Xiaona Jing

Delivery of siRNA Complexed with Palmitoylated α-Peptide/β-Peptoid Cell-Penetrating Peptidomimetics: Membrane Interaction and Structural Characterization of a Lipid-Based Nanocarrier System

Xiaona Jing, Camilla Foged, Birte Martin-Bertelsen, Anan Yaghmur et autres

Proteolytically stable α-peptide/β-peptoid peptidomimetics constitute promising cell-penetrating carrier candidates exhibiting superior cellular uptake as compared to commonly used cell-penetrating peptides (CPPs). The aim of the present study was to explore the potential of these peptidomimetics for delivery of small interfering RNA (siRNA) …

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Membrane adsorption and binding, cellular uptake and cytotoxicity of cell-penetrating peptidomimetics with α-peptide/β-peptoid backbone: Effects of hydrogen bonding and α-chirality in the β-peptoid residues

Xiaona Jing, Mingjun Yang, Marina R. Kasimova, Martin Malmsten et autres

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Interaction of Peptidomimetics with Bilayer Membranes: Biophysical Characterization and Cellular Uptake

Xiaona Jing, Marina R. Kasimova, Anders Simonsen, Lene Jørgensen et autres

Enzymatically stable cell-penetrating α-peptide/β-peptoid peptidomimetics constitute promising drug delivery vehicles for the transport of therapeutic biomacromolecules across membrane barriers. The aim of the present study was to elucidate the mechanism of peptidomimetic-lipid bilayer interactions. A series of peptidomimetics consisting of alternating cationic …

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Microcalorimetric and spectroscopic studies on the mechanism of interaction between novel peptoids and lipid bilayers - effect of length, charge and N-terminal end group

Xiaona Jing, Anders Simonsen, Marina R. Kasimova, Henrik Franzyk et autres

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Cell‐Penetrating Peptides for Cytosolic Delivery of Biomacromolecules

Camilla Foged, Xiaona Jing, Hanne Mørck Nielsen

This chapter contains sections titled: Introduction Internalization Mechanisms and Intracellular Trafficking Design of Cell - Penetrating Peptides for Intracellular Cargo Delivery Methodologies Side Effects Conclusion List of Abbreviations References

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