Gerrit Sijm

Development of Machine‐Assisted, Human‐Centred Bone Marrow Cell Classification: Feasibility Analysis in Patients With Myelodysplastic Syndromes

Kíyoyuki Ogata, Yuto Mochimaru, Leonie Saft, Gerrit Sijm et autres

Background: Cytomorphological examination and classification of bone marrow (BM) cells using a microscope is essential for diagnosing various diseases affecting the haematopoietic system. However, this requires expertise, is effort-intensive and is inherently subjective. Methods: We developed a method for automatically capturing BM …

us, se, nl, fr, jp (code pays fourni par la source)

An Acute Promyelocytic Leukemia Resistant to All-Trans Retinoic Acid: A Case Report of the ZBTB16::RARa Variant and Review of the Literature

Daan A R Castelijn, Gerrit Sijm, Bianca Venniker‐Punt, Pino J. Poddighe et autres

Introduction: Acute promyelocytic leukemia (APL) is characterized by the PML::RARa gene fusion and treatment consists of all-trans retinoic acid (ATRA). Rarely, genetic APL variants have been described which are insensitive to ATRA treatment and are therefore associated with a worse prognosis. Rapid …

nl (code pays fourni par la source)

Supplementary Material for: An acute promyelocytic leukemia resistant to all-trans retinoic acid: a case report of the ZBTB16::RARa variant and review of the literature

Castelijn D.A.R., Gerrit Sijm, Bianca Venniker‐Punt, Poddighe P.J. et autres

Introduction Acute promyelocytic leukemia (APL) is characterized by the PML::RARa gene fusion and treatment consists of all-trans retinoic acid (ATRA). Rarely, genetic APL variants have been described which are insensitive to ATRA treatment and are therefore associated with a worse prognosis. Rapid …

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Jacqueline Cloos, Jeffrey R. Harris, Jeroen J. W. M. Janssen, Angèle Kelder et autres

Response criteria in acute myeloid leukemia (AML) has recently been re-established, with morphologic examination utilized to determine whether patients have achieved complete remission (CR). Approximately half of the adult patients who entered CR will relapse within 12 months due to the outgrowth …

us, nl, be (code pays fourni par la source)

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Jacqueline Cloos, Jeffrey R. Harris, Jeroen J. W. M. Janssen, Angèle Kelder et autres

Response criteria in acute myeloid leukemia (AML) has recently been re-established, with morphologic examination utilized to determine whether patients have achieved complete remission (CR). Approximately half of the adult patients who entered CR will relapse within 12 months due to the outgrowth …

us, nl, be (code pays fourni par la source)