Mizuki Nagata

Wnt-dependent ontogeny of acellular cementum-forming cementoblasts on the tooth root surface

Taishi Komori, Mizuki Nagata, Natnicha Praneetpong, Hanwen Fan et autres

Abstract Cementum is a specialized mineralized tissue that covers the tooth root surface and anchors the tooth to the surrounding periodontal ligament. The cervical acellular cementum (AC) is indispensable for periodontal attachment and represents a key target for periodontal regenerative therapies. However, …

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女子大学生における歯肉炎の有無および クロノタイプの違いと食事摂取状況の関連

Tomomi Ichikawa, Mizuki Nagata

This study aimed to examine the association between the presence of gingivitis and differences in chronotype with dietary intake and breakfast consumption frequency among female university students. The participants were 27 female university students. A self-administered questionnaire was used to assess oral …

Stem-cell regulation in periodontium formation and regeneration

Mizuki Nagata, Chika Nagaoka, Takanori Iwata

INTRODUCTION: The periodontium is a dynamic composite tissue that anchors teeth to the alveolar bone and adapts continuously to mechanical loading and inflammatory challenges throughout life. Its development, homeostasis, and regeneration depend on diverse mesenchymal stem and progenitor cell populations derived from …

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A Hedgehog–Foxf axis coordinates dental follicle-derived alveolar bone formation

Mizuki Nagata, Gaurav T. Gadhvi, Taishi Komori, Yuki Arai et autres

The alveolar bone supports the tooth’s lifelong functionality. Here, the authors identify a tooth-specific mechanism of bone formation in which the Hedgehog–Foxf pathway regulates the alveolar bone osteoblast fates of DF progenitor cells.

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Wnt-directed CXCL12-expressing apical papilla progenitor cells drive tooth root formation

Mizuki Nagata, Gaurav T. Gadhvi, Taishi Komori, Yuki Arai et autres

The tooth root is a critical component of the tooth. Here they identify root-forming CXCL12+ apical papilla progenitor cells that provide odontoblasts and cementoblasts in a Wnt-dependent manner, with plasticity to form alveolar bone osteoblasts during regeneration.

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Control of alveolar bone development, homeostasis, and socket healing by salt-inducible kinases

Nicha Tokavanich, Byron Chan, Katelyn Strauss, Christian D. Castro et autres

Alveolar bone supports and anchors teeth. The parathyroid hormone-related protein (PTHrP) pathway plays a key role in alveolar bone biology. Salt-inducible kinases (SIKs) are important downstream regulators of PTH/PTHrP signaling in the appendicular skeleton, where SIK inhibition increases bone formation and trabecular …

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Exploring the in vivo identity of mesenchymal stem cells in periodontal development and regeneration

Mizuki Nagata, Takanori Iwata

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Control of alveolar bone development, homeostasis, and socket healing by salt inducible kinases

Nicha Tokavanich, Byron Chan, Katelyn Strauss, Christian D. Castro et autres

Alveolar bone supports and anchors teeth. The parathyroid hormone-related protein (PTHrP) pathway plays a key role in alveolar bone biology. Salt inducible kinases (SIKs) are important downstream regulators of PTH/PTHrP signaling in the appendicular skeleton where SIK inhibition increases bone formation and …

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Etiological Mechanisms and Genetic/Biological Modulation Related to PTH1R in Primary Failure of Tooth Eruption

Xiao-xia Li, Man-ting Wang, Zhifang Wu, Qiang Sun et autres

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Hes1 marks peri-condensation mesenchymal cells that generate both chondrocytes and perichondrial cells in early bone development

Yuki Matsushita, Hiroaki Manabe, Takahiro Ohyama, Shogo Nakamura et autres

Bone development starts with condensations of undifferentiated mesenchymal cells that set a framework for future bones within the primordium. In the endochondral pathway, mesenchymal cells inside the condensation differentiate into chondrocytes and perichondrial cells in a SOX9-dependent mechanism. However, the identity of …

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Bone marrow endosteal stem cells dictate active osteogenesis and aggressive tumorigenesis

Yuki Matsushita, Jialin Liu, Angel Ka Yan Chu, Chiaki Tsutsumi‐Arai et autres

Abstract The bone marrow contains various populations of skeletal stem cells (SSCs) in the stromal compartment, which are important regulators of bone formation. It is well-described that leptin receptor (LepR) + perivascular stromal cells provide a major source of bone-forming osteoblasts in …

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The fate of early perichondrial cells in developing bones

Yuki Matsushita, Angel Ka Yan Chu, Chiaki Tsutsumi‐Arai, Shion Orikasa et autres

Abstract In endochondral bone development, bone-forming osteoblasts and bone marrow stromal cells have dual origins in the fetal cartilage and its surrounding perichondrium. However, how early perichondrial cells distinctively contribute to developing bones remain unidentified. Here we show using in vivo cell-lineage …

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