Immune mechanisms and pathophysiology of T cell-mediated pediatric acute liver failure (TC-PALF)
Rattachement africain : us, ca. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Immune dysregulation in pediatric acute liver failure (PALF) is a distinct phenomenon that has garnered interest with respect to disease outcomes and targeted therapies. Some patients with PALF have an "indeterminate" (iPALF) etiology ranging from acute severe hepatitis to fulminant liver failure. Recent evidence from iPALF demonstrates that a large subset suffers from a unified, immune-mediated disorder. This immune-mediated PALF has been defined by the presence of dense T-cell infiltrates on liver biopsy and is often referred to as T-cell PALF (TC-PALF). TC-PALF has common features with other inflammatory liver diseases, including autoimmune hepatitis, hemophagocytic lymphohistiocytosis, and macrophage activation syndrome, while also demonstrating distinct pathologic features that contribute to liver injury in PALF. In this review, the spectrum of disease, comparisons between young and aged liver immune microenvironments, and the current literature evaluating the immune system during PALF are summarized. Relationships between TC-PALF, other inflammatory liver diseases, and contemporary studies that associate specific immune subsets with this pathology are also reviewed. These studies use precision "omic" technologies to investigate tissue and blood samples in TC-PALF and have opened new lines of investigation into potential genetic, immunologic, and environmental risk factors for disease. Together, recent data suggest that immune dysregulation is a central feature of TC-PALF, and facets of disease offer potential biomarker identification to aid in the clinical management of TC-PALF.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Immune mechanisms and pathophysiology of T cell-mediated pediatric acute liver failure (TC-PALF)
- Date Crossref
- 20/08/2026
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Southern California pays non établi dans la noticeUniversité ou école supérieure
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Children's Hospital of Los Angeles pays non établi dans la noticeOrganisme public
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University of Toronto Department of Immunology pays non établi dans la noticeUniversité ou école supérieure
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University of Rochester Department of Surgery pays non établi dans la noticeUniversité ou école supérieure
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Keck School of Medicine Department of Surgery pays non établi dans la noticeUniversité ou école supérieure
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Children’s Hospital Los Angeles Hepatology and Nutrition pays non établi dans la noticeÉtablissement de santé
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Department of Pathology and Laboratory Medicine pays non établi dans la noticeStructure de recherche
University of Southern California, Children's Hospital of Los Angeles et Department of Immunology — University of Toronto, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.