Lejian He

BCOR Mutations Identify a Clinically Aggressive Subset of Pediatric Rhabdomyosarcoma

Lianyuan Yu, Lejian He, Nan Zhang

Background: BCOR mutations occur in about 5% in pediatric rhabdomyosarcoma (RMS), their clinical significance and mechanistic roles remain undefined. This study characterizes BCOR-mutant RMS as a molecularly distinct, high-risk subgroup. Methods: Multimodal analysis of four pediatric embryonal RMS cases with BCOR mutations, …

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[Clinical and pathological characteristics of pediatric tumors with DICER1 mutations detected by Sanger sequencing].

Mingli Zhang, Xingfeng Yao, Ning Zhang, Congwei Jia et autres

DICER1 mutations are frequently detected in pediatric PPB, CN, SCST, ASK, nodular thyroid goiter, thyroid adenoma, and genitourinary rhabdomyosarcoma, which often represent as the index case of DICER1 syndrome. Performing DICER1 mutation testing in these patients not only facilitates tumor diagnosis and …

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[Opportunities and challenges in the pathological diagnosis of pediatric tumors in the molecular and artificial intelligence era].

Ying Fang, Lejian He, Ling Chen

Pediatric tumors differ significantly from adult cancers, possessing unique developmental origins, histological features, and molecular genetic changes. With the rapid advancement of multi-omics technologies, such as genomics, transcriptomics, proteomics, and epigenetic analyses, the molecular characteristics of pediatric tumors have been extensively revealed, …

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Ewing’s sarcoma family of tumors in adolescents in Beijing 2010–2019: a multicenter retrospective cohort study

Wen Zhao, Zhen Huang, Weiling Zhang, Qing Sun et autres

Background: Ewing's sarcoma family of tumors (ESFTs) comprises a group of aggressive malignancies predominantly affecting children and adolescents. This study aimed to evaluate the clinical characteristics, treatment outcomes, and prognostic factors in adolescent patients with ESFTs. Methods: A multicenter, retrospective cohort study …

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Comparative evaluation of bovine versus porcine bone xenografts in maxillary sinus floor augmentation: a systematic review and meta-analysis

Haibo Shi, Z Li, Junwu Su, Lejian He et autres

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[Interpretation of the soft tissue specific tumors in the 5th WHO classification of pediatric tumors].

Shudong Zhang, Lejian He, Lin Chen

The latest published WHO Classification of Pediatric Tumors is the first to be independent of the WHO Classification of Tumors in adults, serving as an independent volume that covers the latest advances in clinical characteristics, histopathology, molecular pathology, pathogenesis, and treatment of …

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[Detection of MYOD1-mutation of rhabdomyosarcoma and its clinicopathological characteristics].

Mingli Zhang, Xingfeng Yao, Ning Zhang, Jianfeng Xu et autres

The study has established a new method for accurate and rapid detection of MYOD1 mutation in rhabdomyosarcoma, particularly suitable for the formalin-fixed and paraffin-embedded samples in clinical settings. MYOD1 mutations more likely occur in spindle cell/sclerosing rhabdomyosarcoma of the head and neck …

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Novel polysaccharide-based fluorescent polymer drug delivery systems with natural extracts for squamous cell carcinoma treatment

Jun Wu, Kun Yang, Jinfan Zhou, Lejian He et autres

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A Network Information-Based Behavior Change Wheel for Populations at High Risk of Developing Gastric Cancer

Lejian He, Fen Xie, Dandan Wang, Lu Jiang et autres

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High CCR6 expression increases the risk of pediatric Langerhans cell histiocytosis

Xingfeng Yao, Yutian Zheng, Meng Zhang, Wentao Zheng et autres

Langerhans cell histiocytosis (LCH) is a rare disorder that primarily affects children. Considering the intricate clinical presentation of this disease, the identification of specific biomarkers associated with susceptibility to LCH is essential for timely diagnosis and risk stratification. In this study, we …

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A0772 – Locoregional therapy for adrenal gland metastases: A multi-institutional retrospective cohort comparative study

Xiaoqing Lin, Xiaobo Chen, Lin Zhong, Shuangshuang He et autres

[The pathology of pediatric in China over the past ten years: retrospect and prospect].

Ning Zhang, Lejian He

In the past decade, governments, including the national, provincial, municipal, and others, have increased their investment in children's health. Pathologists, especially pediatric pathologists, have greatly promoted the development and progress of pediatric pathology in China with the guidance of molecular pathological technology. …

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