Adele Leggieri

F11. NEURAL CIRCUIT DYSREGULATION IN RBFOX1 MUTANT ZEBRAFISH

Maja Rebecca Adel, Ester Antón-Galindo, Manuel Tobías-Olave, Ana Martos-Guillamet et autres

Background The splicing factor RBFOX1 exerts pleiotropic effects on numerous neurodevelopmental and psychiatric disorders. Previous studies by our group in two zebrafish lines showed that mutations in rbfox1 lead to hyperactivity, increased thigmotaxis, and social impairments. However, the biological mechanisms underlying these …

at, es, gb, ca (code pays fourni par la source)

Disrupting fzd9b in Zebrafish Recapitulates Stress- and Anxiety-Like Behaviours Relevant to Williams Syndrome

Jose Vicente Torres-Pérez, Adele Leggieri, Xian Wang, Aine Kehoe et autres

Williams syndrome (WS) is a multifaceted developmental disorder characterized by a spectrum of physical and intellectual traits. Individuals with WS exhibit friendly, impulsive, and hyper-social behaviours, often coupled with anxiety. WS is caused by a hemizygous microdeletion on chromosome 7q11.23. Among the …

es, gb (code pays fourni par la source)

rbfox1 LoF mutants show disrupted bdnf/trkb2 and crhb/nr3c2 expression and increased cortisol levels during development coupled with signs of allostatic overload in adulthood

Adele Leggieri, Judit García‐González, Saeedeh Hosseinian, Peter Ashdown et autres

Mutations in the RBFOX1 gene are associated with psychiatric disorders but how RBFOX1 influences psychiatric disorder vulnerability remains unclear. Recent studies showed that RBFOX proteins mediate the alternative splicing of PAC1, a critical HPA axis activator. Further, RBFOX1 dysfunction is linked to …

gb, us, es (code pays fourni par la source)

Housing and husbandry factors affecting zebrafish novel tank test responses: a global multi-laboratory study

Courtney Hillman, Barbara Dotto Fontana, Tamara G. Amstislavskaya, М. А. Gorbunova et autres

The reproducibility crisis in bioscience, characterized by inconsistent study results, impedes our understanding of biological processes. Global collaborative studies offer a unique solution to this problem. Here, we present a global collaboration using the zebrafish (Danio rerio) novel tank test, a popular …

gb, us, br, ru, au, cl, ar, az, pt, cn (code pays fourni par la source)

AIP deficiency in zebrafish causes loss of intestinal epithelial differentiation via disrupted wnt signaling

Xian Wang, Oliver Haworth, Sayka Barry, Adele Leggieri et autres

N-isopropylacrylamide based nanogels crossing the blood-brain barrier: evidence of high in vitro internalization in human endothelial cells and in vivo permeation in zebrafish

Roberta Bilardo, Adele Leggieri, Francesca Tomatis, Federico Traldi et autres

The development of effective neurological treatments remains a challenge due to the low permeation across the blood-brain barrier (BBB). The use of nanoparticles for brain drug delivery is promising, but the level of BBB crossing remains low, typically around 0.5-3%. We report …

gb, pt, fr (code pays fourni par la source)

N-isopropylacrylamide based nanogels crossing the blood-brain barrier: evidence of high in vitro internalization in human endothelial cells and in vivo permeation in zebrafish

Roberta Bilardo, Adele Leggieri, Francesca Tomatis, Federico Traldi et autres

The development of effective neurological treatments remains a challenge due to the low permeation across the blood-brain barrier (BBB). The use of nanoparticles for brain drug delivery is promising, but the level of BBB crossing remains low, typically around 0.5-3%. We report …

gb, pt, fr (code pays fourni par la source)

Housing and Husbandry Factors Affecting Zebrafish (Danio rerio) Novel Tank Test Responses: A Global Multi-Laboratory Study

Matthew O. Parker, Courtney Hillman, Barbara Dotto Fontana, Tamara G. Amstislavskaya et autres

gb, br, ru, au, cl, us, ar, Somalie, ag, pt, cn (code pays fourni par la source)

rbfox1 LoF mutants show disrupted bdnf/trkb2 and crhb/nr3c2 expression and increased cortisol levels during development coupled with signs of allostatic overload in adulthood

Adele Leggieri, Judit García‐González, Saeedeh Hosseinian, Peter Ashdown et autres

ABSTRACT Mutations in the RBFOX1 gene are associated with psychiatric disorders but how RBFOX1 influences psychiatric disorder vulnerability remains unclear. Recent studies showed that RBFOX proteins mediate the alternative splicing of PAC1, a critical HPA axis activator. Further, RBFOX1 dysfunction is linked …

gb, us, es (code pays fourni par la source)

Pleiotropic contribution of rbfox1 to psychiatric and neurodevelopmental phenotypes in two zebrafish models

Ester Antón-Galindo, Maja R. Adel, Judit García‐González, Adele Leggieri et autres

Abstract RBFOX1 is a highly pleiotropic gene that contributes to several psychiatric and neurodevelopmental disorders. Both rare and common variants in RBFOX1 have been associated with several psychiatric conditions, but the mechanisms underlying the pleiotropic effects of RBFOX1 are not yet understood. …

es, de, gb, us (code pays fourni par la source)

Disrupting fzd9b in zebrafish recapitulates stress- and anxiety-like behaviours associated with Williams syndrome

Jose Vicente Torres-Pérez, Adele Leggieri, Aleksandra M. Mech, Sofia Anagianni et autres

Abstract Williams syndrome (WS) is a multifaceted developmental disorder characterized by a spectrum of physical and intellectual traits. Individuals with WS exhibit friendly, impulsive, and hyper-social behaviours, often coupled with anxiety. WS is attributed to a microdeletion on chromosome 7q11.23, affecting several …

es, gb (code pays fourni par la source)

Aryl hydrocarbon receptor-interacting protein (aip) loss causes failure-to-thrive and cardiac defects in zebrafish

Xian Wang, Oliver Haworth, Adele Leggieri, Márta Korbonits et autres

Aryl hydrocarbon receptor-interacting protein (AIP) is a highly expressed, evolutionary conserved little-known co-chaperone molecule that can bind to client proteins. Heterozygous loss-of-function mutations of AIP are associated with pituitary adenomas. Multiple lines of evidence suggest that AIP has important functions beyond the …