Linfa Chen

A novel SLC20A2 variant associated with primary brain calcification: A case report

Linfa Chen, Juanli Liu, Shan Wei, Junbing He

A female patient in her late 50s was admitted with sudden-onset speech impairment. Brain computed tomography identified multiple intracranial calcifications alongside an acute ischemic lesion in the left frontoparietal region. Whole-genome sequencing revealed a novel frameshift variant in the SLC20A2 gene (c.1089del, …

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A functional polymorphism in ADAMTS7 3′-UTR abrogates miR-654-5p-mediated ADAMTS7 expression suppression and increases the incidence, short-term outcome, and recurrence of large artery atherosclerotic stroke among southern Chinese population

Linfa Chen, Shan Wei, Zishan Li, Yutian Zhang et autres

BACKGROUND: single-nucleotide polymorphism (SNP) rs1045130 and large artery atherosclerotic (LAA) stroke. MATERIALS AND METHODS: Genotyping analyses were conducted on two independent case-control cohorts comprising 1,027 LAA patients and 1,043 age-matched controls, followed by the quantification of ADAMTS7 expression and its downstream molecular …

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A functional polymorphism in ADAMTS7 3′-UTR abrogates miR-654-5p-mediated ADAMTS7 expression suppression and increases the incidence, short-term outcome, and recurrence of large artery atherosclerotic stroke among southern Chinese population

Linfa Chen, Shan Wei, Zishan Li, Yutian Zhang et autres

A Disintegrin and Metalloproteinase with Thrombospondin motifs 7 (ADAMTS7) plays a critical role in atherosclerosis by degrading the extracellular matrix and modulating smooth muscle cell (SMC) proliferation, migration, and phenotypic transformation. This study investigated the association between the ADAMTS7 single-nucleotide polymorphism (SNP) …

A functional polymorphism in ADAMTS7 3′-UTR abrogates miR-654-5p-mediated ADAMTS7 expression suppression and increases the incidence, short-term outcome, and recurrence of large artery atherosclerotic stroke among southern Chinese population

Linfa Chen, Shan Wei, Zishan Li, Yutian Zhang et autres

A Disintegrin and Metalloproteinase with Thrombospondin motifs 7 (ADAMTS7) plays a critical role in atherosclerosis by degrading the extracellular matrix and modulating smooth muscle cell (SMC) proliferation, migration, and phenotypic transformation. This study investigated the association between the ADAMTS7 single-nucleotide polymorphism (SNP) …

Hemodynamic disturbances in vertebral artery dominance: a potential pathogenic mechanism in acute isolated pontine infarction

Yanquan Yuan, Shan Wei, Shijie Xu, Jiaohao Li et autres

BACKGROUND: Isolated pontine infarction (IPI) is closely linked to the hemodynamic properties of the vertebral artery. However, the underlying pathogenic mechanisms remain insufficiently defined. This study was designed to explore the contribution of vertebral artery hemodynamic disturbances to the development of IPI …

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Endovascular Interventional Thrombolysis Combined With Mild Hypothermia Induced by Intravascular Hypothermia Saline Fails to Improve Outcomes in the Acute Large Vessel Occlusive Cerebral Infarction Patients: A Single‐Center Prospective Case‐Control Study

Li Jiang, Wei Zhang, Shaonian Tang, Linfa Chen et autres

BACKGROUND: The mild hypothermia for thrombolysis in patients with cerebral infarction caused by acute large-vessel occlusion is superior to the standard medical treatment. AIMS: The safety and effectiveness of cytoprotection and prognosis from the hypothermia is under investigation. METHODS: Twenty-five patients with …

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Association of MTMR3 rs12537 at miR-181a Binding Site with Ischemic Stroke in Southern Chinese Han Population

Linfa Chen, Shan Wei, Yutian Zhang, You Li et autres

Background: Single nucleotide polymorphisms (SNPs) at microRNA (miRNA)--binding sites influence the development of ischemic stroke (IS) by affecting the expression of specific target genes. Myotubularin-related protein 3 (MTMR3), which is involved in autophagy, is directly targeted by miR-181a. This research examined the …

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Association of GWAS-Reported Variant of Matrix Metalloproteinase 12 Gene with Susceptibility to Ischemic Stroke in Southern Chinese Population

Linfa Chen, Ke Liao, Yutian Zhang, Shutao Zheng et autres

Background: Accumulating evidence suggests that matrix metalloproteinase (MMP) 12 plays a detrimental role in cerebro-cardiovascular diseases, including ischemic stroke (IS). Previous genome-wide association studies (GWAS) correlated the MMP12 rs660599 variant to IS risk in Europeans. However, this association is yet to be …

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The challenge of managing ischemic stroke in brucellosis: a case report

Linfa Chen, Xiaolong Lin, Xiuqu Cai, Shiting Zeng et autres

A 64-year-old woman was admitted to the hospital for sudden weakness in one of her left limbs. The patient was diagnosed with acute ischemic stroke (IS) of undetermined cause and received intravenous thrombolysis. Following thrombolysis, the patient’s left limb weakness improved, but …

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Polymorphisms of Calgranulin Genes and Ischemic Stroke in a Chinese Population

Linfa Chen, Xinglan Chen, Yajun Wang, Shengnan Li et autres

Background: The S100/calgranulin gene appears to modulate neuroinflammation following cerebral ischemia and could be a valuable biomarker for stroke prognosis, according to growing research. This study aimed at evaluating the correlation between calgranulin gene variants and susceptibility to ischemic stroke (IS) in …

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Correlation Between Angiotensin Receptor Type 1 Polymorphisms and Atherosclerotic Cerebral Infarction Risk

Linfa Chen, Ying Wang, Yajun Wang, Shaoting Huang et autres

Background: Emerging evidences suggest that the angiotensin receptor type 1 (AT1R) contributes heavily to the pathogenesis of atherosclerotic cerebral infarction (ACI). Herein, we examined a potential link between AT1R gene polymorphisms and ACI risk among a Southern Han Chinese population. Methods: The …

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LncRNA GAS5 rs145204276 Polymorphism Reduces Renal Cell Carcinoma Susceptibility in Southern Chinese Population

Xiaoyao Xiang, Linfa Chen, Jiawen He, Guoda Ma et autres

Xiaoyao Xiang,1 Linfa Chen,2 Jiawen He,3 Guoda Ma,3,4 You Li3 1Department of Urology, The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, People’s Republic of China; 2Department of NeUrology, Huizhou Third People’s Hospital, Guangzhou Medical University, Huizhou, 516000, People’s Republic of …

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