Giovanni Lai

Spatial memory tasks in aged animals: Overcoming methodological challenges

Lisa Bevilacqua, Giovanni Lai, Belinda Giorgetti, Davide Perini et autres

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The potential of marine-derived compounds in geroscience

Maria Elisa Giuliani, Chiara Giordani, Gianmarco Bertoni, Emanuele Francini et autres

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A Comparative Analysis of Grip Strength Evaluation Methods in a Large Cohort of Aged Mice

Giorgia Bigossi, Serena Marcozzi, Maria Elisa Giuliani, Giovanni Lai et autres

BACKGROUND: Grip strength is a key functional marker of musculoskeletal aging, widely used to assess sarcopenia. In preclinical research, multiple measurement methods are often combined to enhance reliability, but standardization remains challenging. To improve measurement robustness, we previously developed a composite strength …

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The aging choroid plexus and its relationship with gut dysbiosis and Klotho decline: possible intervention strategies

Giovanni Lai, Lisa Bevilacqua, Maria Elisa Giuliani, Giorgia Bigossi et autres

The choroid plexus (ChP) is a complex ventricular structure that forms a semi-permeable barrier between the blood and cerebrospinal fluid (CSF). It is responsible for CSF secretion and clearance, contains macrophages, and is one of the few sites within the central nervous …

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Additional Cover

Sandra Atlante, Luca Cis, Davide Pirolli, Michela Gottardi Zamperla et autres

Cover legend: The cover image is based on the article A Xanthine Derivative With Novel Heat Shock Protein 90-Alpha Inhibitory and Senolytic Properties by Sandra Atlante et al., https://doi.org/10.1111/acel.70047.

A Novel Cognitive Frailty Index for Geriatric Mice

Serena Marcozzi, Giorgia Bigossi, Maria Elisa Giuliani, Giovanni Lai et autres

Loss of cognitive function is a significant challenge in aging, and developing models to understand and target cognitive decline is crucial for the development of Geroscience-based interventions. Aged mice offer a valuable model as they share features of cognitive decline with humans. …

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A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties

Sandra Atlante, Luca Cis, Davide Pirolli, Michela Gottardi Zamperla et autres

The accumulation of senescent cells contributes to aging and related diseases; therefore, discovering safe senolytic agents-compounds that selectively eliminate senescent cells-is a critical priority. Heat shock protein 90 (HSP90) inhibitors (HSP90i), traditionally investigated for cancer treatment, have shown potential as senolytic agents. …

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Late-onset major depressive disorder: exploring the therapeutic potential of enhancing cerebral brain-derived neurotrophic factor expression through targeted microRNA delivery

Giovanni Lai, Marco Malavolta, Serena Marcozzi, Giorgia Bigossi et autres

Major depressive disorder (MDD) is a severe psychiatric condition that significantly impacts the overall quality of life. Although MDD can occur across all age groups, it is notably prevalent among older individuals, with the aggravating circumstance that the clinical condition is frequently …

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Marine Compounds and Age-Related Diseases: The Path from Pre-Clinical Research to Approved Drugs for the Treatment of Cardiovascular Diseases and Diabetes

Maria Elisa Giuliani, Giorgia Bigossi, Giovanni Lai, Serena Marcozzi et autres

Ageing represents a main risk factor for several pathologies. Among them, cardiovascular diseases (CVD) and type 2 diabetes mellitus (T2DM) are predominant in the elderly population and often require prolonged use of multiple drugs due to their chronic nature and the high …

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Spreading Senescent Cells’ Burden and Emerging Therapeutic Targets for Frailty

Serena Marcozzi, Giorgia Bigossi, Maria Elisa Giuliani, Giovanni Lai et autres

The spreading of senescent cells' burden holds profound implications for frailty, prompting the exploration of novel therapeutic targets. In this perspective review, we delve into the intricate mechanisms underlying senescent cell spreading, its implications for frailty, and its therapeutic development. We have …

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C60 in olive oil causes light-dependent toxicity and does not extend lifespan in mice

Kristopher J. Grohn, Brandon S. Moyer, Danique C. Wortel, Cheyanne M. Fisher et autres

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