Anna Rehm

Community matters: stress tolerance and survival of Bacillus subtilis and Staphylococcus capitis in a synthetic space habitat consortium

Carolin Luisa Krämer, Yen Ly-Sauerbrey, Milina Maier, Luis Kadler et autres

Introduction: Conventional microbiological methods typically examine isolated bacterial species, which limits the insight into how microorganisms behave in more realistic, complex ecosystems. In contrast, synthetic bacterial consortia offer a practical and ecologically meaningful model for studying species interactions and responses to stress. …

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Is the Microbial Status an Extrinsic, Intrinsic, or Intermediate Influence on Experimental Animals?

Laurentiu Benga, Anna Rehm, Christina Gougoula, SC Bischoff et autres

Living entities, inlcuding laboratory animals, are composed of the host and its associated microbial communities and defined as holobionts. The host genotype and its microbiome drive together as a metagenome, the holobiont phenotype, with the microbiome itself as a well-recognized source of …

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Touching Surfaces – Presence of microorganisms on antimicrobial metal surfaces on the International Space Station and in German schools

Carolin L. Krämer, Daniel Wyn Müller, Franca Arndt, Anna Rehm et autres

Microorganisms are an integral component of human health on Earth as well as for life on the International Space Station. However, inescapably, fomites in human habitats can serve as crucial niches for opportunistic pathogens. To explore potential countermeasures for the associated infection …

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Multicenter exploration of microbial communities in hospital toilets reveals: antibiotic exposure in nosocomial settings selects for Enterococcus over commensal taxa

Claudio Neidhöfer, Marcel Neuenhoff, Esther Sib, Anna Rehm et autres

BACKGROUND: Excessive antibiotic utilization in hospital settings catalyzes the emergence and dissemination of multidrug resistant (MDR) bacteria, with sanitary facilities serving as critical vectors for their propagation. This study investigated the impact of patient antibiotic exposure on microbial diversity in hospital sanitary …

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The host genotype actively shapes its microbiome across generations in laboratory mice

Laurentiu Benga, Anna Rehm, Christina Gougoula, Philipp Westhoff et autres

BACKGROUND: The microbiome greatly affects health and wellbeing. Evolutionarily, it is doubtful that a host would rely on chance alone to pass on microbial colonization to its offspring. However, the literature currently offers only limited evidence regarding two alternative hypotheses: active microbial …

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FLASH Bragg-Peak Irradiation With a Therapeutic Carbon Ion Beam: First In Vivo Results

Walter Tinganelli, Anggraeini Puspitasari-Kokko, Olga Sokol, Alexander Helm et autres

PURPOSE: In recent years, ultra-high dose rate (UHDR) irradiation has emerged as a promising innovative approach to cancer treatment. Characteristic feature of this regimen, commonly referred to as FLASH effect, demonstrated primarily for electrons, photons, or protons, is the improved normal tissue …

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FLASH Bragg-peak irradiation with a therapeutic carbon ion beam: first in vivo results

Walter Tinganelli, Olga Sokol, Anggraeini Puspitasari, Alexander Helm et autres

Abstract Background and purpose In recent years, ultra-high dose rate (UHDR) irradiation has emerged as a promising innovative approach to cancer treatment. Characteristic feature of this regimen, commonly referred to as FLASH effect, demonstrated primarily for electrons, photons or protons, is the …

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ULTRA-HIGH DOSE RATE (FLASH) SOBP CARBON ION IRRADIATION: FIRST IN VIVO RESULTS

Walter Tinganelli, Anggraeini Puspitasari, Olga Sokol, Alexander Helm et autres

The host genotype actively shapes its microbiome across generations in laboratory mice

Laurentiu Benga, Anna Rehm, Christina Gougoula, Philipp Westhoff et autres

Abstract Background The microbiome greatly affects health and wellbeing. Evolutionarily, it is doubtful that a host would rely on chance alone to pass on microbial colonization to its offspring. However, the literature currently offers only limited evidence regarding two alternative hypotheses: active …

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Identification of staphyloxanthin and derivates in yellow-pigmented Staphylococcus capitis subsp. capitis

Katharina Siems, Katharina Runzheimer, Katarína Rebrošová, Lara Etzbach et autres

Introduction Staphylococcus capitis naturally colonizes the human skin but as an opportunistic pathogen, it can also cause biofilm-associated infections and bloodstream infections in newborns. Previously, we found that two strains from the subspecies S. capitis subsp. capitis produce yellow carotenoids despite the …

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Aruna Object Storage

Marius Alfred Dieckmann, Sebastian Beyvers, Jannis Hochmuth, Anna Rehm et autres

The exponential growth of scientific data has led to an increasing demand for effective data management and storage solutions. Academic computing infrastructures are often fragmented, which can make it challenging for researchers to leverage cloud-native principles and modern data analysis tools. To …

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Phenotypic and genomic assessment of the potential threat of human spaceflight-relevant Staphylococcus capitis isolates under stress conditions

Katharina Siems, Katharina Runzheimer, Anna Rehm, Oliver Schwengers et autres

Previous studies have reported that spaceflight specific conditions such as microgravity lead to changes in bacterial physiology and resistance behavior including increased expression of virulence factors, enhanced biofilm formation and decreased susceptibility to antibiotics. To assess if spaceflight induced physiological changes can …

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