Vagan Bokhian

Retrospective analysis of BUCEN score prognostic value in Russian population of patients with advanced adrenocortical carcinoma treated with platinum-based chemotherapy in combination with mitotane

Yaroslav A. Zhulikov, Елена Владимировна Артамонова, A. Yu. Kolycheva, Elena Igorevna Kovalenko et autres

Introduction. Currently, the algorithm for selecting first-line treatment for advanced adrenocortical carcinoma (ACC) is not clearly defined; the choice between mitotane monotherapy and its combination with platinum-based chemotherapy remains controversial. In a large retrospective study (n = 439), the BUCEN scoring system …

ru, us (code pays fourni par la source)

Surgical treatment of pheochromocytoma complicated by tumor thrombosis of the inferior vena cava: a post-hoc analysis and series of clinical cases

Maryam R. Tamrazova, Vagan Bokhian, M. M. Gabrava, Yaroslav A. Zhulikov et autres

Aim. To describe the surgical approach and evaluate the results of treatment in a series of cases of pheochromocytoma complicated by tumor thrombosis of the inferior vena cava (IVC). Materials and methods. The study presents the experience with surgical treatment of patients …

id, ru (code pays fourni par la source)

The role of somatostatin analogues in the adjuvant treatment of NETs of the stomach CT1–2N0M0, GRADE I–II, 1st clinical and morphological type: results of a single-center retrospective study

Ivan N. Peregorodiev, E. A. Mustafazade, Ol’ga Aleksandrovna Malikhova, A. O. Bogdanova et autres

Background: Gastric type 1 neuroendocrine neoplasms (gNENs) are relatively indolent malignancies with low metastatic potential. Endoscopic resection (ER) is considered the primary treatment, while somatostatin analogs (SSAs) have proven anti-secretory and anti-proliferative effects. However, routine adjuvant SSA therapy after ER is not …

ru (code pays fourni par la source)

Retrospective Analysis of the Effectiveness of Somatostatin Analogs in the Treatment of Metastatic Pheochromocytoma/Paraganglioma. A Clinical Case on the efficacy of long-acting release octreotide

Yaroslav A. Zhulikov, Elena Igorevna Kovalenko, K. N. Galanova, A. N. Tyatyushkina et autres

Introduction. Pheochromocytoma (PC) and paraganglioma (PG) are neuroendocrine neoplasms and are characterized by a high frequency of somatostatin receptor (SSTR) expression. The efficacy of somatostatin analogues in PC/PG remains poorly studied, despite the lack of evidence base, these drugs are included in …

ru (code pays fourni par la source)

Efficacy of chemotherapy and targeted therapy for metastatic pheochromocytoma / paraganglioma: retrospective analysis

Yaroslav A. Zhulikov, Elena Igorevna Kovalenko, K. N. Galanova, A. N. Tyatyushkina et autres

Introduction: Pheochromocytoma (PC) and paraganglioma (PG) are rare neuroendocrine tumors derived from adrenal chromaffin cells. The main options of systemic therapy for PC / PG are alkylating agent-based chemotherapy (ChT) and targeted therapy with sunitinib. There are no comparative data on the …

ru (code pays fourni par la source)

Efficiency of platinum-based chemotherapy re-induction for adrenocortical cancer treatment

Zhulikov Ya., Ekaterina Аndreevna Kovalenko, Vagan Bokhian, E. A. Evdokimova et autres

The combination of platinum-based chemotherapy with mitotane (m) is the standard first-line therapy for metastatic adrenocortical cancer (ACC) with long-term disease control in approximately 25% of patients.Considering the lack of effective regimens for second and subsequent lines of therapy, it seems relevant …

ru (code pays fourni par la source)

Specific characteristics of metabolomics as assessed by gas chromatography-mass spectrometry in patients with adrenocortical cancer and with adrenal incidentalomas in congenital adrenal hyperplasia

Zulfiya R. Shafigullina, Л. И. Великанова, Наталья Владимировна Ворохобина, Ekaterina V. Malevanaya et autres

Background: Prolonged episodes of uncontrolled congenital adrenal hyperplasia (CAH) have been shown to result in the occurrence of secondary adrenal neoplasms. Prevalence of adrenal incidentalomas in the patients with 21-hydroxylase deficiency ranges from 11% to 82%. As assessed by gas chromatography-mass spectrometry …

ru, us (code pays fourni par la source)

Сurrent options and perspectives of systemic therapy for advanced or metastatic adrenocortical cancer

Ya. А. Zhulikov, Elena Igorevna Kovalenko, Vagan Bokhian, Елена Владимировна Артамонова

Adrenocortical cancer is an orphan tumor with poor prognosis. The combination of EDP chemotherapy regimen and mitotane is the standard for the first‑line therapy. But there are no effective options for the second and consequent lines of therapy. The standard of second‑line …

ru (code pays fourni par la source)

Modern view on the classification of neuroendocrine neoplasms of stomach

Ivan N. Peregorodiev, Vagan Bokhian, Vera V. Delektorskaya, A. B. Safonova

Neuroendocrine neoplasms (NEN) of the stomach include a heterogeneous group of neoplasms characterized by different pathogenetic mechanisms, metastatic potential, and prognosis. The incidence of gastric NAN has increased 15-fold over the past few decades. It is necessary to clearly distinguish between well-differentiated …

Study of urine steroid profiles by gas chromatography-mass spectrometry in patients with adrenocortical cancer in the course of treatment

Л. И. Великанова, Наталья Владимировна Ворохобина, Zulfiya R. Shafigullina, Vagan Bokhian et autres

Background: Adrenocortical carcinoma (ACC) is a rare and aggressive disease. There are only few studies evaluating the diagnostic value of gas chromatography-mass spectrometry (GC-MS) for detection of ACC recurrence after surgery. It is necessary to conduct an in-depth study to search for …

ru (code pays fourni par la source)

Intracardiac intravenous leiomyomatosis: description of a clinical case

Ivan Sokratovich Stilidi, Eduard R Charchyan, К. И. Жорданиа, Vagan Bokhian et autres

КЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ ХИРУРГИЯИнтракардиальный внутривенный лейомиоматоз -редкое заболевание, характеризующееся прежде всего наличием мезенхимальной опухоли в матке, которая по своим морфологическим признакам не противоречит лейомиоме, но обладает способностью прорастать в просветы вен.Распространяясь по внутренним подвздошным или яичниковым венам, она может достигать нижней полой …

ru (code pays fourni par la source)

Intracardiac intravenous leiomyomatosis: diagnosis and management

Ivan Sokratovich Stilidi, Julia Paianidi, Vagan Bokhian, Julia Andreeva et autres

ru, us (code pays fourni par la source)