Elevated ESR2 and BRCA1 gene expression in adenomyosis associated with endometrial cancer: a pilot study
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Le résumé fourni par la source
Background Adenomyosis is a benign uterine disease that has been associated with endometrial proliferative disorders. Adenomyosis and endometrial cancer (EC) are sex-steroid-dependent conditions that may coexist, but their estrogen receptor (ER) and progesterone receptor (PR) signaling landscape is poorly defined.Objective The present multicenter study aimed to characterize the expression of estrogen (ESR1/ESR2 plus the coregulators NCOA1, CCND1, BRCA1) and progesterone (PGR plus FOXO1, and CYP26A1) receptor pathway-related genes in hysterectomy specimens of patients with adenomyosis and coexisting EC.Methods Specimens from three groups of patients (n = 10 per group) referred to two tertiary hospitals were studied: adenomyosis plus EC (Group 1), only adenomyosis (Group 2), and only EC (Group 3). Gene expression was assessed by droplet digital PCR using a compartment-matched design. Analysis was compartment-specific, and no cross-compartment comparisons were performed.Results Compared with isolated adenomyosis, adenomyotic lesions from uteri with coexisting EC showed higher ESR2 (p = 0.0082) and BRCA1 (p = 0.0007) expression, with no differences in ESR1, NCOA1, or CCND1. PR-related gene expression (PGR, FOXO1, and CYP26A1) did not differ between adenomyosis groups.Conclusion Although preliminary, the present findings indicate that adenomyosis coexisting with EC is characterized by elevated expression of ESR2 and BRCA1, suggesting an enriched ER-related microenvironment that may be relevant to local estrogen responsiveness.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Elevated ESR2 and BRCA1 gene expression in adenomyosis associated with endometrial cancer: a pilot study
- Date Crossref
- 22/06/2026
- Éditeur
- Informa UK Limited
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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European Society for Sexual Medicine pays non établi dans la noticeOrganisme public
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University of Florence Department of Health Sciences pays non établi dans la noticeUniversité ou école supérieure
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Agostino Gemelli University Polyclinic pays non établi dans la noticeÉtablissement de santé
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Universidade Federal de Minas Gerais Department of Obstetrics and Gynecology pays non établi dans la noticeUniversité ou école supérieure
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Careggi University Hospital Department of Experimental and Clinical Biomedical Sciences “Mario Serio” pays non établi dans la noticeUniversité ou école supérieure
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Fondazione Policlinico Universitario Agostino Gemelli IRCCS Department of Women pays non établi dans la noticeÉtablissement de santé
European Society for Sexual Medicine, Department of Health Sciences — University of Florence et Agostino Gemelli University Polyclinic, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.