Accès ouvert
2026
preprint
OpenAlex
Francesco Montagner, Myriam Scherer, Cora Stegmann, Friedrich Hahn et autres
Abstract Recent studies demonstrated that the structural maintenance of chromosomes complex 5/6 (SMC5/6) acts as an important antiviral restriction factor that silences episomal DNA. Consequently, viruses have evolved strategies to antagonize this defence system. Interestingly, it was shown that SMC5/6-mediated silencing of …
jp, de
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2026
article
OpenAlex
Conrad Weidt, Adela Maria Neagoie, Maral Saadati, Daniel Fürst et autres
Introduction: Letermovir (LET) is an effective prophylaxis for human cytomegalovirus (HCMV) reactivations in HCMV-seropositive patients after allogeneic stem cell transplantation (allo-SCT). HCMV promotes polyfunctional T-cell responses, leading to HCMV-specific immune reconstitution (IR), thus contributing to polyclonal IR. Methods: We retrospectively analyzed HCMV-seropositive …
de
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Accès ouvert
2026
preprint
OpenAlex
Dennis Freisem, Daniel Rombach, Sarah J. Brockmann, Anne Fink et autres
ABSTRACT Transactive response DNA binding protein 43 kDa (TDP-43) pathology, is a central molecular hallmark of amyotrophic lateral sclerosis (ALS). However, the underlying triggers are incompletely understood. Here, we show that infection with herpes simplex virus (HSV) induces molecular hallmarks of ALS …
de, us, nl, at
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Accès ouvert
2025
article
OpenAlex
Nicoleta Trif, Christopher Kloth, Susanne Martina Büttner, N Egenrieder et autres
Background: Software-guided semi-quantitative analysis of coronavirus disease 2019 (COVID-19) pneumonia in lung computed tomography (CT) datasets for severity assessment. Further to correlate imaging findings with the need of intensive care medicine and clinical parameters. Methods: This single-center retrospective study analyzed 66 consecutive …
de
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Accès ouvert
2025
article
OpenAlex
Julia Mai, Thomas Stamminger, Sabrina Schreiner
Daxx and HIRA are key proteins in the host response to DNA virus infections. Daxx is involved in apoptosis, transcription regulation, and stress responses. During DNA virus infections, Daxx helps modulate the immune response and viral progression. Viruses like adenoviruses and herpesviruses …
de
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Accès ouvert
2025
preprint
OpenAlex
Š. Bauer, Sarah Tarhini, Emmanuelle Buhler, Thomas Stamminger et autres
Abstract Background Congenital cytomegalovirus (CMV) infections are one leading cause of human neurodevelopmental disorders. Increasing evidence for the pathogenic involvement of brain immune alterations was obtained in the recent years. Host and virus-encoded chemokines might play important roles in CMV-related neuropathogenesis by …
fr, us, de
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2025
preprint
OpenAlex
Julia Mai, Maryam Karimi, Anna Katharina Kuderna, Thomas Guenther et autres
Abstract The DNA double-stranded genome of human adenoviruses (HAdV) is preferentially targeted by host factors involved in chromatin remodeling, such as SPOC1 and KAP1 to inhibit efficient viral gene expression. HAdV genomes undergo alterations through association with host histones and epigenetic modifications; …
de
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Accès ouvert
2025
preprint
OpenAlex
Matthias Hehl, Myriam Scherer, Eva-Maria Raubuch, Claudia Ploil et autres
Abstract ISG20 is an interferon-regulated protein that exhibits RNase activity thereby inhibiting the replication of a broad spectrum of RNA viruses. By single cell RNA sequencing, we identified ISG20 as an antiviral factor for human cytomegalovirus (HCMV) as it was upregulated in …
de, pt
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Accès ouvert
2024
article
OpenAlex
Sarah Tarhini, Carla Crespo-Quiles, Emmanuelle Buhler, Louison Pineau et autres
BACKGROUND: Congenital cytomegalovirus (CMV) infections represent one leading cause of human neurodevelopmental disorders. Despite their high prevalence and severity, no satisfactory therapy is available and pathophysiology remains elusive. The pathogenic involvement of immune processes occurring in infected developing brains has been increasingly …
fr, es, de
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Accès ouvert
2024
conference-abstract
OpenAlex
Adela Maria Neagoie, Conrad Weidt, Daniel E. Furst, Verena Wais et autres
Introduction. Letermovir (LTV) showed to reduce the incidence of Cytomegalovirus (CMV) reactivations in CMV-seropositive patients after allogeneic stem cell transplantation (allo-SCT). CMV reactivations are known to stimulate polyfunctional T-cell responses, which foster the development of CMV-specific immune reconstitution (IR) and contribute to …
de
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Accès ouvert
2024
preprint
OpenAlex
Jiang Tan, Vedran Franke, Eva Neugebauer, Justine Lagisquet et autres
Transposable elements (TEs) are implicated in a variety of processes including placental and preimplantation development and a variety of human diseases. TEs are known to be activated in the context of some viral infections, but the mechanisms and consequences are not understood. …
de
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Accès ouvert
2024
article
OpenAlex
Anna K. Kuderna, Anna Reichel, Julia Tillmanns, Maja Class et autres
The chromatin-remodeler SPOC1 (PHF13) is a transcriptional co-regulator and has been identified as a restriction factor against various viruses, including human cytomegalovirus (HCMV). For HCMV, SPOC1 was shown to block the onset of immediate-early (IE) gene expression under low multiplicities of infection …
pt, de
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