Simona Graziani

Italian healthcare professionals' real-world experience with immunization in children of non-European origin: the Vax4globe survey

Viviana Moschese, Simona Graziani, Antonietta Spadea, Maurizia d'Amore et autres

Introduction Nowadays vaccine hesitancy represents a significant current global health threat, causing reduced vaccine coverage with relevant effects on vulnerable populations. This study explores Italian healthcare professionals' (HCPs) experience with immunization of non-European (non-EU) origin children to implement targeted strategies for higher …

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Vaccinations in children of non-European origin: The Vax4globe survey

Viviana Moschese, Simona Graziani, Antonietta Spadea, Raffaella Mosco et autres

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IPINeT Ped-unPAD Study: Goals, Design, and Preliminary Results

Mayla Sgrulletti, Lucia Augusta Baselli, Riccardo Castagnoli, Elisabetta Del Duca et autres

Background: An unclassified primary antibody deficiency (unPAD) is a widely heterogeneous clinical entity, recently identified within the spectrum of Inborn Errors of Immunity (IEIs). Since unPAD has been traditionally considered as a mild condition, it has incorrectly received little attention, resulting in …

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The Inborn Errors of Immunity—Virtual Consultation System Platform in Service for the Italian Primary Immunodeficiency Network: Results from the Validation Phase

Emma Coppola, Mayla Sgrulletti, Manuela Cortesi, Roberta Romano et autres

PURPOSE: Inborn errors of immunity (IEI) represent a heterogeneous group of rare genetically determined diseases. In some cases, patients present with complex or atypical phenotypes, not fulfilling the accepted diagnostic criteria for IEI and, thus, at high risk of misdiagnosis or diagnostic …

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Allergic Manifestations of Inborn Errors of Immunity

Viviana Moschese, Emilia Cirillo, Giorgio Costagliola, Simona Graziani et autres

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Vaccine hesitancy and knowledge regarding maternal immunization among reproductive age women in central Italy: a cross sectional study

Viviana Moschese, Luigi De Angelis, Maria Vittoria Capogna, Simona Graziani et autres

Background Vaccination in pregnancy offers protection to the mother and the newborn. In Italy, influenza, pertussis, and COVID-19 vaccinations are recommended in pregnancy, but vaccination coverage is still far from the National Immunization Plan goals. We aimed to assess knowledge and attitude …

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The Evolutionary Scenario of Pediatric Unclassified Primary Antibody Deficiency to Adulthood

Mayla Sgrulletti, Giorgio Costagliola, Giuliana Giardino, Simona Graziani et autres

BACKGROUND: Unclassified primary antibody deficiency (unPAD) is a relatively novel inborn error of immunity (IEI) condition that can vary with time to more defined entities. Since long-term follow-up (FU) studies are scarce, we aimed to provide insight into the evolutionary clinical and …

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Case Report: Crossing a rugged road in a primary immune regulatory disorder

Mayla Sgrulletti, Cristina Cifaldi, Silvia Di Cesare, Barbara Kroegler et autres

Over the last decades, Inborn Errors of Immunity (IEI) characterized by an immune dysregulatory picture, isolated or combined with infections, have been increasingly identified and referred as Primary Immune Regulatory Disorders (PIRD). PIRD diagnosis may be difficult due to heterogeneity of time …

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Il vaccino anti SARS-CoV-2 e il suo impatto nei vulnerabili

Commissione Vaccini, Simona Graziani, Elisabetta Del Duca, Loredana Chini et autres

L’introduzione della vaccinazione per SARS-CoV-2 ha rappresentato un momento storico nel corso della pandemia che da circa 2 anni sta avendo un impatto sociale devastante in tutto il mondo. è noto, infatti, come l’immunità protettiva generata dalla vaccinazione favorisca un decorso più …

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Il vaccino anti SARS-CoV-2 e il suo impatto nei vulnerabili

Commissione Vaccini SIAIP, Simona Graziani, Elisabetta Del Duca, Loredana Chini et autres

L’introduzione della vaccinazione per SARS-CoV-2 ha rappresentato un momento storico nel corso della pandemia che da circa 2 anni sta avendo un impatto sociale devastante in tutto il mondo. è noto, infatti, come l’immunità protettiva generata dalla vaccinazione favorisca un decorso più …

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Pediatric health care professionals’ vaccine knowledge, awareness and attitude: a survey within the Italian Society of Pediatric Allergy and Immunology

Elisabetta Del Duca, Loredana Chini, Simona Graziani, Mayla Sgrulletti et autres

BACKGROUND: Physicians play a key role in driving vaccine acceptance and their recommendations are crucial to address vaccine hesitancy. The aim of the study was to assess knowledge, awareness and attitude of Italian Pediatric Health Care Professionals (pHCPs) on vaccinations. METHODS: An …

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Pediatric subset of primary immunodeficiency patients treated with SCIG: post hoc analysis of SHIFT and IBIS pooled data

Viviana Moschese, Clementina Canessa, Antonino Trizzino, Baldassarre Martire et autres

BACKGROUND: Primary immunodeficiencies (PID) constitute a heterogeneous group of more than 350 monogenetic diseases. PID patients with antibody impairment require lifelong administration of immunoglobulin G replacement therapy, administered either intravenously (IVIG) or subcutaneously (SCIG). Although the effectiveness of weekly and biweekly (every …

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