framework …

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Single-Cell Analysis and Cancer Research: Implications for Diagnosis and Treatment

Partha Biswas, Md Abdur Rahim, Dipankor Chatterjee, M. Sanni Ali et autres

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Candida albicans infiltrates colon and rectal cancers causing therapeutic resistance and decreased survival

Dennis J. Grencewicz, Alexander Loncar, Sylvain Ferrandon, McKenzie Kreamer et autres

Abstract The microbiome is increasingly recognized as a modifier of cancer progression and therapy response, yet the role of intratumoral fungi remains poorly defined. Here, we identify Candida albicans colonization within human colorectal tumors as a predictor of reduced survival and impaired …

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Delineating the mechanistic relevance of the TP53 gene and its mutational impact on gene expression and patients’ survival in bladder cancer

Dipankor Chatterjee, Shabiha Afroj Heeamoni, Tamanna Sultana, Sadia Islam Mou et autres

Bladder carcinoma (BLCA) is a widespread urological malignancy causing significant global mortality, often hindered by delayed diagnosis and limited treatments. BLCA frequently exhibits TP53 mutations, playing a pivotal role in its pathogenesis and underscoring the potential of targeting TP53 as a therapeutic …

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Computational exploration of SLC14A1 genetic variants through structure modeling, protein-ligand docking, and molecular dynamics simulation

Tamanna Sultana, Sadia Islam Mou, Dipankor Chatterjee, Md. Omar Faruk et autres

The urea transporter UT-B1, encoded by the SLC14A1 gene, has been hypothesized to be a significant protein whose deficiency and dysfunction contribute to the pathogenesis of bladder cancer and many other diseases. Several studies reported the association of genetic alterations in the …

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Identification and validation of prognostic signature genes of bladder cancer by integrating methylation and transcriptomic analysis

Dipankor Chatterjee, Sadia Islam Mou, Tamanna Sultana, Md. Ismail Hosen et autres

Being a frequent malignant tumor of the genitourinary system, Bladder Urothelial Carcinoma (BLCA) has a poor prognosis. This study focused on identifying and validating prognostic biomarkers utilizing methylation, transcriptomics, and clinical data from The Cancer Genome Atlas Bladder Urothelial Carcinoma (TCGA BLCA) …

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Comprehensive characterization of coding and non-coding single nucleotide polymorphisms of the Myoneurin (MYNN) gene using molecular dynamics simulation and docking approaches

Sadia Islam Mou, Tamanna Sultana, Dipankor Chatterjee, Md. Omar Faruk et autres

Genome-wide association studies (GWAS) identified a coding single nucleotide polymorphism, MYNN rs10936599, at chromosome 3q. MYNN gene encodes myoneurin protein, which has been associated with several cancer pathogenesis and disease development processes. However, there needed to be a more detailed characterization of …

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Role of Regulatory Immune Cells in Tumour Microenvironment (TME)

Mohammad Umer Sharif Shohan, Dipankor Chatterjee, Tasmiha Amin Oishy, Mohammad Kawsar Sharif Siam

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Meta-analysis of microarray and RNAseq data reveal OsbZIP52 to mediate salt stress responses in sensitive, tolerant and halophyte rice varieties

Dipankor Chatterjee, Mohammad Umer Sharif Shohan, Nishat Tamanna, Zeba I. Seraj

Abstract The development of salt-tolerant rice has become urgent due to climate change and rising global rice consumption. A large-scale analysis using different but related platforms has become imperative to filter out candidate genes responsible for salinity tolerance and salinity stress-responsive pathways. …

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A multi-epitope based vaccine against the surface proteins expressed in cyst and trophozoite stages of parasite Entamoeba histolytica

Dipankor Chatterjee, Razoan Al Rimon, Umar Faruq Chowdhury, Mohammad Riazul Islam

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Transcriptomic analysis of esophageal cancer reveals hub genes and networks involved in cancer progression

Dipankor Chatterjee, Md. Mostafijur Rahman, Anik Saha, Mohammad Kawsar Sharif Siam et autres

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