A Novel Cognitive Frailty Index for Geriatric Mice
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Le résumé fourni par la source
Loss of cognitive function is a significant challenge in aging, and developing models to understand and target cognitive decline is crucial for the development of Geroscience-based interventions. Aged mice offer a valuable model as they share features of cognitive decline with humans. Despite numerous studies, knowledge of longitudinal age-related cognitive changes and cognitive frailty in naturally aging mice is limited, particularly in cohorts exceeding 30 months of age, where cognitive decline is more pronounced. Moreover, the impaired physical function of aged mice is known to affect latency-based strategies to measure cognitive performances. Here, we show a comprehensive longitudinal assessment using the Barnes Maze test in a large cohort of 424 aged (≥ 21 months) C57BL/6J mice. We introduced a new metric, the Cognitive Frailty Index (CoFI), which summarizes different age-associated Barnes Maze parameters into a unique function. CoFI strongly associates with advancing age and mortality, offering a reliable ability to discriminate long- and short-lived mice. We also established a CoFI cut-off and a physically adjusted CoFI, both of which can distinguish between physical and cognitive frailty. This is further supported by the enhanced predictive power when physical and cognitive frailty are combined to assess short-term mortality. Moreover, the computation method for CoFI is adaptable to various cognitive assessment tests, leveraging procedures akin to those used for calculating other frailty indices. In conclusion, through robust longitudinal tracking, CoFI has the potential to become an important ally in assessing the effectiveness of Geroscience-based interventions to counteract age-related cognitive impairment.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- A Novel Cognitive Frailty Index for Geriatric Mice
- Date Crossref
- 21/05/2025
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Istituto Nazionale di Riposo e Cura per Anziani pays non établi dans la noticeÉtablissement de santé
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Istituti di Ricovero e Cura a Carattere Scientifico pays non établi dans la noticeÉtablissement de santé
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Marche Polytechnic University pays non établi dans la noticeUniversité ou école supérieure
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University Medical Center Utrecht Division of Laboratories pays non établi dans la noticeÉtablissement de santé
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Hycult Biotech (Netherlands) pays non établi dans la noticeEntreprise
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IFOM pays non établi dans la noticeStructure de recherche
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Istituto di Genetica Molecolare pays non établi dans la noticeStructure de recherche
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Advanced Technology Center for Aging Research and Geriatric Mouse Clinic IRCCS INRCA Ancona Italy pays non établi dans la noticeÉtablissement de santé
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Advanced Technology Center for Aging Research IRCCS INRCA Ancona Italy pays non établi dans la noticeInstitution
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Center for Neurobiology of Aging IRCCS INRCA Ancona Italy pays non établi dans la noticeInstitution
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Experimental Animal Models for Aging Unit Scientific Technological Area pays non établi dans la noticeInstitution
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Charles River Laboratories Calco Italy pays non établi dans la noticeInstitution
Istituto Nazionale di Riposo e Cura per Anziani, Istituti di Ricovero e Cura a Carattere Scientifico et Marche Polytechnic University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.