Marja A. Heiskanen

Exercise Training Improves Skeletal Muscle Insulin Sensitivity and Reprograms the Adipose Transcriptome in Heavier Monozygotic Twins

Jaakko Hentilä, Max Ullrich, Ronja Ojala, Martin S. Lietzén et autres

Exercise training improves skeletal muscle insulin sensitivity, yet its effects on white adipose tissue remain incompletely understood. We investigated how adiposity and exercise training influence insulin-stimulated glucose uptake in skeletal muscle and abdominal subcutaneous adipose tissue (ASAT), alongside adaptations in gene expression …

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Association of leisure time physical activity with gut microbiota composition in early adulthood

Hanna-Mari Boelius, Anna‐Katariina Aatsinki, Marja A. Heiskanen, Eero A. Haapala et autres

Physical activity is associated with compositional changes in gut microbiota. Studies applying data from general populations exhibiting varying physical activity levels are scarce. This study investigated the associations between leisure time physical activity and gut microbiota composition in a general population of …

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Factors related to blood-based biomarkers for neurodegenerative diseases and their intergenerational associations in the Young Finns Study: a cohort study

Marja A. Heiskanen, Juha Mykkänen, Katja Pahkala, Markus Juonala et autres

BACKGROUND: Blood-based biomarkers (BBM) of neurodegenerative diseases are emerging as cost-effective tools in the differential diagnostics of Alzheimer's disease and other dementias. Scarce data exist about factors explaining BBM variation in population-based cohorts, and their intergenerational associations are unknown. This study aimed …

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The role of early life factors and green living environment in the development of gut microbiota in infancy: Population-based cohort study

Minka Ovaska, Manu Tamminen, Mirkka Lahdenperä, Jussi Vahtera et autres

Objective Early life microbial exposure influences the composition of gut microbiota. We investigated how early life factors, and the green living environment around infants’ homes, influence the development of gut microbiota during infancy by utilizing data from the Steps to Healthy Development …

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Regular Exercise Training Induces More Changes on Intestinal Glucose Uptake from Blood and Microbiota Composition in Leaner Compared to Heavier Individuals in Monozygotic Twins Discordant for BMI

Martin S. Lietzén, Maria Angela Guzzardi, Ronja Ojala, Jaakko Hentilä et autres

Background/Objectives: Obesity impairs intestinal glucose uptake (GU) (intestinal uptake of circulating glucose from blood) and alters gut microbiome. Exercise improves intestinal insulin-stimulated GU and alters microbiome. Genetics influence the risk of obesity and gut microbiome. However, the role of genetics on the …

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Cognitive performance from childhood to old age and intergenerational correlations in the multigenerational Young Finns Study

Marja A. Heiskanen, Jaakko Nevalainen, Katja Pahkala, Markus Juonala et autres

BACKGROUND: Cognitive performance changes during the lifespan, but the information is gathered from studies on separate age cohorts. Computerized neurocognitive testing enables efficient and similar assessments for all ages. We investigated (i) the effect of age at different stages of life and …

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Change in cognitive performance during seven-year follow-up in midlife is associated with sex, age, and education – The Cardiovascular Risk in Young Finns Study

Marja A. Heiskanen, Jaakko Nevalainen, Katja Pahkala, Markus Juonala et autres

OBJECTIVE: Sex, age, and education are associated with the level of cognitive performance. We investigated whether these factors modulate the change in cognitive performance in midlife by leveraging the longitudinal data from the Cardiovascular Risk in Young Finns Study (YFS). METHODS: Participants …

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Mechanisms Leading to Increased Insulin-Stimulated Cerebral Glucose Uptake in Obesity and Insulin Resistance: A High-Fat Diet and Exercise Training Intervention PET Study with Rats (CROSRAT)

Anna Jalo, Jatta S. Helin, Jaakko Hentilä, Tuuli A. Nissinen et autres

Recent studies have shown that obesity and insulin resistance are associated with increased insulin-stimulated glucose uptake (GU) in the brain. Thus, insulin sensitivity seems to work differently in the brain compared to the peripheral tissues like skeletal muscles, but the underlying mechanisms …

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Association of Long-Term Habitual Dietary Fiber Intake since Infancy with Gut Microbiota Composition in Young Adulthood

Marja A. Heiskanen, Anna‐Katariina Aatsinki, Petra Hakonen, Noora Kartiosuo et autres

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The Role of Early Life Factors and Green Living Environment in the Development of Gut Microbiota in Infancy: Population-Based Cohort Study

Minka Ovaska, Manu Tamminen, Mirkka Lahdenperä, Jussi Vahtera et autres

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Bone marrow metabolism is affected by body weight and response to exercise training varies according to anatomical location

Ronja Ojala, Jaakko Hentilä, Martin S. Lietzén, Milja Arponen et autres

Abstract Aim High body weight is a protective factor against osteoporosis, but obesity also suppresses bone metabolism and whole‐body insulin sensitivity. However, the impact of body weight and regular training on bone marrow (BM) glucose metabolism is unclear. We studied the effects …

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Author response for "Bone marrow metabolism is affected by body weight and response to exercise training varies according to anatomical location"

Ronja Ojala, Jaakko Hentilä, Martin S. Lietzén, Milja Arponen et autres