Sharon Harrison

Assessing the impact of cardiovascular disease and ADT on survival disparities in prostate cancer.

Camille Ragin, Karen J Ruth, Zhongxuan He, Eric M. Horwitz et autres

268 Background: US Black men are on average diagnosed with more aggressive prostate cancer (PCa) and have higher mortality than White men. Studies in predominantly White populations show that PCa patients with pre-existing cardiovascular disease (CVD), metabolic syndrome (MetS), or prior CVD …

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How Does Marijuana Legislation Affect Crime? Medical and Recreational Laws Across 50 States

Sharon Harrison, Loran Chollete, Ching-Chih Lu, Khawaja Mamun

Novel policies often have unintended consequences—programs that legalize one crime may affect other crimes. Marijuana legalization is an example of such spillovers, as states have legalized use in a staggered fashion. While previous research focuses on a few states or one type …

How Does Marijuana Legislation Affect Crime? Medical and Recreational Laws Across 50 States

Sharon Harrison, Loran Chollete, Ching-Chih Lu, Khawaja Mamun

Novel policies often have unintended consequences—programs that legalize one crime may affect other crimes. Marijuana legalization is an example of such spillovers, as states have legalized use in a staggered fashion. While previous research focuses on a few states or one type …

AI/ML-Assisted Detection of HMGA2 RNA Isoforms in Prostate Cancer Patient Tissue

Bor-Jang Hwang, Oluwatunmise Akinniyi, Sharon Harrison, Denise Y. Gibbs et autres

RNA In Situ Hybridization (RISH) is a powerful tool for spatial gene expression analysis, yet its quantitative use remains limited by the high cost and inaccessibility of commercial software, particularly in under-resourced settings. This study developed an Artificial Intelligence/Machine Learning (AI/ML)-assisted RISH …

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Abstract C118: AI/ML-assisted detection of HMGA2 RNA isoforms in prostate cancer patient tissue

Bor-Jang Hwang, Oluwatunmise Akinniyi, Sharon Harrison, Charles G. Waihenya et autres

Abstract RNA In Situ Hybridization (RISH) is a powerful tool to analyze RNA expression spatially within cells and tissues. However, tools to quantify this technology is not readily available due to high cost of the software available to under-resourced communities. We therefore …

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Abstract 3630: First-line therapies and subjective cognitive function trajectories among international metastatic hormone-sensitive prostate cancer survivors

Michelle O. Sodipo, Alicia Katherine Morgans, Erica T. Warner, Emily M. Rencsok et autres

Abstract Introduction: The standard of care for metastatic hormone-sensitive prostate cancer (mHSPC) has evolved with the expanded approval of androgen receptor pathway inhibitors (ARPIs) alongside androgen deprivation therapy (ADT). ADT alone has been shown to affect cognitive function. However, the cognitive impact …

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Exploring quality of life impact on cancer screening in Black subgroups

Kimlin Tam Ashing, Elizabeth L. Blackman, Gaole Song, Denise Y. Gibbs et autres

BACKGROUND: Black individuals in United States have the poorest outcomes in cancer and receipt of cancer screening. PURPOSES: This study seeks to describe cancer screening among Black subgroups, especially considering the influence on quality of life (QOL). METHODS: Data from the African …

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Complications among assisted reproductive technique (ART) twin gestations versus spontaneously conceived twin gestations (SC): A retrospective outcome analysis among an Afro-Caribbean population at a university-based hospital in Jamaica

Kamali N. Carroll, Tracey Martinborough, Loxley R. Christie, Sharon Harrison et autres

Aim: The aim of the study is to compare the frequency of maternal and neonatal complications among pregnant women with twin pregnancies conceived spontaneously versus conceived by assisted reproductive technique (ART). Methods: Univariate and bivariate analyses of maternal characteristics and neonatal outcomes …

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Abstract LB138: Quality of life impact on cancer screening in Black subgroups

Camille C. Rose Ragin, Kimlin Tam Ashing, Gaole Song, Elizabeth L. Blackman et autres

Abstract Introduction Blacks have the poorest cancer outcomes with the highest incidence and mortality. Preliminary studies led by the African Caribbean Consortium (AC3) show that Blacks are diverse with distinct cancer risks and outcomes. It is clear that cancer screening is critical …

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Abstract 3381: Diversifying the breast cancer cell line repository with ACRJ-BC24, ACRJ-BC24α, and ACRJ-BC24β: Novel TNBC cell lines derived from an Afro-Caribbean patient

Isabella Allen, Shannique Clarke, Jovanka Ravix, Alex P. Sanchez Covarrubias et autres

Abstract Breast cancer is a leading global health burden; however, women of African ancestry are disproportionately affected and have an increased risk of developing more aggressive breast cancer, triple-negative breast cancer (TNBC), and consequently suffering poorer outcomes. One factor contributing to this …

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Data from Expanding the Prostate Cancer Cell Line Repertoire with ACRJ-PC28, an AR-negative Neuroendocrine Cell Line Derived From an African-Caribbean Patient

Henkel Valentine, William Derval Aiken, Belinda F. Morrison, Ziran Zhao et autres

Prostate cancer cell lines from diverse backgrounds are important to addressing disparities in prostate cancer incidence and mortality rates among Black men. ACRJ-PC28 was developed from a transrectal needle biopsy and established via inactivation of the CDKN2A locus and simultaneous expression of …

Supplemental table ST1: Sample collection and culture conditions from Expanding the Prostate Cancer Cell Line Repertoire with ACRJ-PC28, an AR-negative Neuroendocrine Cell Line Derived From an African-Caribbean Patient

Henkel Valentine, William Derval Aiken, Belinda F. Morrison, Ziran Zhao et autres

In these prior attempts, culture conditions such as media, extra-cellular matrices and culture flasks were varied to determine the optimal culture conditions for generation of prostate cancer explants.