Zexian Ou

CK-666 protects against ferroptosis and renal ischemia-reperfusion injury through a microfilament-independent mechanism

Qian Hu, Yanan Zhao, Wan‐Yang Sun, Zexian Ou et autres

Ferroptosis is a type of regulated cell death driven by iron-dependent accumulation of lipid peroxidation, exhibiting unique morphological changes. While actin microfilaments are crucial for various cellular processes, including morphogenesis, motility, endocytosis, and cell death, their role in ferroptosis remains unclear. Here, …

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A New Chinese Event Detection Method based on PMTNet

Xiaohua Ke, Zexian Ou, Xiaobo Wu, Binglong Li

Event detection is the key to improve the accuracy of information extraction task. However, the identification model of trigger words is often interfered by text ambiguity and redundant information. This paper focuses on accurately identifying trigger words to improve the accuracy of …

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Silibinin Inhibits Cell Ferroptosis and Ferroptosis-Related Tissue Injuries

Wentao Duan, Zexian Ou, Yuxing Huang, Yifan Zhang et autres

Ferroptosis is involved in various tissue injuries including neurodegeneration, ischemia-reperfusion injury, and acute liver injury. Ferroptosis inhibitors exhibit promising clinical potential in the treatment of various diseases. As a traditional chemical, silymarin has been widely used in healthcare and clinical applications to …

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CK-666 protects against ferroptosis and renal ischemia-reperfusion injury through a microfilament-independent mechanism

Qian Hu, Wan‐Yang Sun, Zexian Ou, Wentao Duan et autres

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A hierarchical system of covalent and dual non-covalent crosslinks promotes the toughness and self-healing properties of polymer hydrogels

Yinlei Lin, Zexian Ou, Shuoqi Wang, Sheng Sun et autres

, a strong self-healing ability achieved at ambient temperature without the need for any stimulus or healing agent). The multiple crosslinks developed in this study for one polymer hydrogel network are significant steps to construct the desired functional hydrogels with excellent self-healing …

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GPX4 and vitamin E cooperatively protect hematopoietic stem and progenitor cells from lipid peroxidation and ferroptosis

Qian Hu, Yifan Zhang, Huiling Lou, Zexian Ou et autres

Ferroptosis, a newly defined mode of regulated cell death caused by unbalanced lipid redox metabolism, is implicated in various tissue injuries and tumorigenesis. However, the role of ferroptosis in stem cells has not yet been investigated. Glutathione peroxidase 4 (GPX4) is a …

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