К. И. Жорданиа

Comparison of Methods for Concentration Assessment of Extracellular Vesicles Isolated from Different Biological Fluids

Gleb O. Skryabin, Adel D. Enikeev, Anastasiya A. Beliaeva, К. И. Жорданиа et autres

Abstract Accurate quantification of extracellular vesicles (EVs) remains a significant challenge in biomedical research. Although various analytical methods have been developed, their reliability is often limited by the presence of non-vesicular nanoparticles and biological contaminants, particularly in biological fluids. Moreover, for some …

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Methylation of long non-coding rna genes: SNHG6, SNHG12, TINCR in ovarian cancer

Svetlana S. Lukina, Alexey M. Burdennyy, Е. А. Филиппова, Л. А. Урошлев et autres

Ovarian cancer (OC) develops asymptomatically and escapes diagnosis until advanced stages, the feature contributing to a higher mortality rate. New prospects of OC diagnosis and treatment have been opened in studies of the gene regulation mechanisms that involve long noncoding RNAs (lncRNAs) …

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Integrated miRNA Profiling of Extracellular Vesicles from Uterine Aspirates, Malignant Ascites and Primary-Cultured Ascites Cells for Ovarian Cancer Screening

Gleb O. Skryabin, Andrei V. Komelkov, К. И. Жорданиа, Dmitry V. Bagrov et autres

Extracellular vesicles (EVs) are of growing interest in the context of screening for highly informative cancer markers. We have previously shown that uterine aspirate EVs (UA EVs) are a promising source of ovarian cancer (OC) diagnostic markers. In this study, we first …

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Methylation of Long Noncoding RNA Genes SNHG6, SNHG12, and TINCR in Ovarian Cancer

Svetlana S. Lukina, Alexey M. Burdennyy, Е. А. Филиппова, Л. А. Урошлев et autres

Abstract Ovarian cancer (OC) develops asymptomatically and escapes diagnosis until advanced stages, the feature contributing to a higher mortality rate. New prospects of OC diagnosis and treatment have been opened in studies of the gene regulation mechanisms that involve long noncoding RNAs …

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Long Non-Coding RNAs and microRNAs Groups in the Regulation of Expression Level of a Number of Tumor-Associated Genes in Ovarian Cancer

Irina V. Pronina, Е. А. Филиппова, Olga Brovkina, Alexey M. Burdennyy et autres

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Comparison of Methods for MicroRNA Isolation from Extracellular Vesicles Obtained from Ascitic Fluids

Gleb O. Skryabin, Svetlana Vinokurova, Nadezhda V. Elkina, Daria A. Denisova et autres

Secreted extracellular vesicles (EVs) contain active biomolecules, including miRNAs, composition of which reflects epigenetic changes occurring in cells during pathological processes, in particular, malignant transformation. The accumulated pool of data on the role of EVs in carcinogenesis has stimulated investigations of the …

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The Role of Long Non-Coding RNA CCAT1 and SNHG14 in Activation of Some Protein-Coding Genes Associated with the Development of Ovarian Cancer

Olga Brovkina, Irina V. Pronina, Alexey M. Burdennyy, Л. А. Урошлев et autres

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Extracellular Vesicles from Uterine Aspirates Represent a Promising Source for Screening Markers of Gynecologic Cancers

Gleb O. Skryabin, Andrei V. Komelkov, К. И. Жорданиа, Dmitry V. Bagrov et autres

Extracellular vesicles (EVs), including exosomes, are key factors of intercellular communication, performing both local and distant transfers of bioactive molecules. The increasingly obvious role of EVs in carcinogenesis, similarity of molecular signatures with parental cells, precise selection and high stability of cargo …

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Long non-coding RNAs and microRNAs groups in the expression level regulation of a number of tumor-associated genes in ovarian cancer

I. V. Pronina, Elena A. Filippova, O. I. Brovkina, Alexey M. Burdennyy et autres

Genetic and epigenetic profiling of the BRCA1 / 2 genes in solitary ovarian cancer and multiple primary ovarian tumors

Meerim E. Esenova, Yu. G. Payanidi, Svetlana Vinokurova, Alexey S. Shevchuk et autres

Background. Ovarian cancer is a complex and poorly studied disease that kills nearly 70–80 % of patients. Therefore, practitioners are interested in any opportunity of improving survival of these patients. From this point of view, investigation of genetic and epigenetic functions associated …

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Characteristics of hematopoiesis in primary and recurrent ovarian cancer

С. В. Чулкова, Ajchurok M. Kozhonalieva, I. S. Stylidi, Irina Vladimirovna Poddubnaya et autres

Introduction. An important aspect of cancer treatment today is the concept of immuno-targeted therapy, which requires a deep understanding of the characteristics of immune reactions in the body of a cancer patient. Bone marrow is the central organ of immunopoiesis, therefore, along …

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Stromal cell ovarian tumors

Almaz Beyshembaev, К. И. Жорданиа, Tamara Zhekshenbek k.

This review represents the latest data about rare type of ovarian neoplasms - stromal cell tumors, which are 7-8% of all ovarian neoplasias. This group of diseases is characterized by an ambiguous prognosis and high recurrence rate. The paper presents a general …