Katarzyna B. Lewandowska

C39-19 Duration of Symptoms, Overall Survival and Fvc and Dlco Decline in Idiopathic Pulmonary Fibrosis (IPF) - Results From the Empire Registry

J Kamm, M J Studnicka, J Gregor, P Ovesna et autres

Abstract Rationale Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease. Three trajectories of the clinical course of IPF (rapid, slow and non-progressing) have been described and associated with duration of symptoms. This was observed for 114 IPF patients and has not …

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Statin use and its implications on survival and disease progression in the European MultiPartner idiopathic pulmonary fibrosis registry (EMPIRE)

David Lang, Bernd Lamprecht, Nesrin Moğulkoç, M Sterclova et autres

Background and objectives While recent data imply an association of statin use with improved prognosis in idiopathic pulmonary fibrosis (IPF), older reports suggested an increased risk of interstitial lung diseases development. We investigated the association of statin medication with survival and disease …

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Lung Transplantation in Idiopathic Pulmonary Fibrosis Patients in the European MultiPartner IPF Registry: Challenges for Health Equity

Nóra Melinda Tóth, Mordechai Reuven Kramer, Martina Šterclová, Veronika Müller et autres

Background: Despite advancements in pharmacological therapy, lung transplantation (LuTX) remains the only life-prolonging treatment in end-stage idiopathic pulmonary fibrosis (IPF). However, real-world referral patterns in Central and Eastern European (CEE) countries remain poorly characterized. We aimed to comprehensively review factors influencing referral …

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AI-Assisted Simple Scoring Algorithm Was Helpful in the Risk Assessment of Cardiac Involvement in Patients with Pulmonary Sarcoidosis

Małgorzata Dybowska, Witold Zbyszek Tomkowski, Katarzyna B. Lewandowska, Dorota Piotrowska‐Kownacka et autres

Background: Cardiac involvement, one of the most life-threatening complications of sarcoidosis, remains under-recognized due to its oligo-symptomatic presentation in some patients. This retrospective study aimed to evaluate the utility of various clinical predictors of cardiac sarcoidosis (CS) development. Methods: The study included …

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Real-world treatment persistence and predictive factors for discontinuation of antifibrotic therapies in patients with idiopathic pulmonary fibrosis: a post-hoc analysis of two multicenter observational cohort studies in Poland

Sebastian Majewski, Katarzyna Górska, Katarzyna B. Lewandowska, Magdalena Maria Martusewicz-Boros et autres

Background: Persistence with antifibrotic medications in patients with idiopathic pulmonary fibrosis (IPF) is crucial for long-term outcomes. However, real-world data regarding treatment persistence patterns in IPF are scarce. Methods: analysis of two retrospective, real-world, multicenter observational studies (PolExPIR and PolExNIB) that collected …

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Assessment of lung function and severity grading in interstitial lung diseases (% predicted versus z-scores) and association with survival: A retrospective cohort study of 6,808 patients

Piotr W. Boros, Magdalena Maria Martusewicz-Boros, Katarzyna B. Lewandowska

BACKGROUND: Pulmonary function tests (PFTs) are essential for predicting outcomes in interstitial lung disease (ILD). In 2022, an expert panel recommended using z-scores instead of the traditional % predicted cut-off values to interpret the severity of PFT abnormalities which may lead to …

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MUC5B Polymorphism in Patients with Idiopathic Pulmonary Fibrosis—Does It Really Matter?

Katarzyna B. Lewandowska, Urszula Lechowicz, Adriana Roży, Maria Falis et autres

Idiopathic pulmonary fibrosis (IPF) is a rare disorder concerning elderly people, predominantly men, active or former smokers, with a progressive nature and leading to premature mortality. The cause of the disease is unknown. However, there are some risk factors, among which genetic …

Acute Respiratory Failure as the First Sign of Non-Fibrotic Hypersensitivity Pneumonitis – Diagnostic and Therapeutic Challenges

Katarzyna B. Lewandowska, Lucyna Opoka, Iwona Bartoszuk, Małgorzata Ewa Jędrych et autres

Background. Hypersensitivity pneumonitis (HP) is an increasingly recognized interstitial lung disease, developing as a result of exposition to inhaled, mostly organic, antigens. Two types of the disease are presently distinguished based on HRCT pattern and/or lung biopsy: fibrotic and non-fibrotic (non-fHP). Complete …

Statin use and its implications on survival and disease progression in the European MultiPartner Idiopathic Pulmonary Fibrosis Registry (EMPIRE)

David Lang, Bernd Lamprecht, Nesrin Moğulkoç, Martina Šterclová et autres

Background: Published data suggest an association of statin use with a lower incidence of idiopathic pulmonary fibrosis (IPF), and with improved prognosis in established IPF. Objectives: We aimed to evaluate these interactions in patients included in the European MultiPartner IPF Registry (EMPIRE). …

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Short- and long-term clinical outcomes of nintedanib therapy in IPF patients with different phenotypes: A retrospective registry-based study

Martina Koziar Vašáková, Jakub Gregor, Nesrin Moğulkoç, Mordechai Rehuven Kramer et autres

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Does a Type of Inciting Antigen Correlate with the Presence of Lung Fibrosis in Patients with Hypersensitivity Pneumonitis?

Kamila Deutsch, Katarzyna B. Lewandowska, Agata Kowalik, Iwona Bartoszuk et autres

Introduction: Hypersensitivity pneumonitis (HP) is an interstitial inflammatory lung disease that develops as a result of exposition to various, mostly organic antigens. In some patients, fibrotic HP is diagnosed. Factors predisposing to the development of fibrotic lung disease in HP patients are …

Ovarian Stem Cells for Women’s Infertility: State of the Art

Krzysztof Grettka, Katarzyna Idzik, Katarzyna B. Lewandowska, Ksena Świętek et autres

Today, women's infertility is considered a social disease in females, occurring not only as an effect of POF (premature ovarian failure) but also as CTRI (cancer treatment-related infertility) in oncologic patients. Several procedures for FP (fertility preservation) are currently adopted to prevent …

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