Calman A. MacLennan

Association between anaemia, micronutrient status, and pneumococcal vaccine responses in young Kenyan children

Kelvin M. Abuga, Henry Karanja, Katherine Gallagher, Bridgious Walusimbi et autres

Abstract Anaemia and micronutrient deficiencies are common in low- and middle-income countries, but whether nutritional status influences pneumococcal vaccine immunogenicity in children remains poorly characterised. We examined associations between pneumococcal vaccine responses in 670 Kenyan children enrolled in three vaccine trials: PRISM …

Kenya, Ouganda, gb, us, at (code pays fourni par la source)

Shigella's perfect storm

Calman A. MacLennan

gb (code pays fourni par la source)

Preclinical characterization of immune responses induced by a candidate gonococcal native outer membrane vesicle vaccine

Ilaria Onofrio, Sthefany Pagliari, A. Francis, Molly E Quinn et autres

ABSTRACT Neisseria gonorrhoeae poses significant public health challenges due to multidrug-resistant gonorrhea and severe reproductive health complications of untreated infection. No vaccine is licensed to prevent gonorrhea. However, the meningococcal outer membrane vesicle (OMV)-containing vaccine, 4CMenB, provides moderate cross-protection against gonorrhea. We …

gb (code pays fourni par la source)

Safety and Immunogenicity of 20-valent Pneumococcal Conjugate Vaccine According to Number and Timing of Primary Series Doses

Mary Kline, Anne L. Wyllie, Kathleen McElwee, James Trammel et autres

BACKGROUND: The number and timing of pneumococcal conjugate vaccine (PCV) primary doses can impact infant immune responses. This descriptive post hoc analysis evaluates the 20-valent PCV (PCV20) immunogenicity by vaccination timing in healthy infants in 2 key phase 3 trials. METHODS: Immunogenicity …

us, fr, gb, de (code pays fourni par la source)

Pre-clinical efficacy of a candidate outer membrane vesicle gonococcal vaccine in comparison with 4CMenB

Paula Freixeiro, Lisa A. Lewis, Leonor Sánchez-Busó, Magnus Unemo et autres

Abstract Neisseria gonorrhoeae causes 82 million global cases of gonorrhoea annually. Multidrug-resistant gonococci threaten to make gonorrhoea untreatable. Meningococcal vaccines MeNZB and 4CMenB (Bexsero), containing Neisseria meningitidis group B detergent-extracted outer membrane vesicles (dOMV), cross-protect against gonorrhoea with 31–59% effectiveness. We hypothesised …

gb, us, es, se, no (code pays fourni par la source)

Preclinical characterization of immune responses induced by a candidate gonococcal native Outer Membrane Vesicle vaccine

Ilaria Onofrio, Sthefany Pagliari, A. Francis, Molly E Quinn et autres

Abstract Background Neisseria gonorrhoeae poses significant public health challenges due to multidrug-resistant gonorrhoeic and severe reproductive health complications of untreated infection. No vaccine is licensed to prevent gonorrhea. However, the meningococcal outer membrane vesicle (OMV)-containing vaccine, 4CMenB, provides moderate cross-protection against gonorrhea. …

gb (code pays fourni par la source)

Age-Specific Concentrations and Seroprevalence of Antibodies Against Salmonella Enteritidis (O:9) and Salmonella Typhimurium (O:4,5) Across 3 Sites in Kenya

Esther Muthumbi, Sean C. Elias, Alfred Mwanzu, Agnes Mutiso et autres

BACKGROUND: Seroprevalence studies can indicate the age distribution of first infection with nontyphoidal Salmonella and estimate the rate of infection by age. METHOD: We collected 1254 paired samples of serum and stool from healthy children and adults in Kilifi, Nairobi, and Siaya …

Kenya, gb, Ouganda, de, hr (code pays fourni par la source)

Vaccines and antimicrobial resistance: from science to policy—summary and outcomes

Calman A. MacLennan, Mateusz Hasso-Agopsowicz, Kelvin M. Abuga, Richard A. Adegbola et autres

In April 2024, the Royal Society convened a Science+ meeting in London on 'Vaccines and antimicrobial resistance: from science to policy'. The purpose was to review the science of how vaccines reduce antimicrobial resistance (AMR) and discuss policy in advancing development and …

gb, us, pk, Kenya, Nigéria, nl, ie, Zambie, no, is, be, th, ca, br, Tanzanie, it, ch, fr (code pays fourni par la source)

Lessons from COVID-19: the 100 Days Mission and antimicrobial resistance

Richard Hatchett, Calman A. MacLennan

The COVID-19 pandemic demonstrated the capacity of the world to rapidly mobilize resources and political will when faced with an immediate, visible global threat. The accelerated development of effective vaccines inspired the Coalition for Epidemic Preparedness Innovations to promote the 100 Days …

us, no, gb (code pays fourni par la source)

The invasive non-typhoidal Salmonella vaccine landscape: Innovations and challenges ahead

Nicole M. Revie, Matthew Guo, Anne E. Mullin, Annelies Wilder-Smith et autres

kr, ch, gb (code pays fourni par la source)

Multi-laboratory study to evaluate the performance of a harmonised ELISA protocol to detect serum IgG specific for Shigella flexneri 2a LPS.

Caroline Vipond, Paul Stickings, Peter Rigsby, Danielle Carson et autres

gb, us, il (code pays fourni par la source)

Pre-clinical efficacy of a candidate Outer Membrane Vesicle gonococcal vaccine in comparison with 4CMenB.

Paula Freixeiro, Lisa A. Lewis, Leonor Sánchez-Busó, Magnus Unemo et autres

gb, es, se, no (code pays fourni par la source)