Tiziana Di Matola

Sodium–glucose cotransporter 2 inhibitors in breast cancer patients on endocrine therapy: a targeted strategy to mitigate long-term cardiometabolic risk

Vincenzo Quagliariello, Massimiliano Berretta, Irma Bisceglia, Matteo Barbato et autres

BACKGROUND: Hormone receptor-positive breast cancer (HR+ BC) represents the most common breast cancer subtype and is increasingly characterized by long-term survivorship complicated by substantial cardiometabolic and cardiovascular morbidity. Endocrine therapies, including aromatase inhibitors, selective estrogen receptor modulators and degraders, and ovarian suppression, …

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Environmental endocrine disruptors in cardio-oncology: emerging modifiers of cardiovascular vulnerability in patients with cancer

Vincenzo Quagliariello, Massimiliano Berretta, Giuseppe D’aiuto, Irma Bisceglia et autres

BACKGROUND: Cardio-oncology has traditionally focused on treatment-related cardiovascular toxicity and conventional cardiovascular risk factors. However, increasing evidence suggests that environmental exposures may contribute to both cancer development and cardiovascular disease through shared biological mechanisms. Endocrine-disrupting chemicals (EDCs) are ubiquitous environmental contaminants capable …

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Heart-Type Fatty Acid-Binding Protein (H-FABP) as a Candidate Adjunctive Biomarker for Immune Checkpoint Inhibitor-Related Cardiotoxicity: Linking Early Immune–Metabolic Myocardial Injury with Translational Cardio-Oncology

Vincenzo Quagliariello, Massimiliano Berretta, Fabrizio Maurea, Maria Laura Canale et autres

Immune checkpoint inhibitors (ICIs) have transformed the therapeutic landscape of oncology but are increasingly associated with cardiovascular immune-related adverse events (irAEs), including myocarditis, heart failure, arrhythmias, and vascular complications. Among these, ICI-associated myocarditis represents the most severe manifestation, often characterized by high …

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SGLT2 Inhibitor Dapagliflozin Attenuates Cardiomyocyte Injury and Inflammation Induced by PI3Kα-Selective Inhibitor Alpelisib and Fulvestrant Under Hyperglycemia

Vincenzo Quagliariello, Massimiliano Berretta, Matteo Barbato, Fabrizio Maurea et autres

Activating PIK3CA mutations occur in approximately 40% of hormone receptor-positive (HR+)/HER2-negative breast cancers and represent a major driver of endocrine resistance. The PI3Kα-selective inhibitor alpelisib, in combination with fulvestrant, significantly improves progression-free survival in patients with PIK3CA-mutant disease, as demonstrated in the …

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A Rare Combination of High‐Affinity Hemoglobin, Non‐Transfusion‐Dependent Thalassemia (Αlpha‐Triplication and Codon 39 Mutation), and Hereditary Stomatocytosis

Carmina Fatigati, Silvia Costantini, Immacolata Andolfo, Maria Rosaria Storino et autres

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Overview on Hereditary Spherocytosis Diagnosis

A. Polizzi, Luca P. DICEMBRE, C. Failla, Tiziana Di Matola et autres

INTRODUCTION: Hereditary spherocytosis (HS) is a congenital haemolytic disorder, resulting from plasma membrane protein deficiency of red blood cells (RBCs). Typical pathological signs are anemia, jaundice, and splenomegaly; in newborns, jaundice is the main symptom. MATERIAL AND METHODS: This study focused on …

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Cytokine signature and COVID-19 prediction models in the two waves of pandemics

Serena Cabaro, Vittoria D’Esposito, Tiziana Di Matola, Silvia Sale et autres

In Europe, multiple waves of infections with SARS-CoV-2 (COVID-19) have been observed. Here, we have investigated whether common patterns of cytokines could be detected in individuals with mild and severe forms of COVID-19 in two pandemic waves, and whether machine learning approach …

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Clinical Outcome Prediction in COVID-19 Patients by Lymphocyte Subsets Analysis and Monocytes’ iTNF-α Expression

Gabriele Madonna, Silvia Sale, Mariaelena Capone, Chiara De Falco et autres

In December 2019, a novel coronavirus, "SARS-CoV-2", was recognized as the cause of coronavirus disease 2019 (COVID-19). Several studies have explored the changes and the role of inflammatory cells and cytokines in the immunopathogenesis of the disease, but until today, the results …

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Cytokine Signature and COVID-19 Prediction Models in the Two Waves of Pandemics.

Serena Cabaro, Vittoria D’Esposito, Tiziana Di Matola, Silvia Sale et autres

Abstract In Europe, two waves of infections with SARS-CoV-2 (COVID-19) have been observed to date. Here, we have investigated whether common patterns of cytokines could be detected in individuals with mild and severe forms of COVID-19 in the two pandemic waves, and …

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Rechallenging to Hydroxycarbamide Post Thalidomide Treatment and Response in a Non Transfusion-Dependent Patient, is it Possible?

Paolo Ricchi, Silvia Costantini, Anna Spasiano, Patrizia Cinque et autres

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Utility of peripheral blood smear in rapid diagnosis of Pertussis

Tiziana Di Matola, Ciro Miele, Maurizio Coppola, Maurizio Fumi et autres

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Is there a difference in phenotype between males and females with non-transfusion-dependent thalassemia? A cross-sectional evaluation

Maria Marsella, Massimiliano Ammirabile, Tiziana Di Matola, Alessia Pepe et autres

OBJECTIVES: Non-transfusion-dependent thalassemia includes a variety of phenotypes and genotypes that rarely require regular transfusions. However, these patients can experience a wide range of complications. The objective of this retrospective study was to verify whether there is a significant difference in non-transfusion-dependent …

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