Byung‐Ho Rhie

EGFR inhibitor suppresses tumor growth by blocking lipid uptake and cholesterol synthesis in non-small cell lung cancer

Byung‐Ho Rhie, Sang Hyeon Woo, Hyun‐Yi Kim, Janardhan Keshav Karapurkar et autres

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Tho2‐mediated escort of Nrd1 regulates the expression of aging‐related genes

Yan Liu, J.Y. Park, Suji Lim, Ruxin Duan et autres

The relationship between aging and RNA biogenesis and trafficking is attracting growing interest, yet the precise mechanisms are unknown. The THO complex is crucial for mRNA cotranscriptional maturation and export. Herein, we report that the THO complex is closely linked to the …

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AX-0085, a novel AXL kinase inhibitor, and effects on osimertinib-resistance in non–small-cell lung cancer.

Myeong Jun Choi, Byung‐Ho Rhie, SangHyeon Woo, Si-Eun Yun et autres

e15121 Background: Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) having high efficacy in treating patients with advanced non-small cell lung cancer (NSCLC) with EGFR activating mutations and EGFR T70M mutations. Although, osimertinib is a frontline anticancer …

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Sus1 maintains a normal lifespan through regulation of TREX-2 complex-mediated mRNA export

Suji Lim, Yan Liu, Byung‐Ho Rhie, Chun Kim et autres

Eukaryotic gene expression requires multiple cellular events, including transcription and RNA processing and transport. Sus1, a common subunit in both the Spt-Ada-Gcn5 acetyltransferase (SAGA) and transcription and export complex-2 (TREX-2) complexes, is a key factor in coupling transcription activation to mRNA nuclear …

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Sus1 maintains a normal lifespan through regulation of TREX-2 complex-mediated mRNA export

Suji Lim, Yan Liu, Byung‐Ho Rhie, Chun Kim et autres

Abstract Eukaryotic gene expression requires multiple cellular events, including transcription and RNA processing and transport. Sus1, a common subunit in both the Spt-Ada-Gcn5 acetyltransferase (SAGA) and transcription and export complex-2 (TREX-2) complexes, is a key factor in coupling transcription activation to mRNA …

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Ubiquitin-Specific Protease 3 Deubiquitinates and Stabilizes Oct4 Protein in Human Embryonic Stem Cells

Byung‐Ho Rhie, Ainsley Mike Antao, Janardhan Keshav Karapurkar, Min-Seong Kim et autres

Oct4 is an important mammalian POU family transcription factor expressed by early human embryonic stem cells (hESCs). The precise level of Oct4 governs the pluripotency and fate determination of hESCs. Several post-translational modifications (PTMs) of Oct4 including phosphorylation, ubiquitination, and SUMOylation have …

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Loss of the Set2 histone methyltransferase increases cellular lifespan in yeast cells

Hong‐Yeoul Ryu, Byung‐Ho Rhie, S. Ahn

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The RNA polymerase II Rpb4/7 subcomplex regulates cellular lifespan through an mRNA decay process

Ruxin Duan, Byung‐Ho Rhie, Hong‐Yeoul Ryu, S. Ahn

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Cellular aging is associated with increased ubiquitylation of histone H2B in yeast telomeric heterochromatin

Byung‐Ho Rhie, Young-Ha Song, Hong‐Yeoul Ryu, S. Ahn

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