Belén Picatoste

La deficiencia del receptor de inmunoglobulinas poliméricas en el linaje hematopoyético atenúa la aterosclerosis experimental

Isabel Cerro-Pardo, Belén Picatoste, Cristina Márquez-Gálvez, Lucía Ortega-Villanueva et autres

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Polymeric immunoglobulin receptor deficiency attenuates experimental atherosclerosis

Isabel Cerro-Pardo, Belén Picatoste, Irene Raposo-Gutiérrez, Inmaculada Martos-Folgado et autres

Background Polymeric immunoglobulin receptor (PIGR) is a transmembrane protein widely expressed in mucosal epithelial cells that is involved in the transcytosis of the polymeric immunoglobulins IgA and IgM. Recent findings revealed increased plasma PIGR levels in subjects with subclinical atherosclerosis, although its …

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Correction to: “Cardioprotective Effect of Empagliflozin and Circulating Ketone Bodies During Acute Myocardial Infarction”

Carlos G. Santos‐Gallego, Juan Antonio Requena-Ibáñez, Belén Picatoste, Brian Fardman et autres

Extracellular vesicles and the lipid messengers: The adipose tissue connection to cancer and metabolic disease.

Belén Picatoste, Heidy M Guamán, Marina Herrero-Matesanz, Laura V Piñeres et autres

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Immunoglobulin A/PIGR axis as potential mediators of human abdominal aortic aneurysms revealed by topologically resolved proteomics

Isabel Cerro-Pardo, Estefanía Núñez, Belén Picatoste, Cristina Márquez-Gálvez et autres

Abstract Background Abdominal aortic aneurysm (AAA) is an asymptomatic chronic disease of the aorta and its evolution is unpredictable. Despite the existence of several pathological mechanisms contributing to the dilation of the human AAA wall, there is currently no specific therapy to …

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Development of SOCS1 mimetics as novel approach to harmonize inflammation, oxidative stress, and fibrogenesis in metabolic dysfunction-associated steatotic liver disease

Susana Bernal, Ignacio Priéto, María Kavanagh, Isabel Herrero del Real et autres

BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent chronic liver disease, encompassing a spectrum from simple steatosis to steatohepatitis (MASH), cirrhosis, and hepatocellular carcinoma. As part of metabolic syndrome, MASLD/MASH is characterized by inflammation, oxidative stress, and fibrosis, highlighting the …

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Additional file 4 of Immunoglobulin A/PIGR axis as potential mediators of human abdominal aortic aneurysms revealed by topologically resolved proteomics

Isabel Cerro-Pardo, Estefanía Núñez, Belén Picatoste, Cristina Márquez-Gálvez et autres

Additional file 4. Figure 1.- diagram of the study setup design. Figure 2.- functional enrichment analysis of proteins significantly increased in aaa medial and adventitial layers. Figure 3.- mrna expression analysis in homogenates of medial and adventitial layers of control aortas and …

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Spatiotemporal regulation of GIPR signaling impacts glucose homeostasis as revealed in studies of a common GIPR variant

Lucie Yammine, Belén Picatoste, Nazish Abdullah, Rosemary A. Leahey et autres

OBJECTIVE: Glucose-dependent insulinotropic polypeptide (GIP) has a role in controlling postprandial metabolic tone. In humans, a GIP receptor (GIPR) variant (Q354, rs1800437) is associated with a lower body mass index (BMI) and increased risk for Type 2 Diabetes. To better understand the …

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Cardioprotective Effect of Empagliflozin and Circulating Ketone Bodies During Acute Myocardial Infarction

Carlos G. Santos‐Gallego, Juan Antonio Requena-Ibáñez, Belén Picatoste, Brian Fardman et autres

BACKGROUND: SGLT2i (sodium-glucose cotransporter-2 inhibitors) improve clinical outcomes in patients with heart failure, but the mechanisms of action are not completely understood. SGLT2i increases circulating levels of ketone bodies, which has been demonstrated to enhance myocardial energetics and induce reverse ventricular remodeling. …

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Protection of diabetes in aortic abdominal aneurysm: Are antidiabetics the real effectors?

Belén Picatoste, Isabel Cerro-Pardo, Luis Miguel Blanco‐Colio, José Luis Martı́n-Ventura

Aortic aneurysms, including abdominal aortic aneurysms (AAAs), is the second most prevalent aortic disease and represents an important cause of death worldwide. AAA is a permanent dilation of the aorta on its infrarenal portion, pathologically associated with oxidative stress, proteolysis, vascular smooth …

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Cardioprotective effect of empagliflozin in acute myocardial infarction: the role of ketone bodies availability

J J Badimón, Carlos G. Santos‐Gallego, Juan Antonio Requena-Ibáñez, Belén Picatoste et autres

Abstract Background The cardio-renal benefits of SGLT2i have been clearly established by clinical trials. Of interest, despite not having any effect on the incidence of classic atherothrombotic events (MI and strokes), patients receiving SGLT2i treatment had a higher chance of surviving myocardial …

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Complement C5 plasma levels are associated to abdominal aortic aneurysm prevalence and progression

Diego Martínez-López, Nerea Méndez‐Barbero, Raquel Roldán-Montero, Isabel Cerro-Pardo et autres

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Complemento II-CM La Caixa Aim Previous human and experimental studies have suggested a role of complement activation in abdominal aortic aneurysm (AAA). We recently described an …

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