Deniz Ece Kaya

Genetic Analysis of Acral Melanomas From Southern African Patients

Bianca Tod, Yoonhee Nam, Deniz Ece Kaya, Maritha Kotze et autres

While the molecular characteristics of cutaneous melanomas (CMs) in individuals with light skin have been extensively studied, less is known about acral melanoma (AM), a non-ultraviolet radiation-induced melanoma more frequently found in individuals with darker skin. Exome and whole genome sequencing of …

Afrique du Sud, us, gb (code pays fourni par la source)

Clonal Dynamics of Hematopoiesis in Aplastic Anemia after Immunosuppression and Eltrombopag

Deniz Ece Kaya, Riley Cook, Simona Iacobelli, Giorgio Napolitani et autres

BACKGROUND: A Phase 3 randomized trial compared immunosuppressive therapy with or without eltrombopag in untreated patients with aplastic anemia (AA) and showed that addition of eltrombopag increased the rate, rapidity, and durability of hematological response, without increasing transformation to myeloid malignancies. We …

gb, nl, it, fr, ch, jp (code pays fourni par la source)

Deep immune signature of immune-mediated aplastic anemia patients shows distinct subsets of regulatory T cells associated with response to treatment: Results from the phase 3, randomized EBMT race clinical trial

Sıla Gerlevik, Giorgio Napolitani, Deniz Ece Kaya, Riley Cook et autres

Abstract Introduction: Immune-mediated aplastic anaemia (AA) is bone marrow failure syndrome, where T-cell mediated destruction of hematopoietic stem and progenitor cells (HSPCs) results in pancytopenia. Overall, two third of patient respond to immune suppressive therapy (IST) with antithymocyte globulin (ATG) and cyclosporine …

gb, nl, it, fr, ch, jp, us (code pays fourni par la source)

The CSMD1 gene is involved in hematopoietic stem cell HSC pruning in patients with acquired immune-mediated aplastic anemia

Antonio M. Risitano, Deniz Ece Kaya, S. Iacobelli, Riley Cook et autres

Abstract Introduction Somatic mutations in Hematopoietic Stem Cells and Progenitors (HSC/HCP) are very frequent in patients with acquired Immune-mediated Aplastic Anemia (IAA) being found in about a third of patients at diagnosis and up to 65-75% after Immuno-Suppressive Treatment (IST). In our …

it, gb, fr, jp (code pays fourni par la source)

Saudi Acute Myeloid Leukaemia (AML) Genome Reveals Significant Differences from That in the Western Population

Manar S. A. Al-Faham, Syed Osman Ahmed, Nogayhan Seymen, Mohamed Abouelhoda et autres

Introduction AML genome in the western populations has provided pathogenetic insights, prognosticators and selection of appropriate therapies. AML genome in the Middle East may differ from that in the west, because of younger population, racial, environmental and cultural factors including high consanguinity. …

gb, sa (code pays fourni par la source)

Adaptation to space conditions of novel bacterial species isolated from the International Space Station revealed by functional gene annotations and comparative genome analysis

Lukasz M. Szydlowski, Alper Bülbül, Anna Simpson, Deniz Ece Kaya et autres

BACKGROUND: The extreme environment of the International Space Station (ISS) puts selective pressure on microorganisms unintentionally introduced during its 20+ years of service as a low-orbit science platform and human habitat. Such pressure leads to the development of new features not found …

pl, tr, us (code pays fourni par la source)

Comparison of the oral microbiota of children with autism spectrum disorder in primary dentition with neurotypical controls

Gülsevim Oda, Deniz Ece Kaya, Tuba Bilbay Kaynar, Murat Coşkun et autres

tr, gb (code pays fourni par la source)

Identification of novel myelodysplastic syndromes prognostic subgroups by integration of inflammation, cell-type composition, and immune signatures in the bone marrow

Sıla Gerlevik, Nogayhan Seymen, Shan Hama, Warisha Mumtaz et autres

Mutational profiles of myelodysplastic syndromes (MDS) have established that a relatively small number of genetic aberrations, including SF3B1 and SRSF2 spliceosome mutations, lead to specific phenotypes and prognostic subgrouping. We performed a multi-omics factor analysis (MOFA) on two published MDS cohorts of …

gb, au (code pays fourni par la source)

Author response: Identification of novel myelodysplastic syndromes prognostic subgroups by integration of inflammation, cell-type composition, and immune signatures in the bone marrow

Sıla Gerlevik, Nogayhan Seymen, Shan Hama, Warisha Mumtaz et autres

gb (code pays fourni par la source)

Author response: Identification of novel myelodysplastic syndromes prognostic subgroups by integration of inflammation, cell-type composition, and immune signatures in the bone marrow

Sıla Gerlevik, Nogayhan Seymen, Shan Hama, Warisha Mumtaz et autres

Mutational profiles of Myelodysplastic syndromes (MDS) have established that a relatively small number of genetic aberrations, including SF3B1 and SRSF2 spliceosome mutations, lead to specific phenotypes and prognostic subgrouping. We performed a Multi-Omics Factor Analysis (MOFA) on two published MDS cohorts of …

gb (code pays fourni par la source)

Identification of novel myelodysplastic syndromes prognostic subgroups by integration of inflammation, cell-type composition, and immune signatures in the bone marrow

Sıla Gerlevik, Nogayhan Seymen, Shan Hama, Warisha Mumtaz et autres

Abstract Mutational profiles of Myelodysplastic syndromes (MDS) have established that a relatively small number of genetic aberrations, including SF3B1 and SRSF2 spliceosome mutations, lead to specific phenotypes and prognostic subgrouping. We performed a Multi-Omics Factor Analysis (MOFA) on two published MDS cohorts …

gb, au (code pays fourni par la source)

Reviewer #1 (Public Review): Identification of novel myelodysplastic syndromes prognostic subgroups by integration of inflammation, cell-type composition, and immune signatures in the bone marrow

Sıla Gerlevik, Shan Hama, Nogayhan Seymen, Warisha Mumtaz et autres

Mutational profiles of Myelodysplastic syndromes (MDS) have established that a relatively small number of genetic aberrations, including SF3B1 and SRSF2 spliceosome mutations, lead to specific phenotypes and prognostic subgrouping. We performed a Multi-Omics Factor Analysis (MOFA) on two published MDS cohorts of …