Domonkos Czárán

Time-restricted feeding attenuates allergic dermatitis in mice and is associated with modulation of leptin-driven inflammatory pathways

Zsófia Búr, Bernadett Vendl, Zalán Lumniczky, Domonkos Czárán et autres

ABSTRACT Irregular and unhealthy eating behavior contributes to the development of both metabolic and inflammatory disorders. Time-restricted eating modulates metabolism and immune function without reducing caloric intake, yet its role in inflammatory skin diseases remains unclear. Here, we examined how feeding time …

hu, us (code pays fourni par la source)

The human complement factor H-related protein FHR-2 enhances complement activation on host and bacterial ligands

Andrea Schneider, Marcell Cserhalmi, Domonkos Czárán, Dániel Bencze et autres

Regulation of the alternative complement pathway (AP) and that of the amplification loop is important to limit physiological complement activation to the necessary extent on target surfaces, such as microbes or dead cells. Conversely, AP dysregulation contributes to the pathogenesis of various …

hu (code pays fourni par la source)

ARHGAP25: a novel player in the Pathomechanism of allergic contact hypersensitivity

Domonkos Czárán, Péter Sasvári, Kende Lőrincz, Krisztina Ella et autres

Objective: Contact hypersensitivity (CHS), or allergic contact dermatitis (ACD), is an inflammatory skin disorder characterized by an exaggerated allergic reaction to specific haptens. During this delayed-type allergic reaction, the first contact with the allergen initiates the sensitization phase, forming memory T cells. …

hu (code pays fourni par la source)

Correction: Long COVID syndrome in children: neutrophilic granulocyte dysfunction and its correlation with disease severity

Fanni Kovács, Tamás Posvai, Eszter Zsáry, Ferenc Kolonics et autres

Correction to: Pediatric Research https://doi.org/10.1038/s41390-024-03731-1 , article published online 27 November 2024

hu (code pays fourni par la source)

Long COVID syndrome in children: neutrophilic granulocyte dysfunction and its correlation with disease severity

Fanni Kovács, Tamás Posvai, Eszter Zsáry, Ferenc Kolonics et autres

BACKGROUND: Many children suffer from lingering symptoms after COVID-19, known as long COVID syndrome (LCS), otherwise called Post COVID-19 Condition (PCC). Despite extensive research, the prevalence of symptoms, its impact on quality of life, and underlying mechanisms still need to be fully …

hu (code pays fourni par la source)

Mathematical modeling of transdermal delivery of topical drug formulations in a dynamic microfluidic diffusion chamber in health and disease

Gábor Szederkényi, Dorottya Kocsis, Mihály A. Vághy, Domonkos Czárán et autres

Mathematical models of epidermal and dermal transport are essential for optimization and development of products for percutaneous delivery both for local and systemic indication and for evaluation of dermal exposure to chemicals for assessing their toxicity. These models often help directly by …

hu (code pays fourni par la source)

Lacking ARHGAP25 mitigates the symptoms of autoantibody-induced arthritis in mice

Domonkos Czárán, Péter Sasvári, Ádám Horváth, Krisztina Ella et autres

Objective: Despite intensive research on rheumatoid arthritis, the pathomechanism of the disease is still not fully understood and the treatment has not been completely resolved. Previously we demonstrated that the GTPase-activating protein, ARHGAP25 has a crucial role in the regulation of basic …

hu (code pays fourni par la source)

A novel BRET ‐Based GAP assay reveals phosphorylation‐dependent regulation of the RAC ‐specific GTPase activating protein ARHGAP25

Éva Wisniewski, Domonkos Czárán, Fanni Kovács, Enikő Bahurek et autres

ARHGAP25, a RAC-specific GTPase activating protein (GAP), is an essential regulator of phagocyte effector functions such as phagocytosis, superoxide production, and transendothelial migration. Furthermore, its complex role in tumor behavior has recently been recognized. We previously demonstrated that phosphorylation of serine 363 …

hu (code pays fourni par la source)

Phosphorylation Pattern of ARHGAP25 Determines its Regulatory Effect in Different Conditions.

Aladár Pettkó‐Szandtner, Éva Wisniewski, Domonkos Czárán, Fanni Kovács et autres

ARHGAP25 is highly phosphorylated in its interdomain region.raw files of in vivo and in vitro phosphorylation analyses

Phosphorylation Pattern of ARHGAP25 Determines its Regulatory Effect in Different Conditions.

Aladár Pettkó‐Szandtner, Éva Wisniewski, Domonkos Czárán, Fanni Kovács et autres

ARHGAP25 is highly phosphorylated in its interdomain region.raw files of in vivo and in vitro phosphorylation analyses191213_14.raw recombinant ARHGAP25 tryptic 191213_17.raw recombinant ARHGAP25 phospho enriched 191214_17_WE_2+bioID.raw COS-7 cells191214_14_WE_1+bioID.raw PLB-985 cells

Phosphorylation Pattern of ARHGAP25 Determines its Regulatory Effect in Different Conditions.

Aladár Pettkó‐Szandtner, Éva Wisniewski, Domonkos Czárán, Fanni Kovács et autres

ARHGAP25 is highly phosphorylated in its interdomain region.raw files of in vivo and in vitro phosphorylation analyses191213_14.raw recombinant ARHGAP25 tryptic 191213_17.raw recombinant ARHGAP25 phospho enriched 191214_17_WE_2+bioID.raw COS-7 cells191214_14_WE_1+bioID.raw PLB-985 cells