Unnati Kapadnis

LRRK2-targeting antisense oligonucleotide in Parkinson’s disease: a phase 1 randomized controlled trial

Omar S. Mabrouk, B. Tichler, H. Moore Arnold, Eva C. Thoma et autres

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Novel method for detection of UBE3A protein in CSF from individuals with Angelman syndrome

Omar S. Mabrouk, Nicole T. Comfort Harris, Robert W. Komorowski, Kyle B. Fraser et autres

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Identification and validation of N-acetylputrescine in combination with non-canonical clinical features as a Parkinson’s disease biomarker panel

Kuan‐Wei Peng, Allison Klotz, Arcan Güven, Unnati Kapadnis et autres

Parkinson's disease is a progressive neurodegenerative disorder in which loss of dopaminergic neurons in the substantia nigra results in a clinically heterogeneous group with variable motor and non-motor symptoms with a degree of misdiagnosis. Only 3-25% of sporadic Parkinson's patients present with …

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Volumetric Absorptive Microsampling as An Effective Microsampling Technique for LC–MS/MS Bioanalysis of Biomarkers in Drug Discovery

Unnati Kapadnis, Chuck W. Locuson, Heidi Okamura, Gianluca De Rienzo et autres

Aim: Develop and validate a volumetric absorptive microsampling (VAMS)-based LC–MS/MS method to support the bioanalysis of amino acid and carboxylic acid biomarkers in mouse whole blood. Method: Mouse whole blood was collected using a 10 μl VAMS device. The analytes in VAMS …

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Mitapivat increases ATP and decreases oxidative stress and erythrocyte mitochondria retention in a SCD mouse model

Zenaide Quezado, Sayuri Kamimura, Meghann L. Smith, Xunde Wang et autres

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Identification and Validation of N-Acetylputrescine in Combination With Non-Canonical Clinical Features As a Parkinson’s Disease Biomarker Panel

Kuan‐Wei Peng, Allison Klotz, Arcan Güven, Unnati Kapadnis et autres

Abstract Parkinson’s disease is a progressive neurodegenerative disorder in which loss of dopaminergic neurons in the substantia nigra results in a clinically heterogeneous group with variable motor and non-motor symptoms with a degree of misdiagnosis. Only 3-5% of sporadic Parkinson’s patients present …

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-Itaconate confers tolerance to late NLRP3 inflammasome activation

Monika Bambousková, Lucie Potůčková, Tomáš Paulenda, Martina Kerndl et autres

Abstract Itaconate is a unique regulatory metabolite that is induced upon toll-like receptor (TLR) stimulation in myeloid cells. Here, we demonstrate major inflammatory tolerance and cell death phenotypes associated with itaconate production in activated macrophages. We show that endogenous itaconate is a …

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Itaconate confers tolerance to late NLRP3 inflammasome activation

Monika Bambousková, Lucie Potůčková, Tomáš Paulenda, Martina Kerndl et autres

Itaconate is a unique regulatory metabolite that is induced upon Toll-like receptor (TLR) stimulation in myeloid cells. Here, we demonstrate major inflammatory tolerance and cell death phenotypes associated with itaconate production in activated macrophages. We show that endogenous itaconate is a key …

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