Michael W. McBurney

Resveratrol Inhibits Neointimal Growth after Arterial Injury in High-Fat-Fed Rodents: The Roles of SIRT1 and AMPK

June Guo, Troy J. Pereira, Yusaku Mori, Marel Gonzalez Medina et autres

We have shown that both insulin and resveratrol (RSV) decrease neointimal hyperplasia in chow-fed rodents via mechanisms that are in part overlapping and involve the activation of endothelial nitric oxide synthase (eNOS). However, this vasculoprotective effect of insulin is abolished in high-fat-fed …

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Supplementary Material for: Resveratrol Inhibits Neointimal Growth after Arterial Injury in High-Fat-Fed Rodents: The Roles of SIRT1 and AMPK

Jindong Guo, Troy J. Pereira, Yusaku Mori, Mónica Gonzalez‐Medina et autres

We have shown that both insulin and resveratrol (RSV) decrease neointimal hyperplasia in chow-fed rodents via mechanisms that are in part overlapping and involve the activation of endothelial nitric oxide synthase (eNOS). However, this vasculoprotective effect of insulin is abolished in high-fat-fed …

Unconventional Secretion of Adipocyte Fatty Acid Binding Protein 4 Is Mediated By Autophagic Proteins in a Sirtuin-1–Dependent Manner

Ajeetha Josephrajan, Ann V. Hertzel, Ellie K. Bohm, Michael W. McBurney et autres

Fatty acid binding protein 4 (FABP4) is a leaderless lipid carrier protein primarily expressed by adipocytes and macrophages that not only functions intracellularly but is also secreted. The secretion is mediated via unconventional mechanism(s), and in a variety of species, metabolic dysfunction …

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Ablation of Sirtuin 1 Deacetylase Activity Induces Pulmonary Emphysema by Inducing Cellular Senescence and Disrupting Circadian Clock in Mice (P01-022-19)

Xiangdong Wang, Kang‐Quan Hu, Liu Chun, Michael W. McBurney

Sirtuin 1 (SIRT1), a NAD+-dependent protein/histone deacetylase has the capability to extend life span, delay aging, and prevent aging-related diseases. There are several reports showing that there is no significant decline in SIRT1 protein with age, indicating that SIRT1 protein levels alone …

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IL-15 improves skeletal muscle oxidative metabolism and glucose uptake in association with increased respiratory chain supercomplex formation and AMPK pathway activation

Lucien Nadeau, David A. Patten, Audrey Caron, Léa Garneau et autres

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Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade

Joy Hsu, Jonathan J. Hodgins, Malvika Marathe, Chris J. Nicolai et autres

Checkpoint blockade immunotherapy targeting the PD-1/PD-L1 inhibitory axis has produced remarkable results in the treatment of several types of cancer. Whereas cytotoxic T cells are known to provide important antitumor effects during checkpoint blockade, certain cancers with low MHC expression are responsive …

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Modulating SIRT1 activity variously affects thymic lymphoma development in mice

Katherine V. Clark-Knowles, Danielle Dewar‐Darch, Karen Jardine, Josée Coulombe et autres

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Food anticipatory activity on a calorie-restricted diet is independent of Sirt1

Dina R. Assali, Cynthia T. Hsu, Keith M. Gunapala, Antonio Aguayo et autres

A number of studies have demonstrated that the Sirtuin family member, Sirt1, is a key integrator of growth, metabolism, and lifespan. Sirt1 directly interacts with and deacetylates key regulators of the circadian clock, positioning it to be an important link between feeding …

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Methionine metabolism is essential for SIRT1‐regulated mouse embryonic stem cell maintenance and embryonic development

Shuang Tang, Yi Fang, Gang Huang, Xiaojiang Xu et autres

Methionine metabolism is critical for epigenetic maintenance, redox homeostasis, and animal development. However, the regulation of methionine metabolism remains unclear. Here, we provide evidence that SIRT1, the most conserved mammalian NAD+‐dependent protein deacetylase, is critically involved in modulating methionine metabolism, thereby impacting …

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Ablation of systemic SIRT1 activity promotes nonalcoholic fatty liver disease by affecting liver-mesenteric adipose tissue fatty acid mobilization

Junrui Cheng, Chun Liu, Kang‐Quan Hu, Andrew S. Greenberg et autres

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Ablation of systemic SIRT1 activity promotes nonalcoholic fatty liver disease by affecting liver‐mesenteric adipose tissue fatty acid mobilization

Junrui Cheng, Chun Liu, Kang‐Quan Hu, Andrew S. Greenberg et autres

The incidence of nonalcoholic fatty liver disease (NAFLD) is escalating paralleled with obesity rates in both adults and children. Mammalian sirtuin 1 (SIRT1), a highly conserved NAD + ‐dependent protein deacetylase, has been identified as a metabolic regulator of lipid homeostasis and …

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Reversible modulation of SIRT1 activity in a mouse strain

Katherine V. Clark-Knowles, Xiaohong He, Karen Jardine, Josée Coulombe et autres

The SIRT1 protein deacetylase is reported to have a remarkably wide spectrum of biological functions affecting such varied processes as aging, cancer, metabolism, neurodegeneration and immunity. However, the SIRT1 literature is also full of contradictions. To help establish the role(s) of SIRT1 …

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