Eleonora Nardi

Sphingosine 1-phosphate-driven interplay between neutrophils and endometriotic cells fuels fibrosis in endometriosis: insights into the role of neutrophil extracellular traps

Matteo Prisinzano, Isabelle Seidita, Maria Sofia Bertilacchi, Matilde Giusti et autres

Abstract Background Endometriosis is a chronic disease affecting millions of women worldwide, characterized by the presence of ectopic endometrial-like tissue. While the formation of neutrophil extracellular traps (NETs) has been linked to endometriosis progression, the underlying implicated molecular mechanisms remain poorly understood. …

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Multidisciplinary and Personalized Molecular Diagnosis to Solving Sudden Death During Sport

Andrea Costantino, Óscar Campuzano, Fabio Vaiano, Eleonora Nardi et autres

Sudden cardiac death is the leading cause of death among athletes during exercise. These events are devastating for both the family and society, especially when they occur in children and young adults. Some of these unexpected deceases occur in athletes who carry …

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Abnormal Intrapartum Cardiotocographic Tracing, Fetal Outcome and Placental Pathology

Eleonora Nardi, Simone Grassi, Andrea Costantino, Serena Simeone et autres

Background: Cardiotocography (CTG) represents a cornerstone in modern intrapartum fetal surveillance, allowing continuous assessment of fetal well-being through the analysis of fetal heart rate patterns in relation to uterine contractions. Despite its widespread clinical use, the interpretation of CTG tracings remains complex …

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Green heart: Methylene blue administration in a hemodynamically unstable infant following cardiac arrest due to parental co-sleeping

Eleonora Nardi, Massimo Zedda, Giulio Morettini, Antonio Oliva et autres

We report the autopsy case of a female 10-month-old infant who presented with cardiocirculatory arrest due to hypoxia secondary to compressive asphyxia due parental co-sleeping on the sofa. Despite advanced life support, vasoactive therapy, and rescue administration of methylene blue for refractory …

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Elevated ESR2 and BRCA1 gene expression in adenomyosis associated with endometrial cancer: a pilot study

Francesco La Torre, Eleonora Nardi, Francesca Bonechi, Silvia Vannuccini et autres

Adenomyosis is a benign uterine disease that has been associated with endometrial proliferative disorders. Adenomyosis and endometrial cancer (EC) are sex-steroid-dependent conditions that may coexist, but their estrogen receptor (ER) and progesterone receptor (PR) signaling landscape is poorly defined. The present multicenter …

Elevated ESR2 and BRCA1 gene expression in adenomyosis associated with endometrial cancer: a pilot study

Francesco La Torre, Eleonora Nardi, Francesca Bonechi, Silvia Vannuccini et autres

Background Adenomyosis is a benign uterine disease that has been associated with endometrial proliferative disorders. Adenomyosis and endometrial cancer (EC) are sex-steroid-dependent conditions that may coexist, but their estrogen receptor (ER) and progesterone receptor (PR) signaling landscape is poorly defined.Objective The present …

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Elevated ESR2 and BRCA1 gene expression in adenomyosis associated with endometrial cancer: a pilot study

Francesco La Torre, Eleonora Nardi, Francesca Bonechi, Silvia Vannuccini et autres

Adenomyosis is a benign uterine disease that has been associated with endometrial proliferative disorders. Adenomyosis and endometrial cancer (EC) are sex-steroid-dependent conditions that may coexist, but their estrogen receptor (ER) and progesterone receptor (PR) signaling landscape is poorly defined. The present multicenter …

From trials to the clinic: Real-world experience with mirvetuximab soravtansine in platinum-resistant ovarian cancer and the "Lazarus effect.

Roberta Renda, Cecilia Cerbai, Francesca Castiglione, Maria Cristina Petrella et autres

e17579 Background: Platinum-resistant ovarian cancer (PROC) has limited treatment options, with response rates of 10–15% and median progression-free survival (PFS) of ~ 3.5 months. Mirvetuximab soravtansine (MIRVE), a folate receptor alpha (FRα-)directed antibody-drug conjugate, is the first targeted therapy approved for FRα-positive …

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Retrospective Analysis of 1168 Cases of Ovular Decidual Tissue from First-Trimester Abortions: Proposal for a Histopathological Diagnostic Framework

Eleonora Nardi, Vincenzo Arena

Background: Early pregnancy loss, defined as the spontaneous loss of a pregnancy before 20 weeks of gestation or when the fetus weighs less than 500 g, remains a common obstetric complication, affecting up to 15% of clinically recognized pregnancies. Chromosomal abnormalities, particularly …

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An High-Grade Stromal Sarcoma Localized in the Left Fallopian Tube: A Diagnostically Challenging Case and a Literature Review

Eleonora Nardi

High‑grade stromal sarcoma (HGSS) confined to the fallopian tube has not been clearly documented and may be mis‑classified among other rare tubal sarcomas or malignant mixed Müllerian tumours (MMMT). A systematic search of PubMed, Scopus and Google Scholar (inception to 31 May …

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Adenomyosis is associated with proliferative endometrial disorders

Francesco La Torre, Yannick Hurni, Elisa Farsi, Carlotta Campatelli et autres

OBJECTIVE: To assess the prevalence of proliferative endometrial disorders in women with histologically confirmed adenomyosis and to evaluate the independent association between adenomyosis and each lesion type. DESIGN: Retrospective cohort study. SUBJECTS: Consecutive patients undergoing hysterectomy between January 2021 and August 2024, …

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Molecular and Clinical Profile of a RET-Rearranged Colorectal Cancer With Prolonged Response to Platinum Therapy and Subsequent Targeted Treatment With Selpercatinib

Giovanni Trovato, Michele Basso, Agostino Maria De Rose, Felice Giuliante et autres

RET encodes a receptor tyrosine kinase that activates downstream MAPK, PI3K/AKT, and JNK signaling pathways, contributing to oncogenesis when aberrantly activated.4,5 Selective RET inhibitors, including selpercatinib and pralsetinib, have shown efficacy in RET-driven nonsmall cell lung cancer and thyroid cancer, and emerging …

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