Mélanie Bonnet

Targeting ERK-MYD88 interaction leads to ERK dysregulation and immunogenic cancer cell death

François Virard, Stéphane Giraud, Mélanie Bonnet, Léa Magadoux et autres

The quest for targeted therapies is critical in the battle against cancer. The RAS/MAP kinase pathway is frequently implicated in neoplasia, with ERK playing a crucial role as the most distal kinase in the RAS signaling cascade. Our previous research demonstrated that …

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A Gender-Dependent Molecular Switch of Inflammation via MyD88/Estrogen Receptor-Alpha Interaction

Rana El Sabeh, Mélanie Bonnet, Katy Le Corf, Kevin A. Lang et autres

INTRODUCTION: Most Toll-like receptors and IL-1/IL-18 receptors activate a signaling cascade via the adaptor molecule MyD88, resulting in NF-κB activation and inflammatory cytokine and chemokine production. Females are less susceptible than males to inflammatory conditions, presumably due to protection by estrogen. The …

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Fit αβ T-cell receptor suppresses leukemogenesis of Pten-deficient thymocytes

Stéphanie Gon, Marie Loosveld, Thomas Crouzet, Delphine Potier et autres

Signaling through the αβT cell receptor (TCR) is a crucial determinant of T-cell fate and can induce two opposite outcomes during thymocyte development: cell death or survival and differentiation. To date, the role played by T-cell receptor in the oncogenic transformation of …

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A Gender-Dependent Molecular Switch of Inflammation via MyD88/Estrogen Receptor-alpha Interaction

Rana El Sabeh, Mélanie Bonnet, Katy Le Corf, Kevin A. Lang et autres

Abstract Most Toll-like receptors and IL-1/IL-18 receptors activate a signaling cascade via the adaptor molecule MyD88, resulting in NF-κB activation and inflammatory cytokine and chemokine production. Females are less susceptible than males to inflammatory conditions, presumably due to protection by estrogen. Here …

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MYC fails to efficiently shape malignant transformation in T‐cell acute lymphoblastic leukemia

Marie Loosveld, Mélanie Bonnet, Stéphanie Gon, Bertrand Montpellier et autres

MYC is a potent oncogene involved in ∼70% of human cancers, inducing tumorigenesis with high penetrance and short latency in experimental transgenic models. Accordingly, MYC is recognized as a major driver of T-cell acute lymphoblastic leukemia (T-ALL) in human and zebrafish/mouse models, …

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IgM+IgD+CD27+ B cells are markedly reduced in IRAK-4–, MyD88-, and TIRAP- but not UNC-93B–deficient patients

Sandra Weller, Mélanie Bonnet, Héloïse Delagrèverie, Laura Israël et autres

We studied the distribution of peripheral B-cell subsets in patients deficient for key factors of the TLR-signaling pathways (MyD88, TIRAP/MAL, IL-1 receptor-associated kinase 4 [IRAK-4], TLR3, UNC-93B, TRIF). All TLRs, except TLR3, which signals through the TRIF adaptor, require MyD88 and IRAK-4 …

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Dérégulation de MYC dans les Leucémies Aiguës Lymphoblastiques T

Mélanie Bonnet

La leucémie aiguë lymphoblastique (LAL-T) est une hémopathie maligne qui représente 10 à 15% des LAL pédiatriques et 25% des LAL de l’adulte. Bien que la prise en charge et le pronostic (rémission dans 80-85% des cas) des LAL se soient améliorés …

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Dérégulation de MYC dans les Leucémies Aiguës Lymphoblastiques T

Mélanie Bonnet

La leucémie aiguë lymphoblastique (LAL-T) est une hémopathie maligne qui représente 10 à 15% des LAL pédiatriques et 25% des LAL de l’adulte. Bien que la prise en charge et le pronostic (rémission dans 80-85% des cas) des LAL se soient améliorés …

Posttranscriptional deregulation of MYC via PTEN constitutes a major alternative pathway of MYC activation in T-cell acute lymphoblastic leukemia

Mélanie Bonnet, Marie Loosveld, Bertrand Montpellier, Jean‐Marc Navarro et autres

Cumulative evidence indicates that MYC, one of the major downstream effectors of NOTCH1, is a critical component of T-cell acute lymphoblastic leukemia (T-ALL) oncogenesis and a potential candidate for targeted therapy. However, MYC is a complex oncogene, involving both fine protein dosage …

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Post-Transcriptional Deregulation of MYC Via PTEN Constitutes a Major Alternative Pathway of MYC Activation In T-Cell Acute Lymphoblastic Leukemia

Mélanie Bonnet, Marie Loosveld, Bertrand Montpellier, Jean‐Marc Navarro et autres

Abstract Abstract 4188 Cumulative evidence indicates that MYC, one of the major downstream effectors of NOTCH1, is a critical component of T-cell acute lymphoblastic leukemia (T-ALL) oncogenesis and a potential candidate for targeted therapy. However, MYC is a complex oncogene, involving both …

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