Barbara Uzonyi

The human complement factor H-related protein FHR-2 enhances complement activation on host and bacterial ligands

Andrea Schneider, Marcell Cserhalmi, Domonkos Czárán, Dániel Bencze et autres

Regulation of the alternative complement pathway (AP) and that of the amplification loop is important to limit physiological complement activation to the necessary extent on target surfaces, such as microbes or dead cells. Conversely, AP dysregulation contributes to the pathogenesis of various …

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Characterization of disease-associated FHR-5 variants for their ligand binding and complement modulating capacity

Alexandra T. Matola, Dániel Bencze, Dávid Szakács, Marcell Cserhalmi et autres

Factor H-related 5 (FHR-5) belongs to the factor H protein family and plays a role in maintaining the balance of the complement alternative pathway activation and inhibition on host surfaces. Mutations in the CFHR5 gene were linked to eye and kidney diseases. …

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The tumor- and apoptosis-associated annexin A2 is a new ligand for FHL-1 and Factor H-related proteins – annexin-bound FHR-5 enhances alternative pathway activation

Dávid Szakács, Dániel Bencze, Eszter Boros, Patrik Horváth et autres

Annexin A2 (ANXA2) is a membrane-binding protein with diverse intra- and extracellular roles and involvement in certain tumorous and immune processes. Elevated ANXA2 cell-surface levels are characteristic of apoptotic cells where it serves as a ligand for factor H (FH) 1 . …

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Factor H–related proteins and their associated disorders

Mihály Józsi, Barbara Uzonyi

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Development and Characterization of Novel ELISAs for the Specific Quantification of the Factor H-Related Proteins 2, 3, 4, and 5

Mara van Rossum, Bert R.J. Veuskens, Mieke C. Brouwer, Gerard van Mierlo et autres

INTRODUCTION: The complement system's alternative pathway relies on factor H (FH) for immune homeostasis. Next to FH, a group of highly similar proteins was described known as the FH-related (FHR) proteins. The FH protein family includes FH, factor H-like protein 1, and …

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Autoantibodies Against Factor B and Factor H Without Pathogenic Effects in a Patient with Immune Complex-Mediated Membranoproliferative Glomerulonephritis

Alexandra T. Matola, Dorottya Csuka, Ágnes Szilágyi, Michael Rudnicki et autres

Background: Membranoproliferative glomerulonephritis (MPGN) is an umbrella term for chronic disorders affecting the glomeruli. MPGN is often accompanied by the presence of autoantibodies against complement components. However, the actual pathogenic effects of such autoantibodies, if any, are rarely studied. In this work, …

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344 Eculizumab abolishes skin separation in a human ex vivo model of bullous pemphigoid

Simon Vikár, D. Bérczes, Barbara Uzonyi, Mihály Józsi et autres

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The human factor H protein family – an update

Noémi Sándor, Andrea Schneider, Alexandra T. Matola, Veronika H. Barbai et autres

Complement is an ancient and complex network of the immune system and, as such, it plays vital physiological roles, but it is also involved in numerous pathological processes. The proper regulation of the complement system is important to allow its sufficient and …

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230 Interaction of factor H and factor H-related proteins with S and N proteins of SARS-CoV-2

Veronika H. Barbai, Alexandra Papp, Dániel Bencze, Barbara Uzonyi et autres

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180 Functional characterization of monoclonal antibodies against human complement C4 and C4BP

Barbara Uzonyi, Alexandra Papp, Mátka Nagy, József Lázár et autres

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177 Factor H-related proteins bind to extracellular matrix components and affect complement activation

Alexandra Papp, Dániel Bencze, Barbara Uzonyi, Bárbara Márquez‐Tirado et autres

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Autoantibodies against complement factor B in rheumatoid arthritis

Alexandra T. Matola, Angéla Fülöp, Bernadette Rojkovich, György Nagy et autres

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder affecting the joints. Many patients carry anti-citrullinated protein autoantibodies (ACPA). Overactivation of the complement system seems to be part of the pathogenesis of RA, and autoantibodies against the pathway initiators C1q and MBL, …

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