Priya Pai

Immune mechanisms and pathophysiology of T cell-mediated pediatric acute liver failure (TC-PALF)

Jason T. C. Lee, Harry Sutton, Priya Pai, Arianna Barbetta et autres

Immune dysregulation in pediatric acute liver failure (PALF) is a distinct phenomenon that has garnered interest with respect to disease outcomes and targeted therapies. Some patients with PALF have an "indeterminate" (iPALF) etiology ranging from acute severe hepatitis to fulminant liver failure. …

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S1011 Feasibility of Non-Operative Management Following Neoadjuvant Immune Checkpoint Inhibitors in Resectable dMMR/MSI-H Gastroesophageal Adenocarcinoma

Fares Jamal, Oudai Sahwan, Cody Eslinger, Shaylene A. McCue et autres

Introduction: Neoadjuvant immune checkpoint inhibitors (nICIs) have demonstrated high response rates in patients with deficient mismatch repair (dMMR)/microsatellite instability-high (MSI-H) gastroesophageal adenocarcinoma (GEA). The NEONIPIGA and INFINITY trials reported promising rates of pathological complete response (pCR), with early data suggesting non-operative management …

Data from HOXA5-Mediated Stabilization of IκBα Inhibits the NF-κB Pathway and Suppresses Malignant Transformation of Breast Epithelial Cells

Priya Pai, Guannan Wang, Wei Wen Teo, Diana Raez-Rodriguez et autres

Abstract HOXA5 is a transcription factor and tumor suppressor that promotes differentiation of breast epithelial cells and is frequently lost during malignant transformation. HOXA5 loss alone, however, does not confer tumorigenicity. To determine which molecular alterations combined with loss of HOXA5 expression …

Supplementary Data from HOXA5-Mediated Stabilization of IκBα Inhibits the NF-κB Pathway and Suppresses Malignant Transformation of Breast Epithelial Cells

Priya Pai, Guannan Wang, Wei Wen Teo, Diana Raez-Rodriguez et autres

Supplementary Data from HOXA5-Mediated Stabilization of IκBα Inhibits the NF-κB Pathway and Suppresses Malignant Transformation of Breast Epithelial Cells

Supplementary Data from HOXA5-Mediated Stabilization of IκBα Inhibits the NF-κB Pathway and Suppresses Malignant Transformation of Breast Epithelial Cells

Priya Pai, Guannan Wang, Wei Wen Teo, Diana Raez-Rodriguez et autres

Supplementary Data from HOXA5-Mediated Stabilization of IκBα Inhibits the NF-κB Pathway and Suppresses Malignant Transformation of Breast Epithelial Cells

Supplementary Data from HOXA5-Mediated Stabilization of IκBα Inhibits the NF-κB Pathway and Suppresses Malignant Transformation of Breast Epithelial Cells

Priya Pai, Guannan Wang, Wei Wen Teo, Diana Raez-Rodriguez et autres

Supplementary Data from HOXA5-Mediated Stabilization of IκBα Inhibits the NF-κB Pathway and Suppresses Malignant Transformation of Breast Epithelial Cells

Supplementary Data from HOXA5-Mediated Stabilization of IκBα Inhibits the NF-κB Pathway and Suppresses Malignant Transformation of Breast Epithelial Cells

Priya Pai, Guannan Wang, Wei Wen Teo, Diana Raez-Rodriguez et autres

Supplementary Data from HOXA5-Mediated Stabilization of IκBα Inhibits the NF-κB Pathway and Suppresses Malignant Transformation of Breast Epithelial Cells

Data from HOXA5-Mediated Stabilization of IκBα Inhibits the NF-κB Pathway and Suppresses Malignant Transformation of Breast Epithelial Cells

Priya Pai, Guannan Wang, Wei Wen Teo, Diana Raez-Rodriguez et autres

Abstract HOXA5 is a transcription factor and tumor suppressor that promotes differentiation of breast epithelial cells and is frequently lost during malignant transformation. HOXA5 loss alone, however, does not confer tumorigenicity. To determine which molecular alterations combined with loss of HOXA5 expression …

HOXA5-Mediated Stabilization of IκBα Inhibits the NF-κB Pathway and Suppresses Malignant Transformation of Breast Epithelial Cells

Priya Pai, Guannan Wang, Wei Wen Teo, Diana Raez-Rodriguez et autres

HOXA5 is a transcription factor and tumor suppressor that promotes differentiation of breast epithelial cells and is frequently lost during malignant transformation. HOXA5 loss alone, however, does not confer tumorigenicity. To determine which molecular alterations combined with loss of HOXA5 expression can …

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Intraductal administration of transferrin receptor-targeted immunotoxin clears ductal carcinoma in situ in mouse models of breast cancer—a preclinical study

Guannan Wang, Alok Kumar, Wanjun Ding, Preethi C. Korangath et autres

The human transferrin receptor (TFR) is overexpressed in most breast cancers, including preneoplastic ductal carcinoma in situ (DCIS). HB21(Fv)-PE40 is a single-chain immunotoxin (IT) engineered by fusing the variable region of a monoclonal antibody (HB21) against a TFR with a 40 kDa …

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Depletion of transmembrane mucin 4 (Muc4) alters intestinal homeostasis in a genetically engineered mouse model of colorectal cancer

Ramesh Pothuraju, Priya Pai, Sanjib Chaudhary, Jawed Akhtar Siddiqui et autres

Aging | doi:10.18632/aging.203935. Ramesh Pothuraju, Priya Pai, Sanjib Chaudhary, Jawed A. Siddiqui, Jesse L. Cox, Sukhwinder Kaur, Satyanarayana Rachagani, Hemant K. Roy, Michael Bouvet, Surinder K. Batra

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Abstract P5-08-03: Intraductal administration of a Transferrin Receptor-directed immunotoxin eliminates ductal carcinoma in situ in preclinical mammary in-duct (MIND) models of breast cancer

Saraswati Sukumar, Guannan Wang, Alok Kumar, Wanjun Ding et autres

Abstract Background: Increased detection of ductal carcinoma in situ (DCIS) has been a consequence of mammographic screening. Currently there is a reappraisal of the necessity of aggressive treatment, with their attendant toxicities for a preneoplastic lesion with 15-20% chance of recurrence or …

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