FLASH Bragg-peak irradiation with a therapeutic carbon ion beam: first in vivo results
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Le résumé fourni par la source
Abstract Background and purpose In recent years, ultra-high dose rate (UHDR) irradiation has emerged as a promising innovative approach to cancer treatment. Characteristic feature of this regimen, commonly referred to as FLASH effect, demonstrated primarily for electrons, photons or protons, is the improved normal tissue sparing, while the tumor control is similar to the one of the conventional dose-rate (CDR) treatments. The FLASH mechanism is, however, unknown. One major question is whether this effect is maintained when using densely ionizing (high-LET) heavy nuclei. Materials and Methods Here we report the effects of 20 Gy UHDR heavy ion irradiation in clinically relevant conditions, i.e., at high-LET in the spread-out Bragg peak (SOBP) of a 12 C beam using an osteosarcoma mouse model. Results We show that UHDR irradiation was less toxic in the normal tissue compared to CDR while maintaining tumor control. The immune activation was also comparable in UHDR and CDR groups. We observed that the gut microbiome was altered in mice injected with the tumor compared to healthy animals, but both UHDR and CDR exposures steered the metagenome toward a balanced state. Conclusions The results show that the FLASH effect is safe and effective in heavy ion therapy and provide an important benchmark for the current mechanistic FLASH models. Highlights - FLASH irradiation with SOBP carbon ions spares normal tissue in mouse - Tumor control, immune response, and gut microbioma changes are induced at the same extent both at conventional and ultra-high dose rate - FLASH carbon ion irradiation is a safe and effective alternative to conventional radiotherapy.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- FLASH Bragg-peak irradiation with a therapeutic carbon ion beam: first in vivo results
- Date Crossref
- 16/07/2024
- Éditeur
- openRxiv
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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GSI Environmental (United States) pays non établi dans la noticeEntreprise
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Universities of Giessen and Marburg Lung Center pays non établi dans la noticeUniversité ou école supérieure
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Giessen School of Theology pays non établi dans la noticeUniversité ou école supérieure
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Dienstleistungszentrum Ländlicher Raum pays non établi dans la noticeInstitution
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Holland PTC pays non établi dans la noticeInstitution
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Uniparthenope pays non établi dans la noticeInstitution
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JLU Giessen pays non établi dans la noticeInstitution
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DLR pays non établi dans la noticeInstitution
GSI Environmental (United States), Universities of Giessen and Marburg Lung Center et Giessen School of Theology, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.