Aaron S. Abramovitz

Recombinant Vesicular Stomatitis Virus Vectors Expressing Herpes Simplex Virus Type 2 gD Elicit Robust CD4+Th1 Immune Responses and Are Protective in Mouse and Guinea Pig Models of Vaginal Challenge

Robert J. Natuk, David A. Cooper, Min Guo, Priscilla Calderon et autres

Recombinant vesicular stomatitis virus (rVSV) vectors offer an attractive approach for the induction of robust cellular and humoral immune responses directed against human pathogen target antigens. We evaluated rVSV vectors expressing full-length glycoprotein D (gD) from herpes simplex virus type 2 (HSV-2) …

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An efficient helper-virus-free method for rescue of recombinant paramyxoviruses and rhadoviruses from a cell line suitable for vaccine development

Susan E. Witko, Cheryl S. Kotash, Rebecca M. Nowak, J. Erik Johnson et autres

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Th1Th2-like immunity and resistance to herpes simplex labialis

Spotswood L. Spruance, Thomas G. Evans, Mark B. McKeough, Louise Thai et autres

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Baculovirus-expressed herpes simplex virus type 2 glycoprotein D is immunogenic and protective against lethal HSV challenge

Victoria A. Landolfi, C D Zarley, Aaron S. Abramovitz, Nelvis Figueroa et autres

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Native herpes simplex virus glycoprotein D vaccine: immunogenicity and protection in animal models

Eric M. Mishkin, John V. Fahey, Yoichiro Kino, Ronald Klein et autres

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The bovine lens neutral proteinase comprises a family of cysteine-dependent proteolytic activities

B.J. Wagner, Joyce W. Margolis, Aaron S. Abramovitz

Inhibitor studies with peptide substrates demonstrate that bovine lens neutral proteinase comprises three distinct activities. Diisopropylfluorophosphate distinguishes the activity hydrolyzing carbobenzoxy-Gly-Gly-Leu-p-nitroanilide (inhibited) from that hydrolyzing carbobenzoxy-Leu-Leu-Glu-2-naphthylamide (not inhibited). Leupeptin inhibits hydrolysis of the substrate carbobenzoxy-Leu-Leu-Arg-2-naphthylamide, but not hydrolysis of carbobenzoxy-Gly-Gly-Leu-p-nitroanilide or carbobenzoxy-Leu-Leu-Glu-2-naphthylamide, …

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Lens neutral proteinase preparations hydrolyze glutamoyl bonds

B.J. Wagner, Joyce W. Margolis, S.-C.J. Fu, Aaron S. Abramovitz

Differential inhibition of two proteolytic activities in bovine lens neutral-proteinase preparations

B.J. Wagner, Joyce W. Margolis, Aaron S. Abramovitz, S.-C.J. Fu

Hydrolysis of carbobenzoxy-Leu-Leu-Glu 2-naphthylamide by bovine lens neutral-proteinase preparations is not affected by the esterase inhibitor di-isopropyl fluorophosphate, whereas hydrolysis of carbobenzoxy-Gly-Gly-Leu p-nitroanilide is completely inhibited. Hydrolysis of alpha-crystallin, a lens structural protein, can be inhibited by only 50% after prolonged treatment …

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Recovery of Native Proteins from Preparative Electrophoresis Gel Slices by Reverse Polarity ElutioN

Aaron S. Abramovitz, Verrell M. Randolph, Aruna S. Mehra, Sylvia Chn'stakos

A technique for high yield recovery of native, biologically active proteins from preparative polyacrylamide gel slices by reverse polarity elution is described. No apparatus other than the standard slab gel electrophoresis system is required. Several proteins have been recovered in biologically active …

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Inhibition of superoxide production in human neutrophils by purified soybean polypeptides. Re-evaluation of the involvement of proteases.

Aaron S. Abramovitz, Jonathan Yavelow, Verrell M. Randolph, Walter Troll

Inhibition of neutrophil superoxide production has been previously reported for reagents and polypeptides which also inhibit serine proteases. There are disagreements between the results of different laboratories including our own, which have attempted to use the Kunitz soybean trypsin inhibitor to block …

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Pseudo-inhibitors of neutrophil superoxide production: Evidence that soybean-derived polypeptides are superoxide dismutases

Aaron S. Abramovitz, Jun-Yan Hong, Verrell M. Randolph

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Activation of C3 via the alternative complement pathway results in fixation of C3b to the pneumococcal cell wall.

J A Winkelstein, Aaron S. Abramovitz, Alexander Tomasz

Abstract The present study was performed in order to determine the identity of the pneumococcal surface structure to which C3b binds when it has been activated via the alternative pathway. The binding of C3b was assessed by incubating the desired pneumococcal strain …

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