Alain Kfoury

A Gender-Dependent Molecular Switch of Inflammation via MyD88/Estrogen Receptor-Alpha Interaction

Rana El Sabeh, Mélanie Bonnet, Katy Le Corf, Kevin A. Lang et autres

INTRODUCTION: Most Toll-like receptors and IL-1/IL-18 receptors activate a signaling cascade via the adaptor molecule MyD88, resulting in NF-κB activation and inflammatory cytokine and chemokine production. Females are less susceptible than males to inflammatory conditions, presumably due to protection by estrogen. The …

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Reference values and sex differences in absolute and relative kidney size. A Swiss autopsy study

Sabrina Addidou Kalucki, Christelle Lardi, Jonas Garessus, Alain Kfoury et autres

BACKGROUND: Men have larger kidneys than women, but it is unclear whether gender remains an independent predictor of kidney size (expressed as weight or length) after correction for body size. We analysed autopsy data to assess whether relative renal length and weight …

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Corrigendum to “Toll-like receptor 3 downregulation is an escape mechanism from apoptosis during hepatocarcinogenesis” [J Hepatol 71 (2019) 763–772]

Marc Bonnin, Nadim Farés, Barbara Testoni, Yann Estornes et autres

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Toll-like receptor 3 downregulation is an escape mechanism from apoptosis during hepatocarcinogenesis

Marc Bonnin, Nadim Farés, Barbara Testoni, Yann Estornes et autres

BACKGROUND & AIMS: Low levels of toll-like receptor 3 (TLR3) in patients with hepatocellular carcinoma (HCC) are associated with poor prognosis, primarily owing to the loss of inflammatory signaling and subsequent lack of immune cell recruitment to the liver. Herein, we explore …

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FP086IS RELATIVE KIDNEY MASS LARGER IN WOMEN? A SWISS AUTOPSY STUDY

Addidou-Kalucki Sabrina, Christelle Lardi, Alain Kfoury, Burnier Michel et autres

INTRODUCTION: Epidemiological studies suggest that women are less prone to the development of hypertension than men and progress less rapidly to end stage renal disease. Whether this is linked to differences in renal size/mass and thus glomeruli number remains unclear, as imaging …

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AMPK promotes survival of c‐Myc‐positive melanoma cells by suppressing oxidative stress

Alain Kfoury, Marzia Armaro, Jessica Sordet‐Dessimoz, Maria Pilar Giner et autres

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A Gender-Dependent Molecular Switch of Inflammation via MyD88/Estrogen Receptor-alpha Interaction

Rana El Sabeh, Mélanie Bonnet, Katy Le Corf, Kevin A. Lang et autres

Abstract Most Toll-like receptors and IL-1/IL-18 receptors activate a signaling cascade via the adaptor molecule MyD88, resulting in NF-κB activation and inflammatory cytokine and chemokine production. Females are less susceptible than males to inflammatory conditions, presumably due to protection by estrogen. Here …

fr, lb (code pays fourni par la source)

Dual function of MyD88 in inflammation and oncogenesis

Alain Kfoury, François Virard, Toufic Renno, Isabelle Coste

PURPOSE OF REVIEW: Inflammation is emerging as a new hallmark of cancer, and the toll-like receptor and interleukin-1 receptor adaptor molecule MyD88 has been linked to tumorigenesis. The purpose of this review is to give a brief overview of the latest advances …

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MyD88 in DNA Repair and Cancer Cell Resistance to Genotoxic Drugs

Alain Kfoury, Katy Le Corf, Rana El Sabeh, Alexandra Journeaux et autres

BACKGROUND: MyD88 is an adaptor molecule in Toll-like receptor and interleukin 1 receptor signaling implicated in tumorigenesis through proinflammatory mechanisms. We have recently reported that MyD88 also directly promotes optimal activation of the Ras/Erk pathway. Here we investigate MyD88 implication in the …

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p58IPK-Mediated Attenuation of the Proapoptotic PERK-CHOP Pathway Allows Malignant Progression upon Low Glucose

Anne‐Laure Huber, Justine Lebeau, P. Guillaumot, Virginie Pétrilli et autres

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LAMTOR1 depletion induces p53-dependent apoptosis via aberrant lysosomal activation

Mouhannad Malek, P. Guillaumot, Justine Lebeau, Virginie Pétrilli et autres

Lysosomal regulation is a poorly understood mechanism that is central to degradation and recycling processes. Here we report that LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and mTOR activator 1) downregulation affects lysosomal activation, through mechanisms that are not solely due to mTORC1 inhibition. …

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Dual function of MyD88 in RAS signaling and inflammation, leading to mouse and human cell transformation

Isabelle Coste, Katy Le Corf, Alain Kfoury, Isabelle Hmitou et autres

Accumulating evidence points to inflammation as a promoter of carcinogenesis. MyD88 is an adaptor molecule in TLR and IL-1R signaling that was recently implicated in tumorigenesis through proinflammatory mechanisms. Here we have shown that MyD88 is also required in a cell-autonomous fashion …

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