Hamada S. Abulkhair

Hydrothermal synthesis, photocatalytic hydrogen evolution, CO₂ reduction, organic dyes degradation, heavy metals adsorption, and photoelectrochemical applications of a multifunctional Co- doping NiFe₂O₄ spinel

Maroua Ouezzani, Abdelfattah Allaoui, Hocine Sadam Nesrat, Louiza Zenkhri et autres

Algérie, Tunisie, Égypte (code pays fourni par la source)

Pyridone-based EZH2 inhibitor anticancer candidates: synthetic approaches, comparative analysis, and future perspectives

Hamada S. Abulkhair

Enhancer of Zeste Homolog 2 (EZH2) is a major epigenetic regulator whose dysregulation drives oncogenesis through aberrant trimethylation of H3K27 and silencing tumor-suppressor genes. Pyridone-based small molecules have emerged as the dominant chemotype for targeting the SET domain of EZH2, enabling potent, …

Pyridone-based EZH2 inhibitor anticancer candidates: synthetic approaches, comparative analysis, and future perspectives

Hamada S. Abulkhair

Enhancer of Zeste Homolog 2 (EZH2) is a major epigenetic regulator whose dysregulation drives oncogenesis through aberrant trimethylation of H3K27 and silencing tumor-suppressor genes. Pyridone-based small molecules have emerged as the dominant chemotype for targeting the SET domain of EZH2, enabling potent, …

Pyridone-based EZH2 inhibitor anticancer candidates: synthetic approaches, comparative analysis, and future perspectives

Hamada S. Abulkhair

Enhancer of Zeste Homolog 2 (EZH2) is a major epigenetic regulator whose dysregulation drives oncogenesis through aberrant trimethylation of H3K27 and silencing tumor-suppressor genes. Pyridone-based small molecules have emerged as the dominant chemotype for targeting the SET domain of EZH2, enabling potent, …

id, Égypte (code pays fourni par la source)

Author response for "Rational design and synthesis of Co(II), Ni(II) and Cu(II) complexes bearing 1,2,4-triazole scaffold for biological applications"

Azza A. Hassoon, Hamada S. Abulkhair, Ranim H. Ashour, Mariam M. Abdelsamea et autres

Therapeutic Horizons in Targeting EZH2 With Dual and Non‐PROTAC Inhibitor Molecules: Recent Achievements, Comparative Analysis, and Future Perspectives

Hamada S. Abulkhair

The aberrant overexpression of Enhancer of Zeste Homolog 2 (EZH2) endorses uncontrolled cell proliferation and metastasis across multiple malignancies. These make EZH2 an attractive biological target for the development of potential anticancer molecules. Following the approval of Tazemetostat, the last 5 years …

Égypte (code pays fourni par la source)

Author response for "Rational design and synthesis of Co(II), Ni(II) and Cu(II) complexes bearing 1,2,4-triazole scaffold for biological applications"

Azza A. Hassoon, Hamada S. Abulkhair, Ranim H. Ashour, Mariam M. Abdelsamea et autres

Therapeutic horizons in the development of PROTAC-based EZH2 inhibitors: recent achievements, comparative analysis, and future perspectives

Hamada S. Abulkhair

= 34 nM in EOL-1 cells) with concentration- and time-dependent activity, establishing a benchmark for efficient EZH2 elimination. Compounds P3 (72) and P4 (73) (VHL-based) and U3i (44) (CRBN-based) also demonstrated potent dual biochemical and cellular profiles. Recent findings emphasize structure-activity trends, …

Égypte (code pays fourni par la source)

Rational design and synthesis of Co( ii ), Ni( ii ) and Cu( ii ) complexes bearing 1,2,4-triazole scaffold for biological applications

Azza A. Hassoon, Hamada S. Abulkhair, Ranim H. Ashour, Mariam M. Abdelsamea et autres

The synthesis of 4-amino-3-hydrazino-5-mercapto-1,2,4-triazole (AHMT) metal complexes, followed by comprehensive physico-chemical characterization, evaluation of their biological applications and molecular docking studies.

Égypte (code pays fourni par la source)

Therapeutic horizons in targeting XPO1 with small inhibitor molecules: Recent achievements, synthetic strategies, opportunities, challenges, and future perspectives

Hamada S. Abulkhair

Égypte (code pays fourni par la source)

α-Glucosidase-targeting 1,2,4-triazole antidiabetic candidates: comparative analysis and future perspectives

Hamada S. Abulkhair

Diabetes mellitus develops because of the disturbance in carbohydrate metabolism. The therapeutic goal for antidiabetic medications is to manage blood glucose level and to prevent hyperglycemia-associated complications. α-Glucosidase inhibitors represent one of the widely used oral hypoglycemics. This review highlights the potential …

Égypte, id (code pays fourni par la source)

A bottomless well: 1,2,4-Triazoles continue to inspire scientific researchers to develop more and more anticancer molecules

Hamada S. Abulkhair

Égypte (code pays fourni par la source)