Carole Almire

High frequency of CD95 + / CD45RA − regulatory T cells defines an immunosuppressive profile associated with MDS progression

Romain Vazquez, Nicolas Deredec, Ismaël Boussaid, Pierre Boncoeur et autres

Summary Dynamic interactions between mutated haematopoietic cells and immune cells are key drivers of myelodysplastic neoplasms (MDS) initiation and progression. Regulatory T cells (Tregs) are central mediators of immunosuppression in MDS. We thus aimed to characterize Treg subpopulations in the bone marrow …

fr, gb, be (code pays fourni par la source)

Development of Machine‐Assisted, Human‐Centred Bone Marrow Cell Classification: Feasibility Analysis in Patients With Myelodysplastic Syndromes

Kíyoyuki Ogata, Yuto Mochimaru, Leonie Saft, Gerrit Sijm et autres

Background: Cytomorphological examination and classification of bone marrow (BM) cells using a microscope is essential for diagnosing various diseases affecting the haematopoietic system. However, this requires expertise, is effort-intensive and is inherently subjective. Methods: We developed a method for automatically capturing BM …

us, se, nl, fr, jp (code pays fourni par la source)

Loss of hematopoietic progenitors heterogeneity is an adverse prognostic factor in lower-risk myelodysplastic neoplasms

Charles Dussiau, Thibault Comont, Camille Knosp, Inès Vergnolle et autres

Myelodysplastic neoplasms (MDS) are characterized by clonal evolution starting from the compartment of hematopoietic stem and progenitors cells (HSPCs), leading in some cases to leukemic transformation. We hypothesized that deciphering the diversity of the HSPCs compartment may allow for the early detection …

fr (code pays fourni par la source)

S162: LOSS OF HEMATOPOIETIC PROGENITORS HETEROGENEITY IS AN ADVERSE PROGNOSTIC FACTOR IN MYELODYSPLASTIC SYNDROMES

Charles Dussiau, Thibault Comont, Camille Knosp, Inès Vergnolle et autres

Background: Myelodysplastic syndromes (MDS) represent a heterogeneous group of bone marrow disorders characterized by clonal evolution starting from the HSPCs compartment that contains the cell of origin for MDS. Stratification of patients at diagnosis to evaluate the risk of leukemic transformation is …

fr (code pays fourni par la source)

Optical genome mapping refines cytogenetic diagnostics, prognostic stratification and provides new molecular insights in adult MDS/AML patients

Estelle Balducci, Sophie Kaltenbach, Patrick Villarèse, Eugénie Duroyon et autres

Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are clinically and genetically heterogeneous myeloid malignancies associated with a broad range of recurring mutations and cytogenetic abnormalities. To date, their diagnostic workup includes a conventional karyotype to establish the IPSS-R (Revised International Prognostic …

fr (code pays fourni par la source)

Venetoclax combination therapy induces deep AML remission with eradication of leukemic stem cells and remodeling of clonal haematopoiesis

Romain Vazquez, Claire Bréal, Loria Zalmaï, Chloé Friedrich et autres

Treatment of acute myeloid leukemia (AML) in older patients remains challenging 1 . Promising results recently emerged in patients treated with the BCL-2 inhibitor venetoclax associated with low dose cytarabine (LDAC) or hypomethylating agents (HMAs) 2 , 3 , 4 . This …

fr (code pays fourni par la source)

Réalisation, lecture et interprétation morphologique des adénogrammes et empreintes ganglionnaires

Germán Lobos, J.-F. Lesesve, Karim Maloum, N. Freynet et autres

La « cytologie ganglionnaire » recouvre l’observation au microscope optique des étalements de ponction (« adénogramme ») et des appositions de section (« empreintes ») de biopsies, après coloration standard (May-Grünwald Giemsa). Elle est pratiquée dans la plupart des laboratoires d’hématologie d’hôpitaux …

Lecture d’une cytologie ganglionnaire : proposition d’une procédure type

Karim Maloum, J.-F. Lesesve, Catherine Settegrana, Michel Feutrie et autres

Les étapes clés de la lecture d’une cytologie ganglionnaire sont proposées dans un document-cadre. Elles ont été validées par un panel de cytologistes impliqués dans cette analyse.

Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19

Aymeric Silvin, Nicolas Chapuis, Garett Dunsmore, Anne‐Gaëlle Goubet et autres

fr, sg, cn, il (code pays fourni par la source)

Too big for flow

Carole Almire, Nicolas Chapuis

![Figure][1] A 69-year-old woman who had a mastectomy with reconstruction using a textured implant 14 years ago presented with a periprosthetic effusion that was investigated for breast implant–associated anaplastic large-cell lymphoma (BIA-ALCL) by aspiration for cytology and flow

Un diagnostic inattendu devant une pancytopénie fébrile

Philippe Knoche, Élise Sourdeau, Éric Grignano, Carole Almire

Erythroblastopenia in a critically ill influenza patient

Shantha Valainathan, Damien Roux, Carole Almire, Béatrice La Combe

fr (code pays fourni par la source)